Possibilities and Limitations of High-Dose Barbiturate Therapy in the Management of Intracranial Hypertension

  • H. Collmann
  • J. W. Gethmann
  • E. Kazner
  • C. Sprung
Conference paper
Part of the Advances in Neurosurgery book series (NEURO, volume 14)


Reduction of increased intracranial pressure is a well documented effect of barbiturates (1–4 7, 8 11, 13–15) whereas their protective effect in cerebral ischemia remains doubtful (16). But even the reliability of the drug effect on intracranial hypertension has yet to be determined, and in a first study on 34 patients (3) we found that barbiturates are less effective than previously reported (7, 8). The aim of the present study was to reconsider that conclusion on the basis of a larger population of treated patients.


Intracranial Pressure Intracranial Hypertension Severe Head Injury Barbiturate Coma Epidural Pressure 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • H. Collmann
    • 1
  • J. W. Gethmann
    • 1
  • E. Kazner
    • 1
  • C. Sprung
    • 1
  1. 1.Neurochirurgische Abteilung, Klinikum CharlottenburgFreie Universität BerlinBerlin 19Germany

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