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Possibilities and Limitations of High-Dose Barbiturate Therapy in the Management of Intracranial Hypertension

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Spinal Cord Tumors Experimental Neurosurgery Neurosurgical Intensive Care

Part of the book series: Advances in Neurosurgery ((NEURO,volume 14))

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Abstract

Reduction of increased intracranial pressure is a well documented effect of barbiturates (1–4 7, 8 11, 13–15) whereas their protective effect in cerebral ischemia remains doubtful (16). But even the reliability of the drug effect on intracranial hypertension has yet to be determined, and in a first study on 34 patients (3) we found that barbiturates are less effective than previously reported (7, 8). The aim of the present study was to reconsider that conclusion on the basis of a larger population of treated patients.

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References

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Author information

Authors and Affiliations

  1. Neurochirurgische Abteilung, Klinikum Charlottenburg, Freie Universität Berlin, Spandauer Damm 130, D-1000, Berlin 19, Germany

    H. Collmann, J. W. Gethmann, E. Kazner & C. Sprung

Authors
  1. H. Collmann
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  2. J. W. Gethmann
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  3. E. Kazner
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  4. C. Sprung
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Editor information

Editors and Affiliations

  1. Neurochirurgische Abteilung im Krankenhaus Neukölln, Rudower Str. 56, D-1000, Berlin 47, Germany

    Horst Wenker  & Friedrich Reuter  & 

  2. Neurochirurgische Klinik der Universität Erlangen-Nürnberg, Schwabachanlage 6 (Kopfklinikum), D-8520, Erlangen, Germany

    Margareta Klinger

  3. Neurochirurgische Klinik und Poliklinik, Universitätsklinikum Steglitz, Freie Universität Berlin, Hindenburgdamm 30, D-1000, Berlin 45, Germany

    Mario Brock

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© 1986 Springer-Verlag Berlin Heidelberg

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Collmann, H., Gethmann, J.W., Kazner, E., Sprung, C. (1986). Possibilities and Limitations of High-Dose Barbiturate Therapy in the Management of Intracranial Hypertension. In: Wenker, H., Klinger, M., Brock, M., Reuter, F. (eds) Spinal Cord Tumors Experimental Neurosurgery Neurosurgical Intensive Care. Advances in Neurosurgery, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71108-4_51

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  • DOI: https://doi.org/10.1007/978-3-642-71108-4_51

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-16360-2

  • Online ISBN: 978-3-642-71108-4

  • eBook Packages: Springer Book Archive

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