Abstract
Since BEHAR (1) first introduced epidural morphine for treatment of pain, morphine solution has generally been administered in a high injection volume. Yet epidural morphine in low injection volumes is also effective in the treatment of acute (3, 2) and chronic (4, 8) pain, as we were able to prove in 1984 (6). Recently we have demonstrated that cisternal cerebellomedullary CSF concentrations of morphine are dependent on the volume of the epidural injection; this suggests that the risk of respiratory depression might be reduced with low-volume injections of epidural morphine (5), as HUG et al. demonstrated in 1981 that there is an evident relationship between cisternal cerebellomedullary CSF concentrations and end-tidal CO2 (10).
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References
Behar, M., Magora, F., Olshwang, D., Davidson, J.T.: Epidural morphine in treatment of pain. Lancet I, 527–529 (1979)
Bromage, P.R., Camporesi, E., Chestnut, D.: Epidural narcotics for postoperative analgesia. Anesth. Analg. 59 473–480 (1980)
Chrubasik, J.: Epidural, on demand, low-dose morphine infusion for postoperative pain. Lancet II, 107–108 (1984)
Chrubasik, J.: Low-dose morphine by infusion pump. Lancet I, 738–739 (1984)
Chrubasik, J., Scholler, K.L., Wiemers, K., Weigel, K., Friedrich, G.: Low-dose infusion of morphine prevents respiratory depression. Lancet I, 793 (1984)
Chrubasik, J., Wiemers, K.: Kein analgetischer Wirkungsverlust durch peridurale “Low-Volume”-Morphingabe. Anaesthesist 33 451 (1984)
Chrubasik, J., Wiemers, K.: Continuous-plus-on-demand epidural infusion of morphine for postoperative pain relief by means of a small, externally worn infusion device. Anesthesiology 62, 263–266 (1985)
Coombs, D.W., Saunders, R.L., Gaylor, M., Pageau, M.G.: Epidural narcotic infusion reservoir: implantation technique and efficacy. Anesthesiology 56, 469–473 (1982)
Gustafsson, L.L., Schildt, B., Jacobsen, K.: Adverse effects of extradural and intrathecal opiates: report of a nationwide survey in Sweden. Br. J. Anaesth. 54, 479–486 (1982)
Hug, C.C., Murphy, M.R., Rigel, E.P., Olson, W.A.: Pharmacokinetics of morphine injected intravenously into the anesthetized dog. Anesthesiology 54, 38–47 (1981)
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© 1986 Springer-Verlag Berlin Heidelberg
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Weigel, K., Chrubasik, J., Friedrich, G., Mundinger, F. (1986). Rostral Spread of Epidural 3H-Labeled Morphine. In: Wenker, H., Klinger, M., Brock, M., Reuter, F. (eds) Spinal Cord Tumors Experimental Neurosurgery Neurosurgical Intensive Care. Advances in Neurosurgery, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71108-4_42
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DOI: https://doi.org/10.1007/978-3-642-71108-4_42
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