Intracarotid Amobarbital Testing and Assessment of Speech Laterality

  • H. Silfvenius
Conference paper

Abstract

Intracarotid injection of sodium amobarbital (Amytal) transiently blocks the perfused cerebral hemi-sphere. It allows for investigations of various intra- and interhemispheric functions which must be clarified in the individual patient and which are of importance for the understanding of brain function in neurological disease. The bilateral intracarotid amobarbital test which Wada and Rasmussen (1960) used preoperatively on patients with intractable epilepsy has given otherwise unobtainable information on lateralization of speech and memory functions (Milner et al. 1962,1964). The test may be used when there is uncertainty about speech lateralization and memory function, side of epileptic lesion, EEG, or neuropsychological findings.

Keywords

Neurol Barbiturate Aphasia Barbital Clari 

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References

  1. Aasly I, Silfvenius H (1985) Methodological considerations on an extended intracarotid Amytal test for epileptic patients (unpublished)Google Scholar
  2. Aasly I, Silfvenius H (1985) Stereognostic memory of cerebral hemispheres studied in epileptic patients during bilateral intracarotid Amytal testing. 13th World Congr Neurol, HamburgGoogle Scholar
  3. Ajersch MK, Milner B (1983) Handwriting posture as related to cerebral speech lateralization, sex, and writing hand. Human Neurobiol 2: 143–145Google Scholar
  4. Blume WT, Grabow JD, Darley FL, Aronson AF (1973) Intracarotid amobarbital test of language and memory before temporal lobectomy for seizure control. Neurology 23: 812–819PubMedGoogle Scholar
  5. Christianson S-A, Silfvenius H, Nilsson L-G (1987) Hemisphere memory of concrete and abstract information determined with the intracarotid Sodium Amytal test Epilepsy Res 1: 185–193Google Scholar
  6. Engel J Jr, Rausch R, Lieb JP, Kuhl DE, Crandall PH (1981) Correlation of criteria used for localizing epileptic foci in patients considered for surgical therapy of epilepsy. Ann Neurol 9: 215–224PubMedCrossRefGoogle Scholar
  7. Fedio B, Weinberg LK (1971) Dysnomia and impairment of verbal memory following intracarotid injection of sodium amytal. Brain Res 31: 159–168PubMedCrossRefGoogle Scholar
  8. Klove H, Grabow JD, Trites RL (1969) Evaluation of memory functions with intracarotid sodium amytal. Trans Am Neurol Assoc 94: 76–80PubMedGoogle Scholar
  9. McGlone J (1984) Speech comprehension after unilateral in-jection of sodium Amytal. Brain Lang 22: 150–157PubMedCrossRefGoogle Scholar
  10. McGlone J, Fox AJ (1982) Evidence from sodium amytal studies of greater asymmetry of verbal representation in men compared to women. In: AkimotoH, KazamatsuriH, SeinoM, Ward A (eds) Advances in epileptology. 13th epilepsy international symposium. Raven, New York, pp 389–391Google Scholar
  11. Milner B (1975) Psychological aspects of focal epilepsy and its surgical management. In: Purpura DP, PenryJK, Walter RD (eds) Advances in neurology, vol 8. Raven, New York, pp 299–319Google Scholar
  12. Milner B (1976) Hemispheric asymmetry in the control of gesture sequences. In: KimuraD (ed) Symposium on asymmetric processing in the cerebral hemispheres. Proceedings of the 21st international congress of psychology, Paris, p 149Google Scholar
  13. Milner B, Branch, Rasmussen T (1962) Study of short-term memory after intracarotid injection of sodium amytal. Trans Am Neurol Assoc 87: 224–226Google Scholar
  14. Milner B, Branch C, Rasmussen T (1964) Observations on cerebral dominance. In: de ReuckAVS, O’ConnorM (eds) Ciba foundation symposium on disorders of language. Churchill, London, pp 200–214Google Scholar
  15. Milner B, Branch C, Rasmussen T (1966) Evidence for bilateral speech representation in some non-right-handers. Trans Am Neurol Assoc 91: 306–308Google Scholar
  16. Oxbury SM, Oxbury JM (1984) Intracarotid Amytal test in the assessment of language dominance. In: RoseFC (ed) Advances in neurology. Prog Aphasiol 42: 115–123Google Scholar
  17. Ratcliff G, Dila D, Taylor L, Milner B (1981) The morphological asymmetry of the hemispheres and cerebral dominance for speech: a possible relationship. Brain Lang 11: 87–98CrossRefGoogle Scholar
  18. Rausch R, Walsh GO (1984) Right-hemisphere language dominance in righthanded epileptic patients. Arch Neurol 41: 1077–1080PubMedGoogle Scholar
  19. Rausch R, Fedio P, Ary CM, Engel J, Crandall PH (1984) Resumption of behavior following intracarotid sodium amo-barbital injection. Ann Neurol 15: 31–35PubMedCrossRefGoogle Scholar
  20. Risse GL, Gazzaniga MS (1978) Well-kept secrets of the right hemisphere: a carotid amytal study of restricted memory transfer. Neurology 28: 950–953PubMedGoogle Scholar
  21. Serafetinides EA (1966) Auditory recall and visual recognition following intracarotid sodium amytal injections. Cortex 2: 367–372Google Scholar
  22. Silfvenius H, Blom S, Nilsson L-G, Christianson S-A (1984) Observations on verbal, pictorial and stereognostic memory in epileptic patients during intracarotid amytal testing. Acta Neurol Scand [Suppl] 99: 57–77CrossRefGoogle Scholar
  23. Volpe BT, Sidtis JJ, Gazzaniga MS (1981) Can left-handed writing posture predict cerebral language laterality? Arch Neurol 38: 637–638PubMedGoogle Scholar
  24. Wada J, Rasmussen T (1960) Intracarotid injection of sodium amytal for the lateralization of cerebral speech dominance. Experimental and clinical observations. J Neurosurgl7: 266–282Google Scholar
  25. Willmore LJ, Wilder BJ, Mayersdorf A, Ramsay RE, Sypert GW (1978) Identification of speech lateralization by intracarotid injection of methohexital. Ann Neurol 4: 86–88PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • H. Silfvenius
    • 1
  1. 1.Department of NeurosurgeryUniversity HospitalUmeåSweden

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