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Chairman’s Commentary

  • P. Kleihues
Conference paper

Abstract

The session on morphological sequelae of chronic epilepsy was initiated by C. J. Bruton with an over-view covering both historical and present views on the pathogenesis of epileptic brain damage. His own experience is based mainly on the unique collection of biopsies from 249 temporal lobectomy patients, who had been operated upon by the late Dr. Falconer. It was pointed out in the discussion that this series, although extremely valuable for pathologists, was collected before 1975, when CT, PET, and NMR were not yet available. Correlation with clinical data is, therefore, limited. This is, in part, also true for the morphological analyses. Modern techniques including immunohistochemistry and transmitter and receptor autoradiography were not performed, but Dr. Bruton announced that some immunohistochemical studies that can be carried out on paraffin-embedded material will be conducted in the near future.

Keywords

Epileptic Seizure Present View Chronic Epilepsy Receptor Autoradiography Unique Collection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Benardo LS, Pedley TA (1985) Cellular mechanisms of focal epileptogenesis. In: Pedley TA, Meldrum BS (eds) Recent advances in epilepsy, vol 2. Churchill Livingstone, Edinburgh, pp 1–18Google Scholar
  2. Chapman AG (1985) Cerebral energy metabolism and seizures. In: Pedley TA, Meldrum BS (eds) Recent advances in epilepsy, vol 2. Churchill Livingstone, Edinburgh, pp 19–64Google Scholar
  3. Kiessling M, Xie Y, Kleihues P (1984) Regional impairment of protein synthesis in the rat brain during bicuculline-induced seizures. Brain Res 296: 1–13PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • P. Kleihues

There are no affiliations available

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