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Particular Problems of Histological Preparation and Assessment: Advanced Methods

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Book cover Tumours of the Larynx

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Abstract

The histological preparation of whole larynges in the form of multiple serial sections is made considerably more difficult by the difference in hardness of the various tissue types in this organ, and in particular by the age-dependent ossification of cartilaginous parts of the skeleton. The detailed knowledge regarding the spread of endolaryngeal tumours that is of invaluable worth for diagnosis and therapy can be most readily gained from whole-organ sections, in which the behaviour of the tumours in relation to the different anatomical structures in the larynx is evident and more exactly discernible.

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References

  • ABRAMSON M, HUANG Cc, SCHILLING RW, SALOME RG (1975): Collagenase activity in epidermoid carcinoma of the oral cavity and larynx. Ann Otol Rhinol Laryngol 84: 158–163

    PubMed  CAS  Google Scholar 

  • AMTHOR M, TOMASKOWITZ H (1970): Ein Verfahren zur Herstellung histologischer Organschnitte. Z wiss Mikr 70: 130–134

    PubMed  CAS  Google Scholar 

  • ANDREASSON L, BJÖRLIN G, KORSGAARD R, MATTIASSON I, TRELL E, TRELL L (1982): Leucoplakia of the oral cavity and the arylhydrocarbon-hydrolase inducibility. Postgrad Med J 58:138–141

    PubMed  CAS  Google Scholar 

  • BANCROFT JD, STEVENS A (1977): Theory and practice of histological techniques. Churchill Livingston, Edinburgh- London-New York

    Google Scholar 

  • BANOCZY J (1982): Oral leukoplakia. Budapest: Akadémiai Kiadó

    Google Scholar 

  • BICHLER E, MIKUZ G, ZINGERLE N (1985): A comment on laryngeal cytology. Arch Otorhinolaryngol 241: 209–211

    PubMed  CAS  Google Scholar 

  • BIER J, NICKLISCH U, PLATZ H (1983): The doubtful relevance of nonspecific immune reactivity in patients with squamous cell carcinoma of the head and neck. Cancer 52: 1165–1172

    PubMed  CAS  Google Scholar 

  • Bjelkenkrantz K, Olofsson J, Stal O, GrÖNtoft O (1983): Juvenile laryngeal papilloma: histologic and photometric evaluation of atypia. Laryngoscope 83: 468–474

    Google Scholar 

  • BOS I, BURKHARDT A (1981): Epithelial and interepithelial mitoses of the oral mucosa. Light and electron microscopic study in mice after exposure to different antigens. J Invest Dermatol 76: 63–67

    PubMed  CAS  Google Scholar 

  • BRAIN EB (1966): The preparation of decalcified sections Charles C Thomas, Springfield Ill, USA

    Google Scholar 

  • BRODERS AC (1920): Squamous-cell epithelioma of the lip. JAMA 74: 656–664

    Google Scholar 

  • BRODERS AC (1921): Squamous-cell epithelioma of skin: A study of 256 cases. Ann Surg 73:141–160

    PubMed  CAS  Google Scholar 

  • BRODERS AC (1922): Epithelioma of the genitourinary organs. Ann Surg 75: 574–604

    PubMed  CAS  Google Scholar 

  • BURKHARDT A (1980): Der Mundhöhlenkrebs und seine Vorstadien. Ultrastrukturelle und immunpathologische Aspekte. Fischer, Stuttgart-New York

    Google Scholar 

  • Burkhardt A (1984): Advanced methods in the evaluation of premalignant lesions and carcinomas of the oral mucosa. J Oral Pathol 14: 751–778

    Google Scholar 

  • BURKHARDT A (1985): Prämaligne Veränderungen der Mundschleimhaut. Vorschläge einer internationalen Expertenkommission zur Nomenklatur. Pathologe 6:126–132

    PubMed  CAS  Google Scholar 

  • Burkhardt A, Maerker R (1981): A colour atlas of oral cancers. The diagnosis of leukoplakias, precancerous conditions and carcinomas. Wolfe Medical Publications Ltd, London; Year Book Medical Publishers Inc., Chicago

    Google Scholar 

  • CALDERON-SOLT L, SOLT Db (1985): Gamma-glutamyl transpeptidase in precancerous lesions and carcinomas of oral, pharyngeal, and laryngeal mucosa. Cancer 56:138–143

    PubMed  CAS  Google Scholar 

  • CHODAK GW, HAUDENSCHILD C, GITTES RF, FOLKMAN J (1980): Angiogenic activity as a marker of neoplastic and preneoplastic lesions of the human bladder. Ann Surg 192: 762–771

    PubMed  CAS  Google Scholar 

  • CHRETIEN PB (1975): Unique immunobiological aspects of head and neck squamous carcinoma. Can J Otolaryngol 4: 225–235

    PubMed  CAS  Google Scholar 

  • CHRETIEN PB (1978): The effects of smoking on immune-competence. Laryngoscope 88 (Suppl 8): 11–13

    PubMed  CAS  Google Scholar 

  • CINBERG JZ, CHANG TH, BASES R, MOLNAR J (1980): The percentage of cells in DNA synthesis in epidermoid carcinomas of the head and neck: a preliminary report. Laryngoscope 90: 920–923

    PubMed  CAS  Google Scholar 

  • CINBERG JC, CHANG TH, HEBBARD P, BASES R, VOGL SE (1983): An application of immunocytology to the analysis of the cell kinetics of upper respiratory and digestive tract squamous carcinoma. Cancer 51:1843–1846

    PubMed  CAS  Google Scholar 

  • CLAYDEN EC (1952): A discussion on the preparation of bone sections by the paraffin wax method with special reference to the control of decalcification. J Med Lab Technol 10: 103–123

    Google Scholar 

  • CORTESINA G, SARTORIS A, DI FORTUNATO V, CAVALLO GP, MORRA B, BUSSI M, BEATRICE F, POGGIO E, MARCATO P, RENDINE S (1984): Natural killer-mediated cytotoxicity in patients with laryngeal carcinoma. Ann Otol Rhinol Laryngol 93:189–191

    PubMed  CAS  Google Scholar 

  • CRISSMAN JD, FU YS (1986): A clinicopathologic study of six cases with DNA analysis. Arch Otolaryngol 112: 522–528

    CAS  Google Scholar 

  • DANIELSON JR, FRANKLIN WA (1984): Characterization of antibody-forming cells adjacent to laryngeal carcinoma. Arch Otolaryngol 110: 327–328

    PubMed  CAS  Google Scholar 

  • DAWSON DE, EVERTS ECE, VETTO RM, BURGER DR (1985): Assessment of immunocompetent cells in patients with head and neck squamous cell carcinoma. Ann Otol Rhinol Laryngol 94: 342–345

    PubMed  CAS  Google Scholar 

  • DENARO A, CARUSO R, ROSSI M, D’ARRIGO C, MALAPONTE G, MAZZARINO MC, CUTRONA D (1985): Circulating immunocomplexes and laryngeal carcinoma. Arch Otolaryngol 111: 595–597

    PubMed  CAS  Google Scholar 

  • ELÖ J (1983): Die Bedeutung des Malignitätsgrades und der Proliferationsaktivitat des Larynxkarzinoms für regionäre Lymphknotenmetastasen. Laryngol Rhinol Otol 62: 244–245

    Google Scholar 

  • EVANS AW, JOHNSON NW, BUTCHER RG (1983): A quantitative histochemical study of glucose-6-phosphate dehydrogenase activity in premalignant and malignant lesions of human oral mucosa. Histochem J 15: 483–489

    PubMed  CAS  Google Scholar 

  • EVESON JW (1981): Animal models of intra-oral chemical carcinogenesis: a review. J Oral Pathol 10:129–146

    PubMed  CAS  Google Scholar 

  • FELIX H, TCHAO R, SCHLEICH A, HOFFMANN V (1982): Interactions of tumor cells with human amnion membrane: a model for studying tumor invasion in vitro. Scan Electron Microsc 2: 741–749

    Google Scholar 

  • FLETCHER GH, OLD JW, LOQUVAM GS (1954): A topographic approach to the roentgenologic and pathologic examination of the laryngopharyngeal tumours. Radiology 63: 361–380

    PubMed  CAS  Google Scholar 

  • FRABLE WJ, FRABLE MA (1968): Cytologic diagnosis of carcinoma of the larynx by direct smear. Acta Cytol (Baltimore) 12:318–324

    CAS  Google Scholar 

  • FRANKLIN CD, GOHARI K, SMITH CJ, WHITE FH (1980): Quantitative evaluation of normal hyperplastic, and premalignant epithelium by stereological methods. In: MACKENZIE JC, DABELSTEEN E, SQUIER CA (eds), Oral premalignancy; pp 243–261. University of Iowa Press

    Google Scholar 

  • FRANZ B, NEUMANN OG (1978): Leukoplakien des Kehlkopfes. Histologisch-zytologische Klassifizierung. Laryngol Rhinol Otol 57: 428–433

    CAS  Google Scholar 

  • FRÜHWALD H (1979): Zum Wert der Larynxzytologie als Screening-Untersuchung. Laryngol Rhinol Otol 58: 698–699

    Google Scholar 

  • GARDNER AF (1965): The use of acid phosphatase localization as a differential staining technique for keratin. Oral Surg 20: 218–225

    PubMed  CAS  Google Scholar 

  • GIARELLI L, SILVESTRI F, ANTONUTTO G, STANTA G (1977): Observation of the pathologist on precancerous lesions of the larynx. Integrated with histological data and quantitative analysis of nuclear DNA-content. Acta Otolaryngol (Suppl)(Stockh) 344: 7–18

    CAS  Google Scholar 

  • GIEREK T, LISIEWICZ J, MOSZCZY’NSKI P, PILCH J, NAMYSLOWSKI G (1985): Enzymatic deficiencies of the immune system cells in patients with cancer of the larynx and other malignancies. Auris Nasus Larynx (Tokyo) 12: 47–51

    CAS  Google Scholar 

  • GLANZ HK (1984): Carcinoma of the larynx; growth, p-classification and grading of squamous cell carcinoma of the vocal cords. Adv Otorhinolaryngol 32:1–123

    PubMed  CAS  Google Scholar 

  • GOLABEK W, SZYSZKO J (1984): Lactate dehydrogenase activity in laryngeal carcinoma and surrounding mucosa. Clin Otolaryngol 9:9–13

    PubMed  CAS  Google Scholar 

  • GRÖNTOFT O, HELLQUIST A, OLOFSSON J, NORDSTRÖM L (1978): The DNA content and nuclear size in normal, dysplastic and carcinomatous laryngeal epithelium. Acta Otolaryngol (Stockh) 86: 473–479

    Google Scholar 

  • GRUNDMANN E (1973): Die Bedeutung der präkanzerösen Zell- und Gewebsveränderungen in Experiment und Klinik. Arch Otorhinolaryngol 205: 55–67

    CAS  Google Scholar 

  • HAMBURGER AW, SALMON SE (1977): Primary bioassay of human tumor stem cells. Science 197: 461–463

    PubMed  CAS  Google Scholar 

  • HANSEMANN D (1890): Über asymmetrische Zellteilung in Epithelkrebsen und deren biologische Bedeutung. Virchows Arch path Anat 119: 299–326

    Google Scholar 

  • HANSON J, BRUCHMÜLLER W (1983): Rasterelektronenmikroskopische Schleimhautstudien an Larynx-Präkanzerosen. HNO 31: 359–365

    PubMed  CAS  Google Scholar 

  • HARABUCHI Y, YAMANAKA N, KATAURA A (1985): Identification of lymphocyte subsets and natural killer cells in head and neck cancers. An immunohistological study using monoclonal antibodies. Arch Otorhinolaryngol 242: 89–97

    PubMed  CAS  Google Scholar 

  • HARRISON DFN (1979): Intrinsic weakness of the TNM system for classification of laryngeal cancer. ORL 41: 241–251

    PubMed  CAS  Google Scholar 

  • HELLQUIST H, OLOFSSON J (1981): Photometric evaluation of laryngeal epithelium exhibiting hyperplasia, keratosis and moderate dysplasia. Acta Otolaryngol (Stockh) 92: 157–165

    CAS  Google Scholar 

  • HERRMANN JF, SCHAUER A, FINSTERER H (1973): Zur Erkennung praeneoplastischer Veränderungen am Larynx. (Recognizing premalignant changes in the larynx). Laryngol Rhinol Otol 52: 655–660

    CAS  Google Scholar 

  • HEYDEN G (1974): Histochemical investigation of malignant cells. Histochemistry 39: 327–334

    PubMed  CAS  Google Scholar 

  • HEYDEN G, ARWILL T, HÖGBERG M (1974): A new routine in histopathology. Br J Dermatol 90: 579–582

    PubMed  CAS  Google Scholar 

  • HILL MW (1980): Cell kinetics in premalignancy. In: MACKENZIE IC, DABELSTEEN E, SQIER CA (eds), Oral premalignancy; pp 191–212. University of Iowa Press

    Google Scholar 

  • HOLM LE, JAKOBSSON P, KILLANDER D, SILFVERSWÄRD C, WERSÄLL J (1980): DNA and its synthesis in indivdual tumor cells from human upper respiratory tract squamous cell carcinomas. Laryngoscope 90:1209–1212

    PubMed  CAS  Google Scholar 

  • HOLM LE (1982): Cellular DNA amounts of squamous cell carcinomas of the head and neck region in relation to prognosis. Laryngoscope 92:1064–1069

    PubMed  CAS  Google Scholar 

  • HOLMSTRUP P, DABELSTEEN E, ROED-PETERSEN B (1981): Oral leukoplakia transplanted to nude mice. Scand J Dent Res 89:275–282

    PubMed  CAS  Google Scholar 

  • HOMMERICH KW, SAUER H, WEEDE W (1971): Zur Wachstumstendenz von Larynxtumoren. Arch Otorhinolaryngol 199:748–751

    CAS  Google Scholar 

  • HOMMERICH KW (1974): Röntgenbefunde und mikroskopisches Wachstum von malignen Larynxtumoren. Laryng Rhinol Otol 53: 845–855

    CAS  Google Scholar 

  • HUME WJ, POTTEN CS (1979): Advances in epithelial kinetics: an oral view. J Oral Pathol 8: 3–22

    PubMed  CAS  Google Scholar 

  • HUME WJ (1981): A theoretical consideration of some biological parameters involved in cell kinetic investigations of oral leukoplakia and abnormal stratified squamous epithelium. J Oral Pathol 10: 375–385

    PubMed  CAS  Google Scholar 

  • JAKOBSSON PA, ENEROTH CM, KILLANDER D et al. (1973): Histological classification and grading of malignancy in cancer of the larynx. Acta Radiol Oncol 12:1–8

    CAS  Google Scholar 

  • JOHNS ME, MILLS SE (1983): Cloning efficiency. A possible prognostic indicator in squamous cell carcinoma of the head and neck. Cancer 52:1401–1404

    PubMed  CAS  Google Scholar 

  • JOHNSON NW, EVANS AW, MORGAN PR, BUTCHER RG (1980): Biochemical and histochemical changes in oral premalignancy. In: MACKENZIE IC, DABELSTEEN E, SQUIER CA (eds), Oral premalignancy; pp 312–334.University of Iowa Press

    Google Scholar 

  • KASHIMA HK (1976): The characteristics of laryngeal cancer correlating with cervical lymph node metastasis. In: ALBERTI PW, BRYCE DP (eds), Centennial Conference on Langeal Cancer; pp 855–864. Appleton-Century-Crofts, New York

    Google Scholar 

  • KERNAN JD (1950): The pathology of carcinoma of the larynx studied in serial sections. Trans Am Acad Ophth Otol 55:10–21

    CAS  Google Scholar 

  • KLEINSASSER O (1967): Wachstumsformen der Kehlkopfein-gangscarcinome und Indikation zur Teilresektion. Wiss Z Karl-Marx-Univ (Lpz) 16: 723–725

    Google Scholar 

  • KRAMER IRH (1969): Precancerous conditions of the oral mucosa. Ann R Coll Surg Engl 45: 340–356

    PubMed  CAS  Google Scholar 

  • KRAMER IRH, LUCAS RB, EL-LABBAN N, LISTER L (1970): A computer-aided study on the tissue changes in oral keratoses and lichen planus and an analysis of case groupings by subjective and objektive criteria. Br J Cancer 24: 407–426

    PubMed  CAS  Google Scholar 

  • KRAMER IRH, LUCAS RB, EL-LABBAN N, LISTER L (1970): The use of discriminant analysis for examining the histological features of oral keratoses and lichen planus. Br J Cancer 24: 673–683

    PubMed  CAS  Google Scholar 

  • KRAMER IRH (1980): Oral leukoplakia. J R Soc Med 73: 765–767

    PubMed  CAS  Google Scholar 

  • Leroux-Robert J (1936): Les épitheliomas intralaryngés. Formes anatomo-cliniques. Voies d’extension. Thèse pour le doctorat en medicine. Gaston Doin & Cie, Paris

    Google Scholar 

  • LIOTTA LA, TRYGGVASON K, GARBISA S, HART I, FOLTZ CM, SHAFIE S (1980): Metastatic potential correlates with enzymatic degradation on basement membrane collagen. Nature 284: 67–68

    PubMed  CAS  Google Scholar 

  • LIOTTA LA, RAO CN, BARSKY SH (1983): Tumor invasion and the extracellular matrix. Lab Invest 49: 636–649

    PubMed  CAS  Google Scholar 

  • LÖBe L-P, QUADE R (1982): Histopathologisches Grading von Karzinomen des HNO-Gebietes. Laryngol Rhinol Otol 61:171–173

    Google Scholar 

  • LUNDGREN J, OLOFSSON J, HELLQUIST HB, STRAUDH HJ (1981): Exfoliative cytology in laryngology: Comparison of cytologic and histologic diagnoses in 350 microlaryngoscopic examinations — a prospective study. Cancer 47: 1336–1343

    PubMed  CAS  Google Scholar 

  • LUNDGREN J, OLOFSSON J, HELLQUIST H, GRÖNTOFT L (1983): Scanning electron microscopy of vocal cord hyperplasia, keratosis, papillomatosis, dysplasia and carcinoma. Acta Otolaryngol (Stockh) 96: 315–327

    CAS  Google Scholar 

  • MCCOMB WS, FLETCHER GH, GALAGER HS, HEALY JE, LEHMANN OH (1967): Larynx. In: MCCOMB WS, FLETCHER GH (eds): Cancer of the head and neck. Baltimore

    Google Scholar 

  • MCGAVRAN MH, BAUER WC, OGURA JH (1961): The incidence of cervical lymph node metastases from epidermoid carcinoma of the larynx and their relationship to certain characteristics of the primary tumor. Cancer 14: 55–66

    PubMed  CAS  Google Scholar 

  • MAGNUSSON BC, HEYDEN G, SVENSSON S-E (1974): Histochemical observations on 5’-nucleotidase activity in squamous cell carcinomas of the rat. Histochemistry 42:1–8

    PubMed  CAS  Google Scholar 

  • MAKIMOTO K, TAMADA A, KISHIMOTO S, KANOH N, HOSHINO T (1983): Observations on immunologic parameters in laryngeal cancer patients. Arch Otorhinolaryngol 238: 241–250

    PubMed  CAS  Google Scholar 

  • MATTOX DE, VON HOFF DD (1980): In vitro stem cell assay in head and neck squamous carcinoma. Am J Surg 140: 527–530

    PubMed  CAS  Google Scholar 

  • MEYER-BREITING E, HALBSGUTH A, OPRITOIU G (1982): Die Bedeutung der Computertomographie für Diagnostik und Therapieplanung fortgeschrittener Kehlkopfkarzinome. Arch Otorhinolaryngol 235: 689–691

    Google Scholar 

  • MEYER-BREITING E, WEITH E (1982): A whole-organ serial sectioning technique for histologic examination of laryngeal specimen. Arch Otorhinolaryngol 237: 7–15

    Google Scholar 

  • MEYER-BREITING E, WILZ D (1988): Collagenolytic activity in head and neck cancer — study of 100 squamous cell carcinomas. In preparation

    Google Scholar 

  • MITTERMAYER C, HÄRLE F, HAGEDORN M (1981): Versuche einer Objektivierung und Validierung der oralen Leukoplakie. In: PETERS J, MÜLLER R (eds), Präkanzerosen und Papillomatosen der Haut. Springer, Berlin-Heidelberg

    Google Scholar 

  • MICHAELS L, GREGOR Rt (1980): Examination of the larynx in the histopathology laboratory. J Clin Path 33: 705–710

    PubMed  CAS  Google Scholar 

  • MORRA B, BEATRICE F, BRUSSI M, POGGIO E, SARTORIS A, CAVALLO GP, DI FORTUNATO V, VERCELLINO M, CORTESINA G(1984): Evaluation of blocking mechanisms against immunological responses in patients with laryngeal carcinoma. Laryngoscope 94: 825–828

    PubMed  CAS  Google Scholar 

  • MÜNZEL M, MEISTER P (1976): Subepitheliale Veränderungen bei der einfachen leukoplakischen Hyperplasie der Kehlkopfschleimhaut. Laryngol Rhinol Otol 55: 96–99

    Google Scholar 

  • OLDE KALTER P, LUBSEN H, DELEMARRE JFM, ALONS CL, VELDHUIZEN RW, MEYER CJLM, SNOW GB (1985): Quantitative morphometry of squamous cell hyperplasia of the larynx. J Clin Pathol 38: 489–495

    PubMed  CAS  Google Scholar 

  • OLDE KALTER P, DELEMARRE JFM, ALONS CL, MEYER CJLM, SNOW GB (1986): The clinical relevance of classification of squamous cell hyperplasia of the larynx by morphometry. Acta Otolaryngol (Stockh) 101: 331–340

    CAS  Google Scholar 

  • OLOFSSON H,VON NOSTRAND AW (1973): Growth and spread of laryngeal carcinoma with reflections on the effect of pre-operative irradiation. Acta Otolaryngol Suppl (Stockh) 308:1–84

    CAS  Google Scholar 

  • PALMER DL (1978): Alcohol consumption and cellular immunocompetence. Laryngoscope 88 (Suppl8): 13–17

    PubMed  CAS  Google Scholar 

  • PAPENHAUSEN PR, KUKWA A, CROFT CB, BOROWIECKI B, SILVER C, EMESON EE (1979): Cellular immunity in patients with epidermoid cancer of the head and neck. Laryngoscope 89: 538–549

    PubMed  CAS  Google Scholar 

  • PERENYI J (1882): Über eine neue Erhärtungsflüssigkeit. Zool Anz 5: 459–460

    Google Scholar 

  • QUADE R, LÖBE LP (1984): Prognostische Wirksamkeit einer histologisch-zytochemischen Malignitätsgraduierung beim Plattenepithelkarzinom des Kopf-Hals-Bereiches. Acta Histochem (Suppl)(Jena) 30: 81–87

    CAS  Google Scholar 

  • RABIN BS, JOHNSON J, CLAASSEN D (1984): Identification of subsets of lymphocytes infiltrating head and neck tumor tissue: A preliminary report. Laryngoscope 94: 688–690

    PubMed  CAS  Google Scholar 

  • RICHMAN IM, GELFAND M, HILL JM (1947): A method of decalcifying bone for histologic section. Arch Pathol Lab Med 44: 92–95

    CAS  Google Scholar 

  • SAKU T, SATO E (1983): Prediction of malignant change in oral precancerous lesions by DNA cytofluorometry. J Oral Pathol 12: 90–102

    Google Scholar 

  • SCHAUER A, HERRMANN J, FINSTERER H (1973): Zytologische Untersuchungen zur Erkennung praeneoplastischer und neoplastischer Larynxveränderungen. Verh Dtsch Ges Pathol 57: 370–373

    PubMed  CAS  Google Scholar 

  • SCHENK P, KONRAD K (1979): Zur Ultrastruktur der Tumor-Stromagrenze des invasiven Larynxkarzinoms. Laryngol Rhinol Otol 58: 575–582

    CAS  Google Scholar 

  • SCHENK P (1980): Langerhanszellen bei invasivem Larynxkarzinom. Laryngol Rhinol Otol 59: 232–237

    CAS  Google Scholar 

  • SCHENK P (1980): Die Ultrastruktur der Dyskeratose bei invasivem Larynxkarzinom. Laryngol Rhinol Otol 59: 351–355

    CAS  Google Scholar 

  • SCHENK P (1981): Ultrastrukturelle Basallamina-Alterationen an der Tumor-Stromagrenze von invasiven Larynxkarzinomen. Laryngol Rhinol Otol 60: 573–576

    CAS  Google Scholar 

  • SCHENK P (1983): Ultrastrukturelle Alterationen des endoplasmatischen Retikulums in malignen Keratinozyten des Larynxkarzinoms. Laryngol Rhinol Otol 62: 535–539

    CAS  Google Scholar 

  • SCHIFF LJ, SHUGAR MA (1984): Growth of human head and neck squamous cell carcinoma stem cells in agarose. Cancer 53:286–290

    PubMed  CAS  Google Scholar 

  • SCRAGG MA, JOHNSON NW (1980): Epithelial cell kinetics: a review of methods of study and their application to oral mucosa in health and disease. J Oral Pathol 9: 309–341

    PubMed  CAS  Google Scholar 

  • SCRAGG MA, JOHNSON NW (1982): Epithelial cell kinetics. A review of methods of study and their application to oral mucosa in health and disease. J Oral Pathol 11:102–137

    PubMed  CAS  Google Scholar 

  • SCULLY C (1981 A): Serum alkaline desoxyribonuclease in oral cancer and premalignant lesions. Biomedicine 35: 179–180

    PubMed  CAS  Google Scholar 

  • SCULLY C (1981B): Serum beta 2 microglobulin in oral malignancy and premalignancy. J Oral Pathol 10: 354–357

    PubMed  CAS  Google Scholar 

  • SCULLY C (1982A): The immunology of cancer of the head and neck with particular reference to oral cancer. Oral Surg 53:157–169

    PubMed  CAS  Google Scholar 

  • SCULLY C (1982 B): Thymidine kinase activity in oral squamous cell carcinoma. J Oral Pathol 11: 210–213

    PubMed  CAS  Google Scholar 

  • SCULLY C (1982 C): Immunological abnormalities in oral carcinoma and oral keratosis. J Maxillofac Surg 10: 113–115

    PubMed  CAS  Google Scholar 

  • SCULLY C (1983): Immunology and oral cancer. Br J Oral Surg 21:136–146

    PubMed  CAS  Google Scholar 

  • SHKLAR G, EISENBERG E, FLYNN E (1979): Immunoenhancing agents and experimental leukoplakia and carcinoma of the hamster buccal pouch. Prog Exp Tumor Res 24: 269–282

    PubMed  CAS  Google Scholar 

  • SHKLAR G (1981): Modern studies and concepts of leukoplakia in the mouth. J Derm Surg Oncol 7: 996–1003

    CAS  Google Scholar 

  • SILVERMAN NA, ALEXANDER JC, CHRETIEN P (1976): CEA levels in head and neck cancer. Cancer 37: 2204–2211

    PubMed  CAS  Google Scholar 

  • SUGAR J, FARAGO L (1966): Ultrastructure of laryngeal pre-canceroses. Acta Otolaryngol (Stockh) 62: 319–322

    CAS  Google Scholar 

  • TAYLOR CR, KLEDZIG G (1981): Immunhistologic techniques in surgical pathology — a spectrum of “new” special stains. Hum Pathol 12: 590–596

    PubMed  CAS  Google Scholar 

  • TAYLOR SG, SAFFORD PC (1982): Antigen specifity of squamous cancers of the head and neck based on tumor site using the slide leukocyte adherence inhibition assay. J Surg Oncol 20: 41–45

    PubMed  Google Scholar 

  • THOMSEN J, OLSEN J, THOMSEN KA (1975): Exfoliative cytology in the diagnosis of laryngeal malignancy. J Laryngol Otol 89: 281–287

    PubMed  CAS  Google Scholar 

  • THOMSEN J, OLSEN J, SORENSEN H (1976): Replica cytology in cancer of the larynx: an evaluation of a replica method in the diagnosis of laryngeal malignancy. J Otolaryngol 5: 403–409

    PubMed  CAS  Google Scholar 

  • THORPE EJ, BELLOMY BB, SELLERS RF (1963): Ultrasonic de-calcification of bone. J Bone Joint Surg 45 A: 1257–1259

    Google Scholar 

  • TRELL E, BJORLING G, ANDREASSON L, KORSGAARD R, MATTIASSON I (1981): Carcinoma of the oral cavity in relation to arylhydrocarbon-hydroxylase inducibility, smoking and dental status. Int J Oral Surg 10: 93–99

    PubMed  CAS  Google Scholar 

  • TUCKER GF (1961): A histological method for the study of the spread of carcinoma within the larynx. Ann Otol Rhinol Laryngol 70:910–921

    PubMed  Google Scholar 

  • TUCKER GF (1971): Human larynx coronal section atlas. Armed Forces Institute of Pathology, Washington D. C.

    Google Scholar 

  • UNDERWOOD JCE (1974): Lymphoreticular infiltration in human tumours: prognostic and biological implications. Br J Cancer 30: 538–547

    PubMed  CAS  Google Scholar 

  • VISSER R, BEEK JMVD, HAVENITH MG, CLEUTJENS JPM, BOSMAN FT (1985): Immunocytochemical detection of basement membrane antigens in the histopathological evaluation of laryngeal dysplasia and neoplasia. Histopathology 10:171–180

    Google Scholar 

  • WAHI PN, COHEN B, LUTHRA UK, TORLONI H (1971): Histological typing of oral and oropharyngeal tumours. WHO, Geneva

    Google Scholar 

  • WALTER RW, DANIELSON JR (1985): Defective monocyte chemotaxis in patients with epidermoid tumors of the head and neck. Arch Otolaryngol 111: 538–540

    PubMed  CAS  Google Scholar 

  • WANEBO HJ (1979): Immunobiology of head and neck cancer: basic concepts. Head Neck Surg 2: 42–55

    PubMed  CAS  Google Scholar 

  • WATANABE T, IGLEHART JD, BOLOGNESI DP, COX EB, VAUGHN A, HUDSON WR (1983): Elevated serum secretory immunoglobulin A levels in patients with head and neck carcinoma. Otolaryngol Head Neck Surg 91:136–142

    PubMed  CAS  Google Scholar 

  • WHITACKER CW, SIEGLER EE (1956): Exfoliative cytology of the larynx — a preliminary report. Laryngoscope 66: 113–118

    Google Scholar 

  • WOLF CT, CHRETIEN PB, ELIAS EG, MAKUCH RW, BASKIES AM, SPIEGEL HE, WEISS JF (1979): Serum glycoproteins in head and neck squamous carcinoma. Correlation with tumor extent, clinical tumor stage, and T-cell levels during chemotherapy. Am J Surg 138: 489–500

    PubMed  CAS  Google Scholar 

  • WUSTROW TPU, ZENNER H-P (1985): Natural killer cell activity in patients with carcinoma of the larynx and hypopharynx. Laryngoscope 95:1391–1400

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Zentrum der HNO-Heilkunde, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, D-6000, Frankfurt am Main 70, Germany

    Priv.-Doz. Dr. Erhard Meyer-Breiting

  2. Pathologisches Institut, der Universität Bern, Freiburg Str. 30, CH-3010, Bern, Germany

    Professor Dr. Arne Burkhardt

Authors
  1. Priv.-Doz. Dr. Erhard Meyer-Breiting
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  2. Professor Dr. Arne Burkhardt
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© 1988 Springer-Verlag Berlin Heidelberg

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Meyer-Breiting, E., Burkhardt, A. (1988). Particular Problems of Histological Preparation and Assessment: Advanced Methods. In: Tumours of the Larynx. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71100-8_2

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  • DOI: https://doi.org/10.1007/978-3-642-71100-8_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71102-2

  • Online ISBN: 978-3-642-71100-8

  • eBook Packages: Springer Book Archive

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