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T-Cell Development

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Immunology of the Neonate

Abstract

The study of ontogeny of T cells or of any other function has three aspects: the descriptive timing of appearance since inception, the quantitative evaluation of cell numbers, and the functional studies to detect if early functions are qualitatively different from those of the adult (Stutman 1985). The T-cell “deficiency” during the perinatal period has been explained as a consequence of: (a) simple quantitative deficits of the various components involved in the response tested, which may or may not include T cells; (b) some qualitative intrinsic properties of the responding T cells; (c) some peculiar excess of down-regulating influences, and (d) various combinations of the above (Stutman 1985). For a given function, the deficiency is usually multifactorial (see Sect. 4). Although the actual comparisons between species have problems, there is agreement that the onset of immunological functions follows the same sequence in all species, as lymphocytes appear during ontogeny and this is independent of the gestation time or life span of a given species (Solomon 1978). Due to space limitations, I will address only three related aspects of T-cell ontogeny: What is the consensus on T-cell development? What does the thymus export? and What is the nature of postthymic development?

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Authors and Affiliations

  1. Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, 10021, USA

    O. Stutman

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  1. O. Stutman
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Editors and Affiliations

  1. Clinica Pediatrics, Universitá di Pavia, I-27100, Pavia, Italy

    G. Roberto Burgio

  2. Institute of Clinical Microbiology, University of Götebôrg, Guldhedsgatan 10, S-413 46, Göteborg, Sweden

    Lars Åke Hanson

  3. Clinica Pediatrica Ospedale dei Bambini, University of Brescia, Via del Medolo 2, I-25100, Brescia, Italy

    Alberto G. Ugazio

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© 1987 Springer-Verlag Berlin Heidelberg

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Stutman, O. (1987). T-Cell Development. In: Burgio, G.R., Hanson, L.Å., Ugazio, A.G. (eds) Immunology of the Neonate. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71094-0_2

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  • DOI: https://doi.org/10.1007/978-3-642-71094-0_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71096-4

  • Online ISBN: 978-3-642-71094-0

  • eBook Packages: Springer Book Archive

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