Abstract
The intestinal mucosal barrier plays a major role in the body’s local and general defense systems. Any alteration of the immune barrier can be responsible for severe diseases. This mucosal barrier consists of a large population of different cells, mainly lymphocytes, plasmocytes, macrophages, polynuclear cells, and mast cells (Arnaud- Battandier 1984), a fact which distinguishes small intestinal (SI) transplantation from that involving other organs. Surgical improvements and drug developments now enable long-term survival of animals that undergo SI transplantation, including large animals such as pigs (Ricour et al. 1983) or dogs (Cohen et al. 1983; Raju et al. 1984) and rodents (Thiede and Deltz 1978; Schraut et al. 1983; see review by Kirxman 1984). Before the use of immunosuppressive drugs, rejection of small- bowel allografts in experimental animals occurred within 10 days.
Chapter PDF
Similar content being viewed by others
Keywords
- Intestinal Transplantation
- Small Bowel Transplantation
- Swine Leukocyte Antigen
- Intestinal Mucosal Barrier
- Interferon Activity
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
Arnaud-Battandier F (1982) Immunologic characteristics of isolated gut mucosal lymphoid cells. In: Strober W, Hanson LA, Sell KW (eds) Recent advances in mucosal immunity. Raven, New York, pp 287–299
Arnaud-Battandier F (1984) Le système lymphoïde intestinal: conceptions actuelles. Gastroenterol Clin Biol 8: 632–640
Arnaud-Battandier F, Salmon H, Vaiman M, Revillon Y, Gallix P, Olivier M, Ricour C (1985) Small intestinal allotransplantation in swine with cyclosporine treatment: Studies of the intestinal lymphoid populations. Transplant Proc 17: 1440–1441
Bernard S, Lantier I, Bottreau E, Aynaud JM, La Bonnardière C, Ricour C, Arnaud-Battandier F (1985) Influence de la cyclosporine A sur la réponse du porc à l’infection expérimentale par le rotavirus et le Coronavirus G.E.T. In: Journées de la recherche porcine en France. Institut Nationale de la Recherche Agronomique Symp Ser 17: 173–202
Cohen Z, Nordgren SR, Mackenzie RD, Lossing AG, Stiller CR, Langer D (1983) Pharmacokinetics of cyclosporine in a canine intestinal transplantation model. Transplant Proc 15: 3013–3018
Cole GA, Nickell SP, Mokhtarian F, Scheibel LW (1983) Effects of cyclosporine on experimental infections. Transplant Proc 15: 2271–2277
Kirkman RL (1984) Small bowel transplantation. Transplantation 37: 429–433
La Bonnardière C, Laude H (1981) High interferon titer in newborn pig intestine during experimentally induced viral enteritis. Infect Immun 32: 28–31
Raju S, Didlake RH, Cayirli M, Turner MD, Grogan JB, Achord J (1984) Experimental small bowel transplantation utilizing cyclosporine. Transplantation 38: 561–566
Ricour C, Revillon Y, Arnaud-B attandier F, Ghnassia D, Weyne P, Lauffenburger A, Jos J, Fontaine JL, Gallix P, Vaiman M (1983) Successful small bowel allografts in piglets using cyclosporine. Transplant Proc 15: 3019–3026
Salmon H (1982) Characterization of pig lymphocyte receptors for allogeneic and nonallogeneic erythrocytes. I. Apparent common identity of both receptors. Clin Exp Immunol 48: 574–580
Thiede A, Deltz E (1978) Morphological reaction in transplanted small intestine using immuno- enetically defined rat strain combinations. Langenbecks Arch Chir 346: 119
Schraut WH, Rosemurgy AS, Riddell RM (1983) Prolongation of intestinal allograft survival without immunosuppressive drug therapy. Transplantation of small bowel allografts. J Surg Res 34: 597–607
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Arnaud-Battandier, F., Salmon, H., Aynaud, J.M., Bernard, S., Révillon, Y., Ricour, C. (1986). In Vitro and In Vivo Studies of the Mucosal Immune Barrier After Long-Term Small-Bowel Allotransplantation in Pigs Using Cyclosporine. In: Deltz, E., Thiede, A., Hamelmann, H. (eds) Small-Bowel Transplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71087-2_9
Download citation
DOI: https://doi.org/10.1007/978-3-642-71087-2_9
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-71089-6
Online ISBN: 978-3-642-71087-2
eBook Packages: Springer Book Archive