In Vitro and In Vivo Studies of the Mucosal Immune Barrier After Long-Term Small-Bowel Allotransplantation in Pigs Using Cyclosporine

  • F. Arnaud-Battandier
  • H. Salmon
  • J. M. Aynaud
  • S. Bernard
  • Y. Révillon
  • C. Ricour

Abstract

The intestinal mucosal barrier plays a major role in the body’s local and general defense systems. Any alteration of the immune barrier can be responsible for severe diseases. This mucosal barrier consists of a large population of different cells, mainly lymphocytes, plasmocytes, macrophages, polynuclear cells, and mast cells (Arnaud- Battandier 1984), a fact which distinguishes small intestinal (SI) transplantation from that involving other organs. Surgical improvements and drug developments now enable long-term survival of animals that undergo SI transplantation, including large animals such as pigs (Ricour et al. 1983) or dogs (Cohen et al. 1983; Raju et al. 1984) and rodents (Thiede and Deltz 1978; Schraut et al. 1983; see review by Kirxman 1984). Before the use of immunosuppressive drugs, rejection of small- bowel allografts in experimental animals occurred within 10 days.

Keywords

Titration Diarrhea Interferon Cyclosporine Mast 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • F. Arnaud-Battandier
  • H. Salmon
  • J. M. Aynaud
  • S. Bernard
  • Y. Révillon
  • C. Ricour

There are no affiliations available

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