Metabolic Effects of Systemic Venous Drainage in Small-Bowel Transplantation

  • K. K. W. Lee
  • W. H. Schraut
Conference paper


In vascularized transplants of the small bowel, venous outflow from the intestinal graft may be conveyed into either the portal or the systemic venous circulation. Studies on a variety of organ allografts (SAKAI 1970; BOECKX et al. 1975), including small-bowel allografts (KORT et al. 1973; SCHRAUT et al. 1983), have suggested that portal venous drainage confers immunologic benefits which favor prolonged allograft survival. These benefits appear to be minor, however, and may not be sufficient to justify the use of portal drainage in preference to systemic venous drainage in intestinal transplantation (SCHRAUT et al. 1985). Portal drainage, however, reestablishes the physiologic route of venous outflow, whereas systemic drainage creates a partial mesocaval shunt, the metabolic consequences of which have not been studied in detail. Therefore, using the rat model in orthotopic small-bowel transplantation, we compared the metabolic changes following transplantation with portal and with systemic venous drainage. Changes in body weight, blood ammonia levels, serum triglycerides, protein and albumin, maltose absorption, and liver weight were the parameters studied.


Venous Drainage Venous Outflow Intestinal Transplantation Venous Anastomosis Relative Liver Weight 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Boeckx W, Sobis H, Lacquet A, et al (1975) Prolongation of allogeneic heart graft survival in the rat after implantation on portal vein. Transplantation 19: 145–149PubMedCrossRefGoogle Scholar
  2. Herz R, Sautter V, Robert F, et al (1972) The Eck fistula rat: Definition of an experimental model. Eur J Clin Invest 2: 390–397PubMedCrossRefGoogle Scholar
  3. Kort WJ, Westbroeck DL, MacDicken I, Lameijer LDF (1973) Orthotopic total small bowel transplantation in the rat. Eur Surg Res 5: 81–89PubMedCrossRefGoogle Scholar
  4. Lauterburg BH, Sautter V, Preisig R, Bircher J (1976) Hepatic functional deterioration after portacaval shunt in the rat. Effects on sulfobromophthalein transport-maximum, indocyanine green clearance and galactose elimination capacity. Gastroenterology 71: 221–227PubMedGoogle Scholar
  5. Sakai A (1970) Role of the liver in kidney allograft rejection in the rat. Transplantation 9: 333–334CrossRefGoogle Scholar
  6. Schraut WH, Abraham VS, Lee KKW (1985) Portal versus systemic venous drainage for small-bowel allografts. Surgery 98: 579–585PubMedGoogle Scholar
  7. Schraut WH, Rosemurgy AS, Riddell RM (1983) Prolongation of intestinal allograft survival without immunosuppressive drug therapy. J Surg Res 34: 597–607PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • K. K. W. Lee
  • W. H. Schraut

There are no affiliations available

Personalised recommendations