Different Modes of Cyclosporine A Administration in Experimental Small-Bowel Transplantation

  • G. Leimenstoll
  • W. Ch. Preissner
  • G. Loske
  • W. Timmermann
  • P. Schroeder
  • E. Deltz
  • W. Niedermayer
Conference paper

Abstract

According to Gibaldi and Perrier (1975), a two-compartment model can be used to describe the pharmacokinetics of drugs metabolized in the liver, such as cyclosporine A (CsA). Compartment 1 refers to the central compartment (blood or plasma) and compartment 2 refers to the hepatoportal system.

Keywords

Cyclosporine Intralipid 

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References

  1. Fidelus RK, Ferguson RM, Widmer MB, Wee S, Bade FH, Orosz C (1982) Effect of cyclosporin A on murine and human T-helper-cell clones. Transplantation 34 /5: 308–311PubMedCrossRefGoogle Scholar
  2. Gibaldi M, Perrier D (1975) Pharmacokinetics. Deccer, New YorkGoogle Scholar
  3. Kahan BD, van Buren CT, Lin SN, Ono Y, Agostino G, Le Grue SJ, Boihan M, Payne WD, Kerman RH (1982) Immunopharmacological monitoring of cyclosporin A-treated recipients of cadaveric kidney allografts. Transplantation 34 /1: 36–46PubMedCrossRefGoogle Scholar
  4. Wassef R, Cohen Z, Nordgren S, Langer B (1985) Cyclosporine absorption in intestinal transplantation. Transplantation 39 /5: 496–499PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • G. Leimenstoll
  • W. Ch. Preissner
  • G. Loske
  • W. Timmermann
  • P. Schroeder
  • E. Deltz
  • W. Niedermayer

There are no affiliations available

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