Different Modes of Cyclosporine A Administration in Experimental Small-Bowel Transplantation
According to Gibaldi and Perrier (1975), a two-compartment model can be used to describe the pharmacokinetics of drugs metabolized in the liver, such as cyclosporine A (CsA). Compartment 1 refers to the central compartment (blood or plasma) and compartment 2 refers to the hepatoportal system.
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- Gibaldi M, Perrier D (1975) Pharmacokinetics. Deccer, New YorkGoogle Scholar