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Different Modes of Cyclosporine A Administration in Experimental Small-Bowel Transplantation

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Abstract

According to Gibaldi and Perrier (1975), a two-compartment model can be used to describe the pharmacokinetics of drugs metabolized in the liver, such as cyclosporine A (CsA). Compartment 1 refers to the central compartment (blood or plasma) and compartment 2 refers to the hepatoportal system.

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References

  • Fidelus RK, Ferguson RM, Widmer MB, Wee S, Bade FH, Orosz C (1982) Effect of cyclosporin A on murine and human T-helper-cell clones. Transplantation 34 /5: 308–311

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  • Gibaldi M, Perrier D (1975) Pharmacokinetics. Deccer, New York

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  • Wassef R, Cohen Z, Nordgren S, Langer B (1985) Cyclosporine absorption in intestinal transplantation. Transplantation 39 /5: 496–499

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© 1986 Springer-Verlag Berlin Heidelberg

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Leimenstoll, G. et al. (1986). Different Modes of Cyclosporine A Administration in Experimental Small-Bowel Transplantation. In: Deltz, E., Thiede, A., Hamelmann, H. (eds) Small-Bowel Transplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71087-2_33

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  • DOI: https://doi.org/10.1007/978-3-642-71087-2_33

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71089-6

  • Online ISBN: 978-3-642-71087-2

  • eBook Packages: Springer Book Archive

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