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Different Modes of Cyclosporine A Administration in Experimental Small-Bowel Transplantation

  • G. Leimenstoll
  • W. Ch. Preissner
  • G. Loske
  • W. Timmermann
  • P. Schroeder
  • E. Deltz
  • W. Niedermayer

Abstract

According to Gibaldi and Perrier (1975), a two-compartment model can be used to describe the pharmacokinetics of drugs metabolized in the liver, such as cyclosporine A (CsA). Compartment 1 refers to the central compartment (blood or plasma) and compartment 2 refers to the hepatoportal system.

Keywords

Central Compartment Trough Level Central Circulation Intramuscular Route Peripheral Route 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Fidelus RK, Ferguson RM, Widmer MB, Wee S, Bade FH, Orosz C (1982) Effect of cyclosporin A on murine and human T-helper-cell clones. Transplantation 34 /5: 308–311PubMedCrossRefGoogle Scholar
  2. Gibaldi M, Perrier D (1975) Pharmacokinetics. Deccer, New YorkGoogle Scholar
  3. Kahan BD, van Buren CT, Lin SN, Ono Y, Agostino G, Le Grue SJ, Boihan M, Payne WD, Kerman RH (1982) Immunopharmacological monitoring of cyclosporin A-treated recipients of cadaveric kidney allografts. Transplantation 34 /1: 36–46PubMedCrossRefGoogle Scholar
  4. Wassef R, Cohen Z, Nordgren S, Langer B (1985) Cyclosporine absorption in intestinal transplantation. Transplantation 39 /5: 496–499PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • G. Leimenstoll
  • W. Ch. Preissner
  • G. Loske
  • W. Timmermann
  • P. Schroeder
  • E. Deltz
  • W. Niedermayer

There are no affiliations available

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