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Rejection in Orthotopic Small-Bowel Transplantation and Immunosuppression by Cyclosporine A: Evidence for Development of Tolerance Mechanisms

  • W. Ch. Preissner
  • P. Liedgens
  • M. Gundlach
  • E. Schröder
  • H. K. Müller-Hermelink
  • E. Deltz
Conference paper

Abstract

The immunologic response in small-intestine transplantation is characterized by an interaction between rejection and graft-versus-host reaction (GvHR) (Deltz 1981). In a fully allogeneic donor-recipient combination, an interaction of both reactions occurs (Deltz 1984). As has been shown in previous investigations, a GvHR may not develop in the case of strong rejection reactions. In this situation, rejection predominates. Therefore, we investigated rejection after orthotopic small-bowel transplantation and tried to elaborate the patterns of T cell infiltration in the graft in order to characterize the course of rejection without immunosuppression and during administration of cyclosporine A (CsA).

Keywords

Small Bowel Cell Infiltration Lamina Propria Complete Necrosis Rejection Reaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Deltz E (1984) Die allogene Dünndarmtransplantation. Zuckschwerdt, MunichGoogle Scholar
  2. Deltz E, Müller-Hermelink HK, Ulrichs K, Thiede A, Müller-Ruchholtz W (1981) Development of graft-versus-host reaction in various target organs after small intestine transplantation. Transplant Proc 13: 1215–1216PubMedGoogle Scholar
  3. Deltz E, Ulrichs K, Schack T, Friedrichs B, Müller-Ruchholtz W, Müller-Hermelink HK, Thiede A (1986) Graft versus host reaction in small intestine transplantation and possibilities for its circumvention. Am J Surg 151: 379–386PubMedCrossRefGoogle Scholar
  4. Kirkman RL, Lear PA, Madara JC, Tilney NC (1984) Small intestine transplantation in the rat: Immunology and Function. Surgery 96: 280–287PubMedGoogle Scholar
  5. Madara JC, Kirkman RC (1985) Structural and functional evolution of jejunal allograft rejection in rats and the ameliorating effects of cyclosporine therapy. J Clin Invest 75: 502–512PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • W. Ch. Preissner
  • P. Liedgens
  • M. Gundlach
  • E. Schröder
  • H. K. Müller-Hermelink
  • E. Deltz

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