Rejection in Orthotopic Small-Bowel Transplantation and Immunosuppression by Cyclosporine A: Evidence for Development of Tolerance Mechanisms

  • W. Ch. Preissner
  • P. Liedgens
  • M. Gundlach
  • E. Schröder
  • H. K. Müller-Hermelink
  • E. Deltz
Conference paper

Abstract

The immunologic response in small-intestine transplantation is characterized by an interaction between rejection and graft-versus-host reaction (GvHR) (Deltz 1981). In a fully allogeneic donor-recipient combination, an interaction of both reactions occurs (Deltz 1984). As has been shown in previous investigations, a GvHR may not develop in the case of strong rejection reactions. In this situation, rejection predominates. Therefore, we investigated rejection after orthotopic small-bowel transplantation and tried to elaborate the patterns of T cell infiltration in the graft in order to characterize the course of rejection without immunosuppression and during administration of cyclosporine A (CsA).

Keywords

Pneumonia Cyclosporine 

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • W. Ch. Preissner
  • P. Liedgens
  • M. Gundlach
  • E. Schröder
  • H. K. Müller-Hermelink
  • E. Deltz

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