Dosage of Serum Acetylcholine Receptor Antibodies

  • Bernard W. Fulpius

Abstract

Anti-acetylcholine receptor antibodies are usually polyclonal antibodies which are directed against the nicotinic acetylcholine receptor (nAChR) glycoprotein. This definition does not mean that these antibodies necessarily interact with functional parts of the receptor molecule. Anti-nAChR antibodies belong to the G or M class of immunoglobulins, and to any one of their subclasses. Thus, these antibodies represent a rather heterogeneous population of molecules with possibly very different properties if one considers their molecular size, ability to cross the foetoplacental barrier, half-life, resistance to proteolysis, tendency to aggregate and form complexes, capacity to bind complement factors and affinity for the receptor molecule.

Keywords

Germinal Neurol Choline Acetylcholine Acetyl 

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References

  1. Bray JJ, Drachman DB (1982) Binding affinities of anti-acetylcholine receptor autoantibodies in myasthenia gravis. J Immunol 128: 105–110PubMedGoogle Scholar
  2. Cuenoud S, Feltkamp TEW, Fulpius BW, Oosterhuis HJGH (1980) Antibodies to acetylcholine receptor in patients with thymoma but without myasthenia gravis. Neurology 30: 201–203PubMedGoogle Scholar
  3. Drachman B (1981) The biology of myasthenia gravis. Annu Rev Neurosci 4: 195–225PubMedCrossRefGoogle Scholar
  4. Fujii Y, Monden Y, Nakahara K, Hashimoto J, Kawashima Y (1984) Antibody to acetylcholine receptor in myasthenia gravis: production by lymphocytes from thymus or thymoma. Neurology 34: 1182–1186PubMedGoogle Scholar
  5. Fulpius BW, Miskin R, Reich E (1980) Antibodies from myasthenic patients that compete with cholinergic agents for binding to nicotinic receptors. Proc Natl Acad Sci USA 77: 4326–4330PubMedCrossRefGoogle Scholar
  6. Gilhus NE, Aarli J A, Matre R (1983) Myasthenia gravis. Antibodies to skeletal muscle cell surface antigens. J Neu- roimmunol 5: 239–249Google Scholar
  7. Lefvert AK, Bergstrom K, Matell G, Osterman PO, Pirskanen R (1978) Determination of acetylcholine receptor antibody in myasthenia gravis: clinical usefulness and pathogenetic implications. J Neurol Neurosurg Psychiatry 41: 394–403PubMedCrossRefGoogle Scholar
  8. Lefvert AK, Cuenoud S, Fulpius BW (1981) Binding properties and subclass distribution of anti-acetylcholine receptor antibodies in myasthenia gravis. J Neuroimmunol 1: 125–135PubMedCrossRefGoogle Scholar
  9. LiebermanJA, Bradley RJ, Rubinstein M, KaneJM (1984) Antibodies to acetylcholine receptors in tardive dyskinesia. Lancet I: 1066Google Scholar
  10. Limburg PC, The TH, Hummel-Tappel E, Oosterhuis HJGH (1983) Anti-acetylcholine receptor antibodies in myasthenia gravis. Part 1. Relation to clinical parameters in 250 patients. J Neurol Sci 58: 357–370PubMedCrossRefGoogle Scholar
  11. Lindstrom J (1977) An assay for antibodies to human acetylcholine receptor in serum from patients with myasthenia gravis. Clin Immunol Immunopathol 7: 36–43PubMedCrossRefGoogle Scholar
  12. Monnier VM, Fulpius BW (1977) A radioimmunoassay for the quantitative evaluation of anti-human acetylcholine receptor antibodies in myasthenia gravis. Clin Exp Immunol 29: 16–22PubMedGoogle Scholar
  13. Olanow CW, Lane RJM, Roses AD (1982) Thymectomy in late-onset myasthenia gravis. Arch Neurol 39: 82–83PubMedGoogle Scholar
  14. Pizzighella S, Riviera AP, Tridente G (1983) Thymic involvement in myasthenia gravis. Study by immunofluorescent and immunoperoxidase staining. J Neuroimmunol 4: 117–127PubMedCrossRefGoogle Scholar
  15. Smith CIE, Hammarstrom L, Lefvert AK (1985) Bone-marrow grafting induces acetylcholine receptor antibody formation. Lancet I: 978CrossRefGoogle Scholar
  16. Tanaka M, Miyatake T (1983) Anti-acetylcholine receptor antibody in aged individuals and in patients with Down’s syndrome. J Neuroimmunol 4: 17–24PubMedCrossRefGoogle Scholar
  17. Tindall RSA (1980) Humoral immunity in myasthenia gravis: effect of steroids and thymectomy. Neurology 30: 554–557PubMedGoogle Scholar
  18. Tzartos SJ, Seybold ME, Lindstrom JM (1982) Specificities of antibodies to acetylcholine receptors in sera from myasthenia gravis patients measured by monoclonal antibodies. Proc Natl Acad Sci USA 79: 188–192PubMedCrossRefGoogle Scholar
  19. Vincent A (1980) Immunology of acetylcholine receptors in relation to myasthenia gravis. Physiol Rev 60: 756–824PubMedGoogle Scholar
  20. Vincent A, Newsom-Davis J, Newton P, Beck N (1983) Acetylcholine receptor antibody and clinical response to thymectomy in myasthenia gravis. Neurology 33: 1276–1282PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Bernard W. Fulpius

There are no affiliations available

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