Abstract

The clinical picture of anemia with erythroid hyperplasia of the bone marrow, but without excessive hemolysis, has been a puzzle to hematologists for many years. In 1907, Luzzatto described one of the first cases as “pseudoaplastic anemia” [70]. However, it was only in 1941 that this syndrome became generally accepted with the description of 100 cases by Bomford and Rhodes [18]. Originally, cases with folic acid deficiency were included in this “refractory anemia” group. However, with the discovery of folic acid in the late 1940s a clear separation could be made between folic acid deficient myelodysplastic states and refractory anemia. As early as 1953, Block et al. recognized that patients with refractory anemia may develop leukemia [16]. He coined the term “preleukemia” in his report on 12 patients, 11 of whom showed features of refractory anemia.

Key words

Myelodysplastic syndromes leukemia smouldering leukemia chromosomal abnormalities bone marrow histology bone marrow culture myelofibrosis hemochromatosis bone marrow transplantation differentiating agents secondary leukemia leukemogenesis. 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • P. Beris
  • P. A. Miescher
    • 1
  1. 1.Division of HematologyGeneva University HospitalGeneva 4Switzerland

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