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Der Einfluß verschiedener Formen der oralen Dekontamination auf die bakterielle Kolonisation bei Kindern mit Neutropenie

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Ergebnisse der Inneren Medizin und Kinderheilkunde / Advances in Internal Medicine and Pediatrics

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Zusammenfassung

Neben Blutungen sind Infektionen für die schwerwiegendsten Komplikationen und am häufigsten für den Tod von Patienten mit akuten Leukämien verantwortlich [2, 19, 45]. Die starke Infektionsanfälligkeit ist Folge der Granulozytopenie, die durch die Grunderkrankung und durch die zytostatische Therapie bedingt ist [2, 7]. Anämien lassen sich durch Transfusionen gut korrigieren. Eine Verringerung des Infektionsrisikos durch Granulozytenersatz ist schwierig, da durch Granulozytentransfusion viele Nebenwirkungen, wie eine erhöhte Häufigkeit von Zytomegalieinfektionen und pulmonale Reaktionen, und insbesondere auch eine rasche Alloimmunisierung, hervorgerufen werden [39, 88]. Andererseits erscheinen prophylaktische Granulozytengaben nur wenig effektiv [88].

Mit Unterstützung durch die Deutsche Forschungsgemeinschaft Ro 448/3/4

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Authors and Affiliations

  1. Dr. von Haunersches Kinderspital der Universität München, Germany

    B. Kinateder

  2. Kinderpoliklinik der Universität München, Germany

    Ch. Bender-Goetze

  3. Max-v.-Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, Germany

    G. Ruckdeschel

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  1. R. Roos
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  2. B. Kinateder
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  3. Ch. Bender-Goetze
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  4. G. Ruckdeschel
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P. Frick G.-A. von Harnack K. Kochsiek G. A. Martini A. Prader

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Roos, R., Kinateder, B., Bender-Goetze, C., Ruckdeschel, G. (1988). Der Einfluß verschiedener Formen der oralen Dekontamination auf die bakterielle Kolonisation bei Kindern mit Neutropenie. In: Frick, P., von Harnack, GA., Kochsiek, K., Martini, G.A., Prader, A. (eds) Ergebnisse der Inneren Medizin und Kinderheilkunde / Advances in Internal Medicine and Pediatrics. Ergebnisse der Inneren Medizin und Kinderheilkunde. Neue Folge Advances in Internal Medicine and Pediatrics, vol 56. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71054-4_3

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