Zusammenfassung

Das Phänomen der kälteinduzierten Präzipitation von Serumeiweiß wurde 1933 von Wintrobe u. Buell erstmals bei einem Patienten mit multiplem Myelom beobachtet. Lerner, Barnum u. Watson benannten 1947 diese in der Elektrophorese nach Tiselius den Gammaglobulinen zuzuordnenden bei Kälte reversibel ausfallenden Eiweiße Kryoglobuline (Kg). Da sich später zeigte, daß die meisten Kg aus einem oder mehreren Immunoglobulinen (Ig) bestehen, wurde auch die Bezeichnung Kryoimmunglobulin eingeführt. Durch ihren Aufbau aus Ig stellen, immunologisch betraehtet, Kg Antikörper dar und sind demzufolge klar abgrenzbar von anderen in Kälte präzipitierenden Plasmaproteinen, wie gewissen C-reaktiven Protein-Albumin-Komplexen, oder den nicht im Serum, sondern im Plasma identifizierbaren Kryofibrinogenen.

Key words

Kryoglobuline Kryoglobulinämie Purpura Vaskulitis Immunkomplex-Krankheit Rheumafaktor Glomerulonephritis Paraproteine 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • A. Fontana
  • P. J. Grob
  • P. Frick
    • 1
  1. 1.Abteilung für klinische Immunologie, Departement für Innere MedizinUniversitätsspitalZürichSwitzerland

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