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Ergebnisse der Inneren Medizin und Kinderheilkunde / Advances in Internal Medicine and Pediatrics pp 1–31Cite as

Die Kryoglobulinämien

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Zusammenfassung

Das Phänomen der kälteinduzierten Präzipitation von Serumeiweiß wurde 1933 von Wintrobe u. Buell erstmals bei einem Patienten mit multiplem Myelom beobachtet. Lerner, Barnum u. Watson benannten 1947 diese in der Elektrophorese nach Tiselius den Gammaglobulinen zuzuordnenden bei Kälte reversibel ausfallenden Eiweiße Kryoglobuline (Kg). Da sich später zeigte, daß die meisten Kg aus einem oder mehreren Immunoglobulinen (Ig) bestehen, wurde auch die Bezeichnung Kryoimmunglobulin eingeführt. Durch ihren Aufbau aus Ig stellen, immunologisch betraehtet, Kg Antikörper dar und sind demzufolge klar abgrenzbar von anderen in Kälte präzipitierenden Plasmaproteinen, wie gewissen C-reaktiven Protein-Albumin-Komplexen, oder den nicht im Serum, sondern im Plasma identifizierbaren Kryofibrinogenen.

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  1. Abteilung für klinische Immunologie, Departement für Innere Medizin, Universitätsspital, Häldeliweg 4, CH-8044, Zürich, Switzerland

    P. Frick

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  1. A. Fontana
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P. Frick G.-A. von Harnack K. Kochsiek G. A. Martini A. Prader

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Fontana, A., Grob, P.J., Frick, P. (1988). Die Kryoglobulinämien. In: Frick, P., von Harnack, GA., Kochsiek, K., Martini, G.A., Prader, A. (eds) Ergebnisse der Inneren Medizin und Kinderheilkunde / Advances in Internal Medicine and Pediatrics. Ergebnisse der Inneren Medizin und Kinderheilkunde. Neue Folge Advances in Internal Medicine and Pediatrics, vol 56. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71054-4_1

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