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Das Hyper-IgE-Syndrom (Buckley- oder Hiob-Syndrom)

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Book cover Ergebnisse der Inneren Medizin und Kinderheilkunde/Advances in Internal Medicine and Pediatrics

Zusammenfassung

Das Hyper-IgE-Syndrom (HIES) ist wegen der Beteiligung zahlreicherOrgansysteme, des Krankheitsbeginns im frühen Kindesalter und der wahrscheinlichen Erblichkeit eine Erkrankung, die nicht nur bei Pädiatern, sondern auch bei Dermatologen, HNO-Ärzten, Immunologen und Genetikern Aufmerksamkeit erweckt. Kamen bis zum Jahre 1975 Veröffentlichungen über dieses Krankheitsbild ausschließlich aus den USA, so ist seit 1976 eine Zunahme der Publikationen aus dem europäischen Raum zu verzeichnen. Trotz zunehmendem Interesse an dieser Erkrankung ist es bis heute — 20 Jahre nach der Erstbeschreibung — nicht gelungen, die Pathogenese des Syndroms aufzuklären. Somit fehlen zum einen die Voraussetzungen für eine exakte Abgrenzung des HIES gegenüber anderen Krankheitsbildern ähnlicher Symptomatik, die in der Regel ebenfalls auf Defekten des Immunsystems beruhen, zum anderen fehlt ohne exakte pathogenetische Kenntnisse die Möglichkeit einer gezielten, ggf. sogar kausalen Therapie.

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Literatur

  1. Abramson JD, Dahl MV, Walsh G (1982) Antistaphylococcal IgE in patients with eczema, hyperimmunoglobulinemia E and recurrent infections. J Am Acad Dermatol 7: 105–110

    CAS  Google Scholar 

  2. Aiuti F F, Businco L, Fiorilli M et al. (1983) Thymopoietin pentapeptide treatment of primary immunodeficiencies. Lancet 1: 551–555

    PubMed  CAS  Google Scholar 

  3. Aiuti F, Paganelli R, Palmisano L (1983) Complications in primary immunodeficiencies. In: Chandra RK (ed) Primary and secondary immunodeficiency disorders. Livingstone, Edinburgh London Melbourne New York, pp 149–153

    Google Scholar 

  4. Aiuti F, Paganelli R, Le Moli S et al. (1984) Defects of interleukins in immunodeficiencies. In: Griscelli C, Vossen J (eds) Progress in immunodeficiency research and therapy I. Excerpta Medica, Amsterdam New York Oxford, pp 261–266

    Google Scholar 

  5. Ambruso DR, Johnston RB (1983) Defects of phagocyte function. In: Chandra RK (ed) Primary and secondary immunodeficiency disorders. Livingstone, Edinburgh London Melbourne New York, pp 133–148

    Google Scholar 

  6. Armistaed JG, Ewan PW (1983) Suppressor T cell numbers and function in atopic patients with high serum IgE levels. J Clin Lab Immunol 12: 179–185

    Google Scholar 

  7. Baehner RL (1980) Neutrophil dysfunction associated with states of chronic and recurrent infection. Pediatr Clin North Am 27: 337–401

    Google Scholar 

  8. Bale JF, Wilson JF, Hill HR (1977) Fatal histiocytic lymphoma of the brain associated with hyperimmunoglobulinemia E and recurrent infections. Cancer 39: 2386–2390

    Google Scholar 

  9. Barrett D (1983) Deficiency of suppressor T cells in hyperimmunoglobulin E syndrome. In: Oski FA, Stockmann JA III (eds) The year book of pediatrics. Year Book Medical Publishers, Chicago London, pp 109–112

    Google Scholar 

  10. Belohradsky BH (1985) Klinisch anwendbare Immunglobuline. Futuramed, München Immunglobuline. Futuramed, München

    Google Scholar 

  11. Berger M, Kirkpatrick CH, Goldsmith PK, Gallin JI (1980) IgE antibodies to staphylococcus aureus and candida albicans in patients with the syndrome of hyper-immunoglobulin E and recurrent infections. J Immunol 125: 2437–2443

    CAS  Google Scholar 

  12. Blum R, Geller G, Fish LA (1977) Recurrent severe staphylococcal infections, eczematoid rash, extreme elevations of IgE, eosinophilia, and divergent chemotactic responses in two generations. J Pediatr 90: 607–609

    PubMed  CAS  Google Scholar 

  13. Brestel EP, Klingberg WG, Veltri RW, Dorn JD (1982) Osteogenesis imperfecta tarda in a child with hyper-IgE syndrome. Am J Dis Child 136: 774–776

    PubMed  CAS  Google Scholar 

  14. Buckley RH (1980) Disorders of the IgE system. In: Stiehm ER, Fulginiti VA (eds) Immunologic disorders in infants and children, 2nd edn. Saunders, Philadelphia London Toronto, pp 274–285

    Google Scholar 

  15. Buckley RH (1980) Immunologic studies in 21 patients with the hyper IgE syndrome. In: Seligmann M, Hitzig WH (eds) Primary immunodeficiencies. Inserm Symposium No 16, Elsevier/North-Holland, New York Oxford, pp 494–496

    Google Scholar 

  16. Buckley RH, Becker WG (1978) Abnormalities in the regulation of human IgE synthesis. Immunol Rev 41: 288–314

    PubMed  CAS  Google Scholar 

  17. Buckley RH, Fiscus SA (1975) Serum IgD and IgE concentrations in immunodeficiency diseases. J Clin Invest 55: 157–165

    PubMed  CAS  Google Scholar 

  18. Buckley RH, Sampson HA (1981) The hyperimmunoglobulinemia E syndrome. In: Franklin EC (ed) Clinical immunology update. Elsevier/North-Holland. New York, pp 147–167

    Google Scholar 

  19. Buckley RH, Wray BB, Belmaker EZ (1972) Extreme hyperimmunoglobulinemia E and undue susceptibility to infection. Pediatrics 49: 59–70

    CAS  Google Scholar 

  20. Buckley RH, Sampson HA, Fisher PH, Becker G, Shirley LR (1982) Abnormalities in the regulation of human IgE synthesis. Ann Allergy 49: 67–72

    PubMed  CAS  Google Scholar 

  21. Buckley RH, Gard S, Schiff RI, Sampson HA (1983) T cells and T-cell subsets in a large population of patients with primary immunodeficiency. Birth Defects 19: 187–191

    PubMed  CAS  Google Scholar 

  22. Burdach S EG, Rister M, Evers KG (1981) Membraneigenschaften der Granulozyten bei einem Hiob-Syndrom mit E. coli-Sepsis. Monatsschr Kinderheilkd 129: 229–232

    CAS  Google Scholar 

  23. Burgio GR, Nespoli L, Ugazio AG (1978) Atopy as a minimal immunodeficiency? Eur J Pediatr 129: 221–229

    PubMed  CAS  Google Scholar 

  24. Businco L, Laurenti F, Rossi P, Galli E, Aiuti F (1981) Clinical and immunologic studies in a patient with hyper-IgE syndrome treated with levamisole. Arch Dis Child 56: 60–63

    PubMed  CAS  Google Scholar 

  25. Caldwell JH, Sharma AM, Hurtubise PE, Colwell DL (1979) Eosinophilic gastroenteritis in extreme allergy. Gastroenterology 77: 560–564

    PubMed  CAS  Google Scholar 

  26. Cates KL (1981) Defects in neutrophil Chemotaxis. In: Webster ABD (ed) Clinics in immunology and allergy. Saunders, London Philadelphia Toronto, pp 609–614

    Google Scholar 

  27. Charette RP, Hill HR (1982) Clinical conditions associated with depressed Chemotaxis. In: Wedgwood E, Davis SD, Ray CC, Kelley VC (eds) Infections in children. Harper & Row, Philadelphia Cambridge New York, pp 110–111

    Google Scholar 

  28. Chikazawa S, Nunoi H, Endo F, Matsuda I, Honda M (1984) Hyperimmunoglobulin-E-associated recurrent infection syndrome accompanied by chemotactic inhibition of polymorphonuclear leukocytes and monocytes. Pediatr Res 18: 365–369

    PubMed  CAS  Google Scholar 

  29. Church JA, Bellanti JA (1977) Selective food-specific IgE antibodies in a patient with hyperimmunoglobulinemia E recurrent infections and severe eczema. Ann Allergy 39: 137–138

    CAS  Google Scholar 

  30. Church JA, Frenkel LD, Wright DG, Bellanti JA (1976) T-lymphocyte dysfunction, hyperimmunoglobulinemia E, recurrent bacterial infections, and defective neutrophil Chemotaxis in a negro child. J Pediatr 88: 982–985

    PubMed  CAS  Google Scholar 

  31. Clark RA, Root RK, Kimball HR, Kirkpatrick CH (1973) Defective neutrophil Chemotaxis and cellular immunity in a child with recurrent infections. Ann Intern Med 78: 515–519

    PubMed  CAS  Google Scholar 

  32. Constantopoulos A, Karpouzas J, Xypolita A, Mandalenaki-Lambrou C, Montsaniotis N, (1978) Defective neutrophil Chemotaxis and hyperimmunoglobulinemia E in a child with recurrent infections. Helv Paediatr Acta 33: 81–84

    CAS  Google Scholar 

  33. Czarnetzki BM, Kownatzki E, Dierich M, Frei PC (1983) Chemotaxis: Basic aspects of methodology, mechanisms and pathology. Arch Dermatol Res 275: 359–364

    Google Scholar 

  34. Däumling S, Buriot D, Huu Trung P, Griscelli C, Lalama MC, Belohradsky BH (1980) Das Buckley-Syndrom: Rezidivierende, schwere Staphylokokkeninfektionen, Ekzem und Hyperimmunglobulinämie E. Infection [Suppl] 8 /3: 248–254

    Google Scholar 

  35. Däumling S, Hess J, Griscelli C, Belohradsky BH (1984) Das Hyper IgE-Syndrom. Infektionsimmunologische Charakterisierung von 21 Patienten ( Abstracts ). Monatsschr Kinderheilkd 132: 714

    Google Scholar 

  36. Dahl MV (1983) Staphylococcus aureus und atopic dermatitis. Arch Dermatol 119: 840–846

    PubMed  CAS  Google Scholar 

  37. Dahl MV, Matula C, Leonards R, Tuffanelli DL (1975) Incontinentia pigmenti and defective neutrophil Chemotaxis. Arch Dermatol 111: 1603–1605

    PubMed  CAS  Google Scholar 

  38. Dahl MV, Greene WH, Quie PG (1976) Infection, dermatitis, increased IgE, and impaired neutrophil Chemotaxis. A possible relationship. Arch Dermatol 112: 1387–1390

    PubMed  CAS  Google Scholar 

  39. Davies EG, Levinsky RJ (1984) Natural killer cell activity in primary immunodeficiency diseases. In: Griscelli C, Vossen J (eds) Progress in immunodeficiency research and therapy I. Medica, Amsterdam New York Oxford, pp 117–123

    Google Scholar 

  40. Davis SD, Schaller J, Wedgwood RJ (1966) Job’s syndrome: Recurrent, “cold”, staphylococcal abscesses. Lancet 1: 1013–1015

    Google Scholar 

  41. De Cree J, Emmery L, Timmermans J, Eeckels R, De Cook W, Verhaegen H (1978) Defective neutrophil Chemotaxis and raised serum IgE levels in a child with recurrent bacterial infections and eczema. Influence of levamisole. Arch Dis Child 53: 144–149

    PubMed  Google Scholar 

  42. Deguchi H, Suemura M, Ishizaka A, Ozaki Y, Kishimoto S, Yamamura Y, Kishimoto T (1983) IgE class-specific suppressor T cells and factors in humans. J Immunol 131: 2752–2756

    Google Scholar 

  43. Donabedian H, Gallin JI (1982) Mononuclear cells from patients with the hyperimmunoglobulin E–recurrent infection syndrome produce an inhibitor of leukocyte Chemotaxis. J Clin Invest 69: 1155–1163

    PubMed  CAS  Google Scholar 

  44. Donabedian H, Gallin JI (1983) The hyperimmunoglobulin E recurrent-infection (Job’s) syndrome. A review of the NIH experience and the literature. Medicine (Baltimore) 62: 195–208

    Google Scholar 

  45. Donabedian H, Allin DW, Gallin JI (1982) Levamisole is inferior to placebo in the hyperimmunoglobulin E recurrent-infection ( Job’s) syndrome. N Engl Med 307: 290–292

    CAS  Google Scholar 

  46. Donabedian H, Allin DW, Gallin JI (1982) Levamisole in Job’s syndrome. N Engl J Med 307: 1529

    Google Scholar 

  47. Fanconi S, Seger RA, Willi U, Otto R, Spiess H, Kayser FH, Hitzig WH (1984) Oral Chloramphenicol therapy for multiple liver abscesses in hyperimmunglobulinemia E syndrome. Eur J Pediatr 142: 292–295

    CAS  Google Scholar 

  48. Farhoudi A, Harvey BAM, Soothill JF (1978) Clinopathological findings in patients with primary and secondary defects of neutrophil mobility. Arch Dis Child 53: 625–630

    Google Scholar 

  49. Fasth A (1982) Primary immunodeficiency disorders in Sweden: Cases among children, 1974–1979. J Clin Immunol 2: 86–92

    PubMed  CAS  Google Scholar 

  50. Fasth A (1984) Immunodeficiency in children in Sweden: 1974–1983. In: Griscelli C, Vossen J (eds) Progress in immunodeficiency research and therapy I. Excerpta Medica, Amsterdam New York Oxford, pp 461–467

    Google Scholar 

  51. Fontan G, Lorente F, Garcia Rodriguez MC, Ojeda JA (1976) Defective neutrophil Chemotaxis and hyperimmunoglobulinemia E-a reversible defect? Acta Paediatr Scand 65: 509–511

    PubMed  CAS  Google Scholar 

  52. Foster SC, Goetzl EJ (1978) Ascorbate therapy in impaired neutrophil and monocyte Chemotaxis. Arch Ophthalmol 96: 2069–2072

    PubMed  CAS  Google Scholar 

  53. Friedenberg WR, Marx JJ, Hansen RL, Haselby RC (1979) Hyperimmunoglobulin E syndrome: Response to transfer factor and ascorbic acid therapy. Clin Immunol Immunopathol 12: 132–142

    Google Scholar 

  54. Gahr M, Ranti J, Schröter W (1978) A new defect of neutrophil Chemotaxis and random motility in a child with recurrent bacterial infections and hyperimmunoglobulinemia E. Eur J Pediatr 127: 173–179

    CAS  Google Scholar 

  55. Gaither TA, Gallin JI, Iida K, Nussenzweig V, Frank MM (1984) Deficiency in C3b receptors on neutrophils of patients with chronic granulomatous disease and hyperimmunoglobulin-E recurrent infection ( Job’s) syndrome. Inflammation 8: 429–444

    PubMed  CAS  Google Scholar 

  56. Gallin JI (1980) Disorders of phagocyte Chemotaxis. NIH conference. Ann Intern Med 92: 520–538

    PubMed  CAS  Google Scholar 

  57. Gallin JI (1981) Abnormal phagocyte Chemotaxis: Pathophysiology, clinical manifestations and management of patients. Rev Infect Dis 3 /6: 1196–1220

    PubMed  CAS  Google Scholar 

  58. Geha RS, Reinherz E, Leung D, McKee KT, Schlossman S, Rosen FS (1981) Deficiency of suppressor T cells in the hyperimmunoglobulin E syndrome. J Clin Invest 68: 783 — 791

    CAS  Google Scholar 

  59. Gerbeaux J, Baculard A, Tournier G, Moulias R, Goust J-M, Drouhet E, Saint-Martin J (1975) Déficit partiel de l’immunité à méditation cellulaire chez un enfant atteint de Candidose cutanéomuqueuse chronique. Cryptococcose pulmonaire et méningée intercurrente. Ann Méd Interne (Paris) 10: 615–625

    Google Scholar 

  60. Gillet P, Phillipe N, Philip T (1979) Infection récidivante, éczéma, atopique, défizit du chimiotactisme et hyper IgE sérique-à propos d’une observation chez un garçon de 5 ans. Nouv Rev Fr Hématol 21: 53

    Google Scholar 

  61. Goldman AS, Lord RA, Dupree E, Goldblum RM, Smith CW, Dahl EV (1974) Lack of suppression of certain immunoglobulin-producing lymphocytes in T-lymphocyte deficiency. Clin Immunol Immunopathol 3: 69–78

    PubMed  CAS  Google Scholar 

  62. Gottlieb BR, Hanifîn JM (1974) Circulating T-cell deficiency in atopic dermatitis. Clin Res 22: 159A

    Google Scholar 

  63. Gupta S (1981) Subpopulations of human T-lymphocytes. XVIII. T-lymphocytes with receptors for IgE (Ta) in patients with primary immunodeficiency and hyperimmunoglobulinaemia E states. Clin Exp Immunol 45: 113–117

    CAS  Google Scholar 

  64. Haneke E, Djawari D (1982) Hyperimmunglobulin E-Syndrom: Atopisches Ekzem, Eosinophilie, Chemotaxisdefekt. Infektanfälligkeit und chronische mucocutane Candidose. Aktuel Dermatol 8: 34–39

    Google Scholar 

  65. Hayakawa H (1982) The immunodeficiency syndrome. Asian Med J 25: 278–285

    Google Scholar 

  66. Hayakawa H, Iwata T, Yata J, Kobayashi N (1981) Primary immunodeficiency syndrome in Japan. I. Overview of a nationwide survey on primary immunodeficiency syndrome. J Clin Immunol 1: 31–39

    PubMed  CAS  Google Scholar 

  67. Hénocq E, Hewitt B, Guerin B (1982) Staphylococcal and human IgE antibodies in superinfected atopic dermatitis. Clin Allergy 12: 113–120

    PubMed  Google Scholar 

  68. Hill HR (1982) The syndrome of hyperimmunglobulinemia E and recurrent infections. Am J Dis Child 136: 767–771

    CAS  Google Scholar 

  69. Hill HR, Quie PG (1974) Raised serum-IgE levels and defective neutrophil Chemotaxis in three children with ekzema and recurrent bacterial infections. Lancet 1: 183–187

    PubMed  CAS  Google Scholar 

  70. Hill HR, Quie PG (1974) Defective neutrophil Chemotaxis, severe staphylococcal infection and hyperimmunoglobulinemia E. Pediatr Res 8: 426

    Google Scholar 

  71. Hill HR, Quie PG (1974) Impaired neutrophil granulocyte Chemotaxis, recurrent bacterial and fungal infections and hyperimmunoglobulinemia E. Clin Res 22: 229

    Google Scholar 

  72. Hill HR, Ochs HD, Quie PG, Clark RA, Pabst HF, Kebanoff SJ, Wedgwood RJ (1974) Defect in neutrophil granulocyte Chemotaxis in Job’s syndrome of recurrent “cold” staphylococcal abscesses. Lancet 1: 617–619

    Google Scholar 

  73. Hill HR, Estensen RD, Hogan NA, Quie PG (1976) Severe staphylococcal disease associated with allergic manifestations, hyperimmunoglobulinemia E, and defective neutrophil Chemotaxis. J Lab Clin Med 88: 796–806

    PubMed  CAS  Google Scholar 

  74. Huu Trung P, Oury C, Däumling S, Buriot D, Belohradsky BH, Griscelli C (1982) Syndrome de susceptibilité aux infections avec hyper IgE. Arch Fr Pediatr 39: 353–358

    Google Scholar 

  75. Ishikawa I, Fukuda Y, Kitada H et al. (1982) Plasma exchange in a patient with hyper-IgE syndrom. Ann Allergy 49 /5: 295–297

    PubMed  CAS  Google Scholar 

  76. Tssekutz AC, Lee KY, Biggar WD (1978) Neutrophil Chemotaxis in two patients with recurrent staphylococcal skin infections and hyperimmunoglobulin E. J Lab Clin Med 92: 640–647

    Google Scholar 

  77. Jacobs JC, Norman ME (1977) Familial defect of neutrophil Chemotaxis, with asthma, eczema, and recurrent skin infection. Pediatr Res 11: 732–736

    PubMed  CAS  Google Scholar 

  78. Jeune R, Faure M, Leung-Tack J (1978) Defective leukocytotaxia and recurrent staphylococcal infection. Arch Dermatol 114: 1372–1378

    PubMed  CAS  Google Scholar 

  79. Josephs SH, Buckley RH (1980) Serum IgD concentration in normal infants, children, and adults and in patients with elevated IgE. J Pediatr 96: 417–420

    PubMed  CAS  Google Scholar 

  80. Jung LKL, Kapoor N, Engelhard D, Pih K, Good RA (1983) Pyoderma, eczema, and follikulitis with defective leukocyte and lymphocyte function: A new familial immunodeficiency disease responsive to a histamine–1 antagonist. Lancet 1: 185–187

    Google Scholar 

  81. Katona IM, Tata G, Scanion RT, Bellanti JA (1980) Hyper IgE syndrome: A disease with suppressor T cell deficiency. Ann Allergy 45: 295–300

    Google Scholar 

  82. Katz DH (1984) Regulation of the IgE-system: Experimental and clinical aspects. Allergy 39: 81–106

    PubMed  CAS  Google Scholar 

  83. Kesarwala HH, Prasad RVSK, Szep R, Oldman E, Lane S, Papageorgiou PS (1979) Transfer factor therapy in hyperimmunoglobulinemia E syndrome. Clin Exp Immunol 36: 465–472

    CAS  Google Scholar 

  84. Koch C, Andersen V, Faber V, Friis B, Pedersen FK, Platz P (1981) Registration of primary immunodeficiencies. Ugeskr Laeger 143: 2479–2484

    PubMed  CAS  Google Scholar 

  85. Komiyana A, Morosawa H, Manamura K, Miyagawa Y, Akabane T (1977) Defective neutrophil Chemotaxis, hyperimmunoglobulinemia and impair cellular immunity in a child with recurrent pyogenic infections and chronic eczema. Acta Haematol Jpn 40: 513–539

    Google Scholar 

  86. Kraemer MJ, Ochs HD, Furukawa CT, Wedgwood RJ (1982) In vitro studies of the hyper-IgE disorders: Suppression of spontaneous IgE synthesis by allogeneic suppressor T-lymphocytes. Clin Immunol Immunopathol 25: 157–164

    Google Scholar 

  87. Lallemand D, Buriot D, Griscelli C, Kalifa G, Sauvergrain J (1979) Anomalies osseuses constitutionelles dans les déficits immunitaires congénitaux. Ann Radiol 22: 108–118

    PubMed  CAS  Google Scholar 

  88. Laurent J, Lagrue G, Dubertret L, Branellec A (1983) Syndrome d’hyperimmunoglobulinémia E avec infections récurrentes (syndrome de Buckley) associé à une glomérulonephrite membranoproliferative. Presse Méd 12: 1005–1007

    CAS  Google Scholar 

  89. Leyh F, Wendt V, Otte J (1984) Lupus erythematodes in Kombination mit Hyper-IgE-Syndrom ( Abstracts ). Monatsschr Kinderheilkd 132: 701

    Google Scholar 

  90. Lipinski M, Virelizier JL, Tursz T, Griscelli C (1980) Natural killer cells and killer cell activities in patients with primary immunodeficiencies or defects in interferon production. Eur J Immunol 10: 246–249

    PubMed  CAS  Google Scholar 

  91. Luzi G, Businco L, Aiuti F (1983) A national registry for primary immunodeficiency syndromes in Italy: A report for the period 1972–1982. Birth Defects 19: 161–163

    PubMed  CAS  Google Scholar 

  92. Matsumoto T, Gotoh Y, Narukami H, Miyamoto V, Honda M (1981) Case report: A hyperimmunoglobulin E syndrome with serum inhibitor against immune functions. Ann Allergy 46: 86–91

    Google Scholar 

  93. Mawhinney H, Killen M, Fleming WA, Roy AD (1980) The hyperimmunoglobulin E syndrome–a neutrophil chemotactic defect reversible by histamine H2 receptor blockade? Clin Immunol Immunopathol 17: 483–491

    PubMed  CAS  Google Scholar 

  94. Merten DF, Buckley RH, Pratt PC, Effmann EL, Grossman H (1979) Hyperimmunoglobulinemia E syndrome: Radiographic observations. Radiology 132: 71–78

    PubMed  CAS  Google Scholar 

  95. Miller ME (1975) Pathology of Chemotaxis and random mobility. Sem Hematol 12: 59–82

    CAS  Google Scholar 

  96. Ochs HD, Kraemer MJ, Landgren CG, Furukawa CT, Wedgood RJ (1983) Immune regulation in the hyper-IgE/Job syndrome. Birth Defects 19: 57–61

    PubMed  CAS  Google Scholar 

  97. Ortega JJ, Félin E, Espanol T, Cardellach F (1980) Hiperimmunoglobulinemia E y quiemiotaxis defectuosa asociadas a infecciones bacteriamas récurrentes y asma. Sangra 25: 231–239

    CAS  Google Scholar 

  98. Pabst HF, Holmes B, Quie PG, Gewürz H, Rodey G, Good RA (1971) Immunological abnormalities in Job’s syndrome. Pediatr Res 6: 380

    Google Scholar 

  99. Paslin D, Norman ME (1977) Atopic dermatitis and impaired neutrophil Chemotaxis in Job’s syndrome. Arch Dermatol 113: 801–805

    PubMed  CAS  Google Scholar 

  100. Patrone F, Dallegri F, Rebora A (1979) Defective neutrophil Chemotaxis and bactericidial power in a child with hyperimmunoglobulinemia E. Eur J Pediatr 180: 181–187

    Google Scholar 

  101. Perraudin ML. Larregue M, Huu Trung P, Desbois JC, Herrault A (1980) Infections recidivantes avec hypergammaglobulinemie E, syndrome de Buckley. Nouv Presse Med 9:1571–1575

    Google Scholar 

  102. Pincus SH, Thomas IT, Clark RA, Ochs HD (1975) Defective neutrophil Chemotaxis with variant ichthyosis, hyperimmunoglobulinemia E, and recurrent infections. J Pediatr 87: 908–911

    PubMed  CAS  Google Scholar 

  103. Pohl P (1983) Differentialdiagnose von Abwehrdefekten. In: Huber H, Pastner D, Gabi F (Hrsg) Hämatologie und Immunhämatologie. Springer, Berlin Heidelberg New York Tokyo, S 200–234

    Google Scholar 

  104. Quie PG (1983) Hyperimmunglobulin E recurrent infection (Job) syndrome. In: Behrman RE, Vaughan VC III, Nelson WA (eds) Textbook of pediatrics. Saunders, Philadelphia London Toronto Mexico City Rio de Janeiro Sydney Tokyo, p 522

    Google Scholar 

  105. Quie PG (1983) Infections in patients with abnormal granulocyte Chemotaxis. In: Gigli IN, Miescher PA, Müller-Eberhard HJ (eds) Immunodermatology. Springer, Berlin Heidelberg New York Tokyo, pp 117–128

    Google Scholar 

  106. Raynor RH, Wray BB, Brown WG, Scott DF, Best GK (1980) Neutrophil function studies in patients with elevated serum IgE levels and recurring staphylococcus aureus infections. Clin Immunol Immunopathol 17: 372–381

    PubMed  CAS  Google Scholar 

  107. Rebora A, Patrone F (1978) Hyperimmunoglobulinemia E syndrome. Arch Dermatol 114: 1854

    CAS  Google Scholar 

  108. Rebora A, Nunzi E, Pezzuolo M, Patrone F, Dallegri F, Sacchetti C (1978) Buckley’s syndrome. Br J Dermatol 99: 569–572

    PubMed  CAS  Google Scholar 

  109. Repine JE, Clawson CC, Brunning RD (1976) Primary leukocyte alkaline phosphatase deficiency in an adult with repeated infections. Br J Haematol 34: 87–94

    PubMed  CAS  Google Scholar 

  110. Rister M, Horatz M (1981) Adhärenz und Chemotaxis kindlicher Granulozyten. Klin Pädiatr 193: 46–49

    PubMed  CAS  Google Scholar 

  111. Rogge JL, Hanifin JM (1976) Immunodeficiencies in severe atopic dermatitis. Depressed Chemotaxis and lymphocyte transformation. Arch Dermatol 112: 1391–1396

    PubMed  CAS  Google Scholar 

  112. Romagnani S, Maggi E, del Prete GF, Ricci M (1983) IgE synthesis in vitro induced by T cell factors from patients with elevated serum IgE levels. Clin Exp Immunol 52: 85–88

    PubMed  CAS  Google Scholar 

  113. Sacchi FT, Ferrari FA, Fortunato A, Maggiore G, Marconi H, Pagani A, Siccardi AG (1979) A defect in neutrophil motility in two siblings with recurrent infections and a remarkable family history. Infection 7: 45–47

    PubMed  CAS  Google Scholar 

  114. Saryan JA, Leung DYM, Geha RS (1983) Induction of human IgE synthesis by a factor derived from T–cells of patients with hyper–IgE states. J Immunol 130: 242–247

    PubMed  CAS  Google Scholar 

  115. Schmitt C, Ballet JJ (1983) Serum IgE and IgG antibodies to tetanus toxoid and candida in immunodeficient children with the hyper–IgE syndrome. J Clin Immunol 3: 178–183

    PubMed  CAS  Google Scholar 

  116. Schopfer K (1984) Le syndrome de susceptibilité aux infections avec hyper-IgE. In: Griscelli C, Hitzig W (eds) Déficits immunitaires congénitaux et acquis. Doin, Paris, pp 141–156

    Google Scholar 

  117. Schopfer K, Baerlocher K, Price P, Krech U, Quie PG, Douglas SD (1979) Staphylococcal IgE antibodies hyperimmunoglobulinemia E and staphylococcus aureus infections. N Engl J Med 300: 835–838

    CAS  Google Scholar 

  118. Schopfer K, Douglas SD, Wilkinson BJ (1980) Immunoglobulin E antibodies against staphylococcus aureus cell walls in the sera of patients with hyperimmunoglobulinemia E and recurrent staphylococcal infection. Infect Immunol 27: 563–568

    CAS  Google Scholar 

  119. Schopfer K, Feldges A, Baerlocher K, Porisot RF, Wilhelm JA, Matter L (1983) Systemic lupus erythematosus in staphylococcal aureus hyperimmunglobulinemia E syndrome. Br Med J 287: 524–526

    CAS  Google Scholar 

  120. Sheagren JN (1984) Staphylococcus aureus. The persistent pathogen. N Engl J Med 310: 1368–1373

    PubMed  CAS  Google Scholar 

  121. Smithwick EM, Finelt M, Pahwa S, Good RA (1978) Cranial synostosis in Job’s syndrome. Lancet 1: 826

    PubMed  CAS  Google Scholar 

  122. Snyderman R, Buckley RH (1975) Defects of monocyte Chemotaxis in patients with hyperimmunoglobulinemia E and undue susceptibility to infections. J Allergy Clin Immunol 55: 102–103

    Google Scholar 

  123. Soderberg-Warner M, Price-Mendoza CA, Mendoza GR, Stiehm ER (1983) Neutrophil and T–lymphocyte characteristics of two patients with hyper-IgE-syndrome. Pediatr Res 17: 820–824

    PubMed  CAS  Google Scholar 

  124. Spector BD, Perry GS III, Kersey JH (1978) Genetically determined immunodeficiency diseases ( GDID) and malignancy: Report from the immunodeficiency-cancer registry. Clin Immunol Immunopathol 11: 12–29

    PubMed  CAS  Google Scholar 

  125. Stanley J, Perez D, Gigli I, Goldstein I, Baer RL (1978) Hyperimmunoglobulin E syndrome. Arch Dermatol 114: 765–767

    CAS  Google Scholar 

  126. Swim AT, Bradac C, Craddock PR (1982) Levamisole in Job’s syndrome. N Engl J Med 307: 1528–1529

    PubMed  CAS  Google Scholar 

  127. Tonnel AB, Joseph M, Gosselin B, Gösset P, Fournier E (1983) Pneumatocêle surinfectée, éosinophilie et hyperproduction dTgE révélatrices d’un syndrome de Buckley à 1’ age adulte. Poumon Coeur 39: 95–100

    PubMed  CAS  Google Scholar 

  128. Van der Meer JWM, van den Broek PJ (1984) Present status of the management of patients with defective phagocyte function. Rev Infect Dis 6: 107–121

    PubMed  Google Scholar 

  129. Van Epps DE, El-Naggar A, Ochs HD (1983) Abnormalities of lymphocyte locomotion in immunodeficiency disease. Clin Exp Immunol 53: 678–688

    Google Scholar 

  130. Vanheule R, De Cree J, Adriaenssens K, De Hauwere R (1976) Levamisole therapy for cellular immunologic deficiency with high IgE values. Acta Paediatr Belg 29: 41–46

    PubMed  CAS  Google Scholar 

  131. Van Scoy RE, Hill MR, Ritts RE (1975) Familial neutrophil Chemotaxis defect, recurrent bacterial infections, mucocutanous candidiasis, and hyperimmunoglobulinemia E. Ann Intern Med 82: 766–771

    Google Scholar 

  132. Viniaker H, Moneret-Vautrin DA, Le Van Diem, Grilliat J (1976) Taux élevé d’IgE, hyperéosinophilie et déficit de l’immunité cellulaire. Ann Méd Nancy 3: 225–229

    Google Scholar 

  133. Waldmann TA, Wochner RD, Laster L, Gordon RS (1967) Allergie gastroenteropathy. A cause of excessive gastrointestinal protein loss. N Engl J Med 276: 761–769

    Google Scholar 

  134. Weening RS, Stricker L, Roos D, Molenaar JL, Dooren LJ, Schuurman RKB (1977) Restoration of the neutrophil chemotactic responsiveness by levamisole treatment in patients with recurrent infections, eczema and hyperimmunoglobulinaemia E. In: Willoughby DA, Giroud JP, Velo GP (eds) Perspectives in inflammation. MTP Press, Lancaster, pp 445–454

    Google Scholar 

  135. Wenning J, Stengel R, Kunze J, Schöpf E (1981) Hyperimmunglobulin E-Syndrom. In: Z. Kölner-RAST-Symposion 1979. Grosse, Berlin, S 74–78

    Google Scholar 

  136. Weston WL, Humbert JR, August CS, Harnett J, Hass MF, Dean PB, Hagen IM (1977) A hyperimmunoglobulin E syndrome with normal Chemotaxis in vitro and defective leukotaxis in vivo. J Allergy Clin Immunol 59: 115–119

    CAS  Google Scholar 

  137. Wright DG, Kirkpatrick CH, Gallin JI (1977) Effects of levamisole on normal and abnormal leukocyte locomotion. J Clin Invest 59: 941–950

    PubMed  CAS  Google Scholar 

  138. Wyre HW, Johnson WT (1978) Clinical syndrome of Chemotaxis defect, infections, and hyperimmunoglobulinemia E. Arch Dermatol 114: 74–77

    Google Scholar 

  139. Yegin O (1983) Chemotaxis in childhood. Pediatr Res 17: 183–187

    PubMed  CAS  Google Scholar 

  140. Zankovich R, Schell-Frederick E, Diehl V (1985) Chronisch granulomatöse Erkrankung und Job–Syndrom: Ein primärer Defekt der Phagozytenfunktion. Dtsch Ärztebl 82: 1257–1263

    Google Scholar 

  141. Belohradsky BH (1986) Primäre Immundefekte. Klinik Immunologie and Genetik. W. Kohlkammer Verlag, Stuttgart Mainz Köln Berlin

    Google Scholar 

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Author notes

  1. W. Kiess

    Present address: National Institutes of Health, Bethesda, Maryland, USA

Authors and Affiliations

  1. Abteilung für Antimikrobielle Therapie und Infektionsimmunologie, Kinderklinik der Universität im Dr. von Haunerschen Kinderspital, Lindwurmstr. 4, 8000, München 2, Germany

    Prof. Dr. Bernd H. Belohradsky & S. Däumling

  2. Département de Pédiatrie, INSERM u-132, Hôpital Necker — Enfants Malades, 149 rue de Sèvres, Paris, France

    C. Griscelli

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  1. Prof. Dr. Bernd H. Belohradsky
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  2. S. Däumling
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  3. W. Kiess
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  4. C. Griscelli
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P. Frick G.-A. von Harnack K. Kochsiek G. A. Martini A. Prader

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Professor Dr. Walter H. Hitzig in Verehrung gewidmet

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Belohradsky, B.H., Däumling, S., Kiess, W., Griscelli, C. (1987). Das Hyper-IgE-Syndrom (Buckley- oder Hiob-Syndrom). In: Frick, P., von Harnack, GA., Kochsiek, K., Martini, G.A., Prader, A. (eds) Ergebnisse der Inneren Medizin und Kinderheilkunde/Advances in Internal Medicine and Pediatrics. Ergebnisse der Inneren Medizin und Kinderheilkunde/Advances in Internal Medicine and Pediatrics, vol 55. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71052-0_1

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