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Mammakarzinome. Neue Perspektiven experimenteller und klinischer Therapieforschung pp 44–50Cite as

Onkogene und Mammakarzinome

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Zusammenfassung

Die Fortschritte, die durch die Anwendung molekularbiologischer, virologischer und zellbiologischer Methoden in der Krebsforschung während der letzten Jahre erzielt wurden, weisen immer eindeutiger darauf hin, daß Krebs seine Ursache in der Mutation zellulärer Gene hat. Die genetischen Veränderungen aufzuklären, die der Krebsentstehung zugrunde liegen, die verantwortlichen Gene zu identifizieren und zu charakterisieren sind die Aufgaben, die sich die Onkogenforschung gestellt hat [24]. Der eigentliche Fortschritt, der schon erzielt wurde, besteht darin, daß der ungeheuer komplexe Phänotyp der transformierten Zellen auf die Aktivität individueller Gene und Genprodukte zurückgeführt werden konnte. Diese Gene, die die Hierarchie der Merkmale der transformierten Zellen beherrschen, also die zelluläre Genaktivität in Richtung Transformation drängen können, werden als Onkogene bezeichnet [1]. Die molekulare Klonierung und Aufschluß über die Wirkungsweise der Onkogenprodukte berechtigt zur Hoffnung, daß der Mechanismus der zellulären Transformation verstanden werden kann, ohne daß die Analyse jedes einzelnen beteiligten zellulären Gens vorausgesetzt werden muß [25].

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Authors
  1. S. Kozma
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  2. N. E. Hynes
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  3. K. Buser
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  4. R. Jaggi
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  5. B. Groner
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Editor information

Editors and Affiliations

  1. Abteilung Hämatologie/Onkologie, Medizinische Universitätsklinik, Robert-Koch-Straße 40, D-4300, Göttingen, Deutschland

    G. A. Nagel

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© 1986 Springer-Verlag Berlin Heidelberg

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Kozma, S., Hynes, N.E., Buser, K., Jaggi, R., Groner, B. (1986). Onkogene und Mammakarzinome. In: Nagel, G.A. (eds) Mammakarzinome. Neue Perspektiven experimenteller und klinischer Therapieforschung. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71041-4_5

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  • DOI: https://doi.org/10.1007/978-3-642-71041-4_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71042-1

  • Online ISBN: 978-3-642-71041-4

  • eBook Packages: Springer Book Archive

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