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Cyclosporine: Chemistry, Structure-Activity Relationships and Mode of Action

Conference paper
Part of the Progress in Clinical Biochemistry and Medicine book series (PCBM, volume 3)

Abstract

Cyclosporine is a cyclic peptide with a selective immunosuppressive action. One of its 11 amino acids is a novel amino acid, (4R)-4-((E)-2-butenyl-4,N-dimethyl-L-threonine, the preparation of which allowed the synthesis of cyclosporine and specifically modified analogues. Structure-activity relationships emerging from the study of modified cyclosporins suggest that a large portion of the cyclosporine molecule is involved in interactions with its lymphocyte receptor and that this includes amino acids 1, 2, 3 and 11.

Keywords

Phorbol Myristate Acetate Tolypocladium Inflatum Peptide Ring Hydroxy Aldehyde Cyclosporine Analogue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  1. 1.Preclinical ResearchSandoz LtdBaselSwitzerland

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