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Genetic Control of the Susceptibility to Pneumococcal Infection

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Genetic Control of the Susceptibility to Bacterial Infection

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 124))

Abstract

As with other pathogens used to infect mice, it has been known for some time that mouse strains differ in their ability to be infected by Streptococcus pneumoniae (Webster 1933; Schultz et al. 1936; Rake 1936). These observations provide evidence that there are genetic differences in mice that affect their resistance to pneumococci. Some of the earliest studies of genetic differences in pathogenesis of S. pneumoniae infections were done with the BS and BR mice which were bred by Lesslie Webster to be susceptible or resistant to infection with Salmonella enteritidis (Webster 1933). When Webster infected these mice with pneumococci by the nasal route, he found that BS mice were more susceptible to pneumococcal infection than the BR mice (Webster 1933).

This work has been supported by NIH grants CA 16673, CA 13148, AI 15986, AI 18557, and AI 21548 and Alabama Research Institute grant 420. David E. Briles is the recipient of a Research Career Development Award, AI 00498.

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Author information

Authors and Affiliations

  1. Department of Microbiology, Cellular Immunobiology Unit of the Tumor Institute, USA

    D. E. Briles, J. Horowitz, L. S. McDaniel, W. H. Benjamin Jr., C. L. Booker, G. Scott & C. Forman

  2. Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, 35294, USA

    D. E. Briles, J. Horowitz, L. S. McDaniel, W. H. Benjamin Jr., C. L. Booker, G. Scott & C. Forman

  3. Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, 48109, USA

    J. L. Claflin

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  1. D. E. Briles
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  2. J. Horowitz
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  3. L. S. McDaniel
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  4. W. H. Benjamin Jr.
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  5. J. L. Claflin
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  6. C. L. Booker
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  7. G. Scott
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Editors and Affiliations

  1. Department of Microbiology and Pediatrics, Cellular Immunobiology Unit of the Tumor Institute, USA

    David E. Briles Ph.D.

  2. Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, 35294, USA

    David E. Briles Ph.D.

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© 1986 Springer-Verlag Berlin · Heidelberg

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Briles, D.E. et al. (1986). Genetic Control of the Susceptibility to Pneumococcal Infection. In: Briles, D.E. (eds) Genetic Control of the Susceptibility to Bacterial Infection. Current Topics in Microbiology and Immunology, vol 124. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70986-9_7

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  • DOI: https://doi.org/10.1007/978-3-642-70986-9_7

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