Genetic Approaches to the Study of Disease Resistance: With Special Emphasis on the Use of Recombinant Inbred Mice
Central to studies of microbial pathogenesis is an identification of the protective mechanisms that defend the host against each pathogen. One way to do this is to identify genes of the host that affect the resistance to the pathogen and then determine their mechanisms of action. This approach automatically establishes the in vivo relevance of all mechanisms studied. the discovery of variant alleles affecting particular functions also serves to identify important protective mechanisms that might have otherwise remained unknown. The power of this type of approach is aptly illustrated by the major histocompatibility complex of mammals and birds, where much of our present knowledge has come from attempts to understand how a single genetic region could affect graft rejection, immunoresponsiveness, and disease susceptibility.
KeywordsDisease Resistance Recombinant Inbred Congenic Strain Inbred Mouse Strain Parental Allele
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- Bailey DW (1981) Recombinant inbred strains and bilineal congenic strains. In: Fuster HL, Small JD, Fox JG (eds) The mouse in biomedical research, vol 1. Academic, New York, pp 224–239Google Scholar
- Baker PJ, Amsbaugh DF, Prescott B, Stashak PW, Rudbach JA (1978) Multigenic control of the antibody response to type III pneumococcal polysaccharide and other helper T cell independent antigens. In: Friedman H, Linna TJ, Prier JE (eds) Infection immunity and genetics. University Park Press, Baltimore, pp 67–84Google Scholar
- Benjamin W, Turnbough C, Posey B, Briles DE (1986) Salmonella typhimurium virulence genes necessary to exploit the Ity s / s genotype of the mouse. Infect Immun 51 (3)Google Scholar
- Biozzi G, Stiffel C, Mouton D, Bouthillier Y (1975) Selection of lines of mice with high and low antibody responses to complex immunogens. In: Benacerraf B (ed) Immunogenetics and immunodeficiency. University Park Press, Baltimore, pp 180–227Google Scholar
- Goldstein A (1964) Biostatistics: an introductory text. MacMillan, New York, pp 55–59Google Scholar
- Greenhouse DD (1984) Holders of inbred and mutant mice in the United States. National Academy, WashingtonGoogle Scholar
- McCarthy MM, Dutton RW (1975) The humoral response of mouse spleen cells to two types of sheep erythrocytes. I. Genetic control of the response to H and L SRBC. J Immunol 115: 1316–1321Google Scholar
- Rihova-Skarova B, Riha I (1974) Genetic regulation of the immune response to haptens. Ann Immunol (Paris) 125C: 195–198Google Scholar
- Snyder LH, David PR (1957) The principles of heredity. Heath, Boston, pp 197–210Google Scholar
- Svanborg Eden C, Briles DE, Hagberg L, Michalek SM, McGhee JR (1985) Susceptibility to Escherichia coli urinary tract infection linked to the Lps d gene. J Immunol (to be published)Google Scholar
- Wright S (1968) Evolution and genetics of populations, vol I. Genetic and biometric foundations. University of Chicago Press, Chicago, pp 372–420Google Scholar