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Genetic Approaches to the Study of Disease Resistance: With Special Emphasis on the Use of Recombinant Inbred Mice

  • D. E. Briles
  • W. H. BenjaminJr.
  • W. J. Huster
  • B. Posey
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 124)

Abstract

Central to studies of microbial pathogenesis is an identification of the protective mechanisms that defend the host against each pathogen. One way to do this is to identify genes of the host that affect the resistance to the pathogen and then determine their mechanisms of action. This approach automatically establishes the in vivo relevance of all mechanisms studied. the discovery of variant alleles affecting particular functions also serves to identify important protective mechanisms that might have otherwise remained unknown. The power of this type of approach is aptly illustrated by the major histocompatibility complex of mammals and birds, where much of our present knowledge has come from attempts to understand how a single genetic region could affect graft rejection, immunoresponsiveness, and disease susceptibility.

Keywords

Disease Resistance Recombinant Inbred Congenic Strain Inbred Mouse Strain Parental Allele 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • D. E. Briles
    • 1
    • 2
  • W. H. BenjaminJr.
    • 1
    • 2
  • W. J. Huster
    • 2
    • 3
  • B. Posey
    • 1
    • 2
  1. 1.Department of MicrobiologyCellular Immunobiology Unit of the Tumor InstituteUSA
  2. 2.Comprehensive Cancer CenterUniversity of Alabama at BirminghamBirminghamUSA
  3. 3.Department of Biomathematics and BiostatisticsCellular Immunobiology Unit of the Tumor InstituteUSA

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