Ontogeny of Sympathetic Nerves and Transport Functions in the Rabbit Choroid Plexus
The choroid plexus is responsible for the major part of the cerebrospinal fluid (CSF) formation and transport exchange between the CSF compartment and blood in the mammalian brain. The sympathetic nervous system is one regulator of CSF production in the rabbit (Lindvall et al. 1978, 1979) and influences choroid plexus transport mechanisms for weak organic bases in vitro (Lindvall et al. 1981). These effects seem to be mediated via 0-receptors in the choroid plexus epithelium (Lindvall et al. 1979, 1985a, Nathanson 1979). Na+-K+-ATPase is closely related to transport processes, across biological membranes, and a substantial activity of ouabain-sensitive Na+-K+-ATPase is found in the mammalian choroid plexus (Bonting et al. 1961, Vates et al. 1964, Lindvall et al. 1982, 1985b, Miwa et al. 1982, Mitchell et al. 1982). The sympathetic nerves of the choroid plexus have been found to modify the activity of this enzyme (Lindvall et al. 1981, 1982) in accordance with their effects on CSF production and active transport in vitro.
KeywordsChoroid Plexus Fourth Ventricle Post Partum Adrenergic Nerve Postnatal Development
Unable to display preview. Download preview PDF.
- Lindvall M, Owman Ch (1978) Early development of noradrenaline-containing sympathetic nerves in the choroid plexus system of the rabbit. Cell Tiss Res 192: 195 - 203Google Scholar
- Lindvall M, Owman Ch, Winbladh B (1982) Sympathetic influence on sodium-potassium activated adenosine triphosphatase activity of rabbit and rat choroid plexus. Brain Res Bull 9:757-760 Lindvall M, Owman Ch, Winbladh B ( 1985b ) Early postnatal development of transport functions in the rabbit choroid plexus. J Cereb Blood Flow Metab (In press)Google Scholar
- Mitchell W, Kim CS, O’Tuama LA, Pritchard JB, Pick JR (1982) Choroid plexus, brain and kidney Na+, K+-ATPase: Comparative activities in fetal, newborn and young adult rabbits. Neurosci Lett 31: 37–40Google Scholar
- Nathanson JA (1979) ~-Adrenergic-sensitive adenylate cyclase in secretory cells of the choroid plexus. Science 204:843–844Google Scholar
- Pershing LK, Johanson CE (1982) Acidosis-induced enhanced activity of the Na-K exchange pump in the in vivo choroid plexus: An ontogenetic analysis of possible role in cerebrospinal fluid pH homeostasis. J Neurochem 38: 322-332Google Scholar
- Tennyson V (1975) Ultrastructural characteristics of the telencephalic and myelencephalic choroid plexuses in fetus of man and rabbit, and a comparison with the adult choroid plexus in rabbit. In: Netsky MG, Shuangshoti S (eds) The choroid plexus in health and disease. Wright, Bristol, UK, p 36 - 71Google Scholar
- Tennyson VM, Pappas GD (1968) The fine structure of the choroid plexus: Adult and developmen¬tal stages. Progr Brain Res 29: 63-85Google Scholar