Ontogeny of Sympathetic Nerves and Transport Functions in the Rabbit Choroid Plexus
The choroid plexus is responsible for the major part of the cerebrospinal fluid (CSF) formation and transport exchange between the CSF compartment and blood in the mammalian brain. The sympathetic nervous system is one regulator of CSF production in the rabbit (Lindvall et al. 1978, 1979) and influences choroid plexus transport mechanisms for weak organic bases in vitro (Lindvall et al. 1981). These effects seem to be mediated via 0-receptors in the choroid plexus epithelium (Lindvall et al. 1979, 1985a, Nathanson 1979). Na+-K+-ATPase is closely related to transport processes, across biological membranes, and a substantial activity of ouabain-sensitive Na+-K+-ATPase is found in the mammalian choroid plexus (Bonting et al. 1961, Vates et al. 1964, Lindvall et al. 1982, 1985b, Miwa et al. 1982, Mitchell et al. 1982). The sympathetic nerves of the choroid plexus have been found to modify the activity of this enzyme (Lindvall et al. 1981, 1982) in accordance with their effects on CSF production and active transport in vitro.
KeywordsFormaldehyde Adenosine Polypeptide Noradrenaline Fluores
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