Regional Cerebral Protein Synthesis in Experimental Hydrocephalus
Hydrocephalic conditions have been studied extensively both in the clinic and in animal experiments. Most of these studies have dealt with the dynamics of cerebrospinal fluid and with the associated morphological and electrophysiological changes but little information is available on regional metabolic alterations. For this reason regional protein synthesis was investigated in Kaolin-induced hydrocephalus in the rat. This model was first described by Dixon & Heller in 1932 and has since been utilized as one of the most reliable procedures for experimental induction of hydrocephalus. Protein synthesis was examined both in acute and chronic stages of hydrocephalus by autoradiography using 14-C labeled amino acids.
KeywordsChronic Stage Obstructive Hydrocephalus Label Amino Acid Potassium Chloride Solution Amino Acid Incorporation
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