Intracranial Volume Load Tolerance
In 1970 we reported an experimental study on cats, in which expansion of an epidural balloon in the supratentorial space at constant rates in the range of 0.017 to 1.00 ml per min led to a respiratory arrest at the same balloon volume (about 11% of the intracranial volume) irrespective of the rate of expansion. Our findings were in part confirmed later by Nakatani and Ommaya (1972) and by Zidan and Girvin (1978). Our study has recently been expanded in order to test this model in quantitative evaluation of adversive agents and therapeutic measures.
KeywordsRespiratory Arrest Systemic Arterial Pressure Intracranial Volume Volume Tolerance Balloon Volume
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