The Vasodilatory Cascade and Intracranial Pressure
For several years, the concept that cerebral pressure autoregulation was absent in the face of significant CNS injury has been prominent. More recently evidence has been accumulating that while severe CNS injury of traumatic, neoplastic or other etiology may well partially impair such autoregulation, it still may remain grossly intact. Previous reports by this investigator suggest that CSF pressure waves are the reflection of a mostly intact and autoregulating cerebral vascular bed interacting with an unstable cerebral perfusion pressure (CPP) usually induced by subtle changes in systemic arterial blood pressure (SABP).
KeywordsCerebral Blood Volume Head Elevation Systemic Arterial Blood Pressure Plateau Wave Ischemic Response
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