The Effect of Dimethylsulfoxide (DMSO) on Intracranial Pressure and Outcome After Severe Head Injury
Despite aggressive surgical and intensive medical management of patients with severe head injury, uncontrolled ICP elevation still occurs with disappointing regularity and frequently is associated with death or severe disability. Anecdotal reports have suggested that elevated ICP in traumatic coma, unresponsive to induced barbiturate coma and other standard management regimens, can be lowered by intravenous administration of DMSO (Waller 1983; Marshall 1984). In an attempt to improve management of traumatic intracranial hypertension, we have conducted a prospective randomized controlled trial of DMSO compared to conventional therapy to assess its effects on ICP and outcome after severe head injury.
KeywordsToxicity Ischemia DMSO Creatinine Dimethyl
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