A Study of Potassium Canrenoate on Raised Intracranial Pressure and on the Metabolism of Electrolytes and Hormones
Several studies have demonstrated that potassium canrenoate (C-K), an aldosterone antagonist, reduces perifocal brain edema (1,2,3,4). The action of C-K on the central nervous system is probably not specific but due to an increase of aldosterone as a result of competitive blockade at its renal site of action by C-K. Little information is available as regards the effects of C-K on raised intracranial pressure (ICP). We have studied the effects of C-K on raised ICP and on the metabolism of electrolytes and hormones.
KeywordsEpinephrine Catecholamine Renin Aldosterone Antidiuretic Hormone
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