A Study of Potassium Canrenoate on Raised Intracranial Pressure and on the Metabolism of Electrolytes and Hormones
Several studies have demonstrated that potassium canrenoate (C-K), an aldosterone antagonist, reduces perifocal brain edema (1,2,3,4). The action of C-K on the central nervous system is probably not specific but due to an increase of aldosterone as a result of competitive blockade at its renal site of action by C-K. Little information is available as regards the effects of C-K on raised intracranial pressure (ICP). We have studied the effects of C-K on raised ICP and on the metabolism of electrolytes and hormones.
KeywordsIntracranial Pressure Brain Edema Cyclic Nucleotide Nippon Medical School Decrease Group
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- 2.Mansury L, Fischer G, Bret P, Ravon R (1970) Oedeme Cerebral et Hyperaldo-steronisme. Presse Med 78: 2431–2432Google Scholar
- 3.Revlen HJ, Hadjidimos A, Hase U (1973) Steroids in the treatment of brain edema. In: Advances in Neurosurgery I. Brain edema and cerebellar pontine angle tumor. Berlin, Springer-Verlag, p 9 2–99Google Scholar
- 4.Schmiedek P, Baethmann A, Achneider E, Brendel W, Enzenbach R, Marguth F (1972) Use of spironolactone in the treatment of cerebral edema in neurosurgical patients. In: Extrarenal activity of aldosterone and its antagonists. Amsterdam, Excerpta Medica, p 234–237Google Scholar