A Study of Potassium Canrenoate on Raised Intracranial Pressure and on the Metabolism of Electrolytes and Hormones

  • Y. Node
  • S. Nakazawa
  • K. Yajima
  • Y. Tsuji
  • T. Hasegawa
Conference paper

Abstract

Several studies have demonstrated that potassium canrenoate (C-K), an aldosterone antagonist, reduces perifocal brain edema (1,2,3,4). The action of C-K on the central nervous system is probably not specific but due to an increase of aldosterone as a result of competitive blockade at its renal site of action by C-K. Little information is available as regards the effects of C-K on raised intracranial pressure (ICP). We have studied the effects of C-K on raised ICP and on the metabolism of electrolytes and hormones.

Keywords

Epinephrine Catecholamine Renin Aldosterone Antidiuretic Hormone 

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References

  1. 1.
    Baethmann A, Brendel W, Koczorek Kh R, Enzenbach R (1970) Pathophysiologic des traumatischen Hirnodems. Dtsch Med Wschft 95: 1020–1024CrossRefGoogle Scholar
  2. 2.
    Mansury L, Fischer G, Bret P, Ravon R (1970) Oedeme Cerebral et Hyperaldo-steronisme. Presse Med 78: 2431–2432Google Scholar
  3. 3.
    Revlen HJ, Hadjidimos A, Hase U (1973) Steroids in the treatment of brain edema. In: Advances in Neurosurgery I. Brain edema and cerebellar pontine angle tumor. Berlin, Springer-Verlag, p 9 2–99Google Scholar
  4. 4.
    Schmiedek P, Baethmann A, Achneider E, Brendel W, Enzenbach R, Marguth F (1972) Use of spironolactone in the treatment of cerebral edema in neurosurgical patients. In: Extrarenal activity of aldosterone and its antagonists. Amsterdam, Excerpta Medica, p 234–237Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • Y. Node
    • 1
  • S. Nakazawa
    • 1
  • K. Yajima
    • 1
  • Y. Tsuji
    • 1
  • T. Hasegawa
    • 1
  1. 1.Department of NeurosurgeryNippon Medical SchoolTokyoJapan

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