Abstract
The parenchymal cells of the liver contain more than 90% of the total hepatic binding capacity for glycoproteins terminating in mannose or N-acetylglucosamine [1, 2]. It was thought that all of this binding capacity was intracellular; mannose-specific uptake of glycoproteins by hepatocytes was suspected [3, 4], but it was not definitely shown to occur until recently [5]. In order to obtain detailed evidence for the receptor-mediated endocytosis of mannose-terminated proteins in hepatocytes, we used a glycoprotein ligand with a high molecular weight: yeast invertase. It contains about 50% mannose by weight in several large polymannose chains which are attached to the peptide via two N-acetylglucosamine residues [6, 7].
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© 1986 Springer-Verlag Berlin Heidelberg
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Tolleshaug, H., Blomhoff, R., Blomhoff, H.K., Berg, T., Christensen, T.B. (1986). Receptor-Mediated Endocytosis of Mannose-Terminated Glycoproteins in Hepatocytes. In: Greten, H., Windler, E., Beisiegel, U. (eds) Receptor-Mediated Uptake in the Liver. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70956-2_28
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DOI: https://doi.org/10.1007/978-3-642-70956-2_28
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