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Turnover of Light and Heavy Fractions of Human LDL in Normal and WHHL Rabbits

  • M. Kano
  • J. Koizumi
  • A. Jadhav
  • G. R. Thompson
Conference paper

Abstract

In humans light (L) LDL is catabolised faster than heavy (H) LDL, of which it is the precursor (Thompson et al., 1982). In familial hypercholesterolaemia (FH) this relationship is lost and the catabolism of L-LDL is decreased more markedly than that of H-LDL. However, the catabolic defect, especially of L-LDL, can be partly reversed by therapeutic measures which stimulate LDL receptors. This suggests that catabolism of L-LDL is normally more dependent on LDL-receptor-mediated mechanisms than is catabolism of H-LDL (Thompson et al., 1984).

Keywords

Heavy Fraction Familial Hypercholesterolemia Familial Hypercholesterolaemia Fractional Catabolic Rate WHHL Rabbit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Spengel FA, Harders-Spengel K, Duffield R, Wood C, Myant NB, Thompson GR (1982) The effect of partial ileal bypass on receptor-mediated uptake and catabolism of low density lipoprotein in the Rhesus monkey. Res Exp Med 180: 263–270CrossRefGoogle Scholar
  2. 2.
    Teng B, Thompson GR, Sniderman AD, Forte TM, Krauss RM, Kwiterovich PO (1983) Composition and distribution of low density lipoprotein fractions in hyperapobetalipoprotei-nemia, normolipidemia and familial hypercholesterolemia. Proc Natl Acad Sci USA 80: 6662–6666PubMedCrossRefGoogle Scholar
  3. 3.
    Thompson GR, Soutar AK, Spengel FA, Jadhav A, Gavigan SJP, Myant NB (1981) Defects of receptor-mediated low densitiy lipoprotein catabolism in homozygous familial hypercholesterolemia and hypothyroidism in vivo. Proc Natl Acad Sci USA 78: 2591–2595PubMedCrossRefGoogle Scholar
  4. 4.
    Thompson GR, Teng B, Sniderman A (1982) Metabolic conversion of ‘light’ to ‘heavy’ low density lipoprotein (LDL) in subjects with normal and increased plasma LDL-apoB levels Circulation 66 Supp II, 158Google Scholar
  5. 5.
    Thompson GR, Teng B, Sniderman AD (1984) Preferential catabolism of light LDL by the receptor-mediated pathway Circulation 70 Supp II 268Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • M. Kano
    • 1
  • J. Koizumi
    • 1
  • A. Jadhav
    • 1
  • G. R. Thompson
    • 1
  1. 1.MRC Lipoprotein TeamHammersmith HospitalLondonEngland

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