Zusammenfassung
Lange vor der Entdeckung der Psychopharmaka erhoffte man durch die Erforschung hormoneller Vorgänge Grundlagen für die gesunde psychische Entwicklung zu finden. Der Schweizer Psychiater Manfred Bleuler definierte 1954 die Aufgaben dieses Forschungsgebietes, das er in Anlehnung an Laignel-Lavastine „endokrinologische Psychiatrie“nannte. Er verstand darunter die Lehre von den Zusammenhängen zwischen endokrinologischen und psychischen Krankheitserscheinungen. Besonders hervorzuheben ist, daß Bleuler die Hypothese überprüfen wollte, ob psychopathologi-sche und endokrinologische Auffälligkeiten verschiedene Seiten ein und desselben Lebensvorganges sind, oder ob sie sich gegenseitig beeinflussen. In engem Zusammenhang mit diesen ätiologisch ausgerichteten Fragen stand der Wunsch, die aus der endokrinologisch-psychiatrischen Forschung gewonnenen Erfahrungen klinisch umzusetzen. Man erwartete zu dieser Zeit Kenntnisse darüber zu erlangen, „ob und wie sich die Persönlichkeit und ihre Störungen durch das Endokrinium treffende Behandlungen beeinflussen lassen und umgekehrt“. Die Hypothese, vom Endokrinium aus die Psyche und von der Psyche aus das Endokrinium zu beeinflussen, erweckte große therapeutische Hoffnungen. Man glaubte bald, mit Hilfe von Hormontherapien manisch-depressive Patienten, Schizophrenie, Epilepsie, Neurosen, Psychopathien und andere psychische Erkrankungen heilen zu können. Auch hoffte man, die Reifung des Gesunden lenken und sein Altern verzögern zu können.
Einige der zitierten Arbeiten des Autors wurden durch die Unterstützung der Deutschen Forschungsgemeinschaft (Ho-940 1/1) ermöglicht.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
American Psychiatric Association (1980) Diagnostic and Statistic Manual of Mental Disorders (DSM-III), 3rd ed. American Psychiatric Association, Washington DC
Angst J, Dobler-Mikola A (1984) The Zurich Study. II. The continuum from normal to pathological depressive mood swings. Eur Arch Psychiat Neurol Sci 234: 21 – 29
Arana GW, Workman RJ, Baldessarini RJ (1984) Association between low plasma levels of dexamethasone and elevated levels of Cortisol in psychiatric patients given dexamethasone. Amer J Psychiat 141: 1619–1620
Asnis GM, Sachar EJ, Halbreich U, Nathan RS, Ostrow L, Halpern FS (1981) Cortisol secretion and dexamethasone response in depression. Amer J Psychiat 138: 1218 – 1221
Baldessarini R, Finklestein S, Arana GW (1983) The predictive power of diagnostic tests and the effect of prevalence of illness. Arch Psychiat 40: 569 – 573
Bardeleben U v, Holsboer F, Stalla GK, Müller OA (1985) Combined administration of human corticotropin-releasing factor and lysine vasopressin induces Cortisol escape from dexamethasone suppression in healthy subjects. Life Sciences 37:1613 – 1618
Bech P, Gjerris A, Anderson J (1983) The melancholia scale and the Newcastle scales: itemcombination and inter-observer reliability. Brit J Psychiat 143: 58 – 63
Beckmann H, Holzmüller B, Fleckenstein P (1984) Clinical investigations into antidepressive mechanisms. II. Dexamethasone suppression test predicts response to nomifensine or amitriptyline. Acta psychiat scand 70: 342 – 353
Berger M, Doerr P, Lund T, Bronisch T, Zerssen D v (1982) Neuroendocrinological and neurophysiological studies in major depressive disorders: Are there biological markers for the endogenous subtype? Biol Psychiat 17: 1217 – 1242
Berger M, Pirke KM, Doerr P, Krieg JC, Zerssen D v (1983) Influence of weight loss on the dexamethasone suppression test. Arch gen Psychiat 40: 585 – 586
Berger M, Pirke KM, Doerr P, Krieg JC, Zerssen D v (1984) The limited utility of the dexamethasone supression test for the diagnostic process in psychiatry. Brit J Psychiat 145: 372–382
Bleuler M (1954) I. Einleitung: Ziele, Grundlagen und Grenzen. In: Bleuler M (ed) Endokrinologische Psychiatrie. Thieme, Stuttgart, S 1–27
Britton DR, Koob GF, Rivier J, Vale W (1982) Intraventricular corticotropin-releasing factor enhances behavioral effects of novelty. Life Sci 31: 363 – 367
Brown WA, Johnston R, Mayfield D (1979) The 24-hour dexamethasone suppression test in a clinical setting: relationship to diagnosis, symptoms and response to treatment. Amer J Psychiat 136:543–547
Brown WA (1980) Dexamethasone suppression test identifies subtypes of depression which respond to different antidepressant. Lancet I: 928 – 929
Cantwell DP, Sturzenberger S, Burroughs J, Salkin B, Green JK (1977) Anorexia nervosa, an affective disorder? Arch gen Psychiat 34: 1037–1093
Carroll, BJ (to be published) Dexamethasone suppression test: a review of contemporary confusion. J Clin Psychiat
Carroll BJ, Schroeder K, Mukhodpadhyay S et al. (1980) Plasma dexamethasone concentrations and Cortisol suppression response in patients with endogenous depression. J Clin Endocrinol Metab 51: 433–437
Carroll BJ, Feinberg M, Greden JF et al. (1981) A specific laboratory test for the diagnosis of melancholia. Arch gen Psychiat 38: 15 – 22
Checkley SA (1980) Neuroendocrine tests of monoamine function in man: a review of basic theory and its application to the study of depressive illness. Psychol Med 10: 35 – 53
Dewan MJ, Pandurangi AK, Boucher ML, Levy BF, Major LF (1982) Abnormal dexamethasone suppression test results in chronic schizophrenic patients. Amer J Psychiat 139:1501–1503
Evans DL, Nemeroff CB (1984) Clinical use of the dexamethasone suppression test in DSM III affective disorders. Arch gen Psychiat, submitted
Extein I, Pottash ALC, Gold MS (1981) Relationship to thyrotropin-releasing hormone test and dexamethasone suppression test abnormalities in unipolar depression. Psychiat Res 4:49 – 53
Extein I, Pottash ALC, Gold MS, Cowdry RW (1982) Using the protirelin test to distinguish mania from schizophrenia. Arch gen Psychiat 39: 77 – 81
Galen RS (1983) The predictive value of laboratory diagnoses. Bull Mol Biol Med 8:159–169
Georgotas A, Stokes PE, Krakowski M, Fanelli C, Cooper T (1984) Hypothalamic-pituitary-adrenocortical function in geriatric depression: diagnostic and treatment implications. Biol Psychiat 19:685–693
Gerken A, Holsboer F (1985) Cortisol and corticosterone response after syncorticotropin in relationship to dexamethasone suppressibility of Cortisol. Psychoneuroendocrinol
Gerken A, Maier W, Holsboer F (to be published) Weekly monitoring of dexamethasone suppression response in depression: its relationship to change of body weight and psychopathology. Psychoneuroendocrinol 10:261–271
Gold MS, Pottasch ALC, Ryan N, Sweeney DR, Davies RK, Martin DM (1980) TRH-induced TSH response in unipolar bipolar and secondary depressions: possible utility in clinical assessment and differential diagnosis. Psychoneuroendocrinol 5: 144–155
Greden JF, Gardner R, King D, Grunhaus L, Kronfol Z, Carroll BJ (1983) Dexamethasone suppression tests in antidepressant treatment of melancholia. The process of normalization and test-retest reproducibility. Arch gen Psychiat 40: 493 – 500
Heimann H (1979) Klinische und psychopathologische Grundlagen. In: Kisker KP, Meyer JE, Müller C, Strömgren E (eds) Psychiatrie der Gegenwart, Forschung und Praxis, Grundlagen und Methoden der Psychiatrie, Teil 1. Springer, Berlin Heidelberg New York, S 2–42
Holsboer F, Bender W, Benkert O, Klein HE, Schmauss M (1980) Diagnostic value of dexamethasone suppression test in depression. Lancet I: 706
Holsboer F, Liebl R, Hofschuster E (1982a) Repeated dexamethasone suppression test during depressive illness. Normalization of the test result compared with clinical improvement. J Affect Dis 4: 93–101
Holsboer F, Winter K, Doerr HG, Sippell WG (1982b) Dexamethasone suppression test in female patients with endogenous depression: determination of plasma corticosterone, 11-deoxycorticosterone, 11-deoxycortisol, Cortisol and cortisone. Psychoneuroendocrinol 7: 329–338
Holsboer F, Doerr HG, Sippell WG (1982c) Dexamethasone suppression of 11-deoxycorticosterone, corticosterone, and Cortisol in depressed female patients and normal controls. Acta psychiat scand 66: 18 – 25
Holsboer F (1983) Prediction of clinical course by dexamethasone suppression test (DST) response in depressed patients — physiological and clinical construct validity of the DST —. Pharmacopsychiat 16: 186–191
Holsboer F, Steiger A, Maier W (1983a) Four cases of reversion to abnormal dexamethasone suppression test response as indicator of clinical relapse: a preliminary report. Biol Psychiat 18: 911–916
Holsboer F, Doerr HG, Sippell WG (1983b) Increased sensitivity of the dexamethasone suppression test in depressed female patients based on multisteroid analysis. Psychiat Res 8: 49–57
Holsboer F, Gerken A, Steiger A, Fass V (1984a) The mean 14.00h— 17.00h plasma Cortisol concentration and its relationship to the 1 mg dexamethasone suppression response in depressives and controls. Acta psychiat scand 69: 383 – 390
Holsboer F, Haack D, Gerken A, Vecsei P (1984b) Plasma dexamethasone concentrations and differential glucocorticoid suppression response in depressives and controls. Biol Psychiat 19: 281–291
Holsboer F, Philipp M, Gerken A (1984c) Dexamethasone suppression test (DST) and weight loss. Psychiat Res 13: 353–354
Holsboer F, Müller OA, Doerr HG et al. (1984d) ACTH and multisteroid responses to corticotropin-releasing factor in depressive illness: relationship to multisteroid responses after ACTH stimulation and dexamethasone suppression. Psychoneuroendocrinol 9: 147 – 160
Holsboer F, Gerken A, Steiger A, Benkert O, Müller OA, Stalla GK (1984e) Corticotropin-releasing factor induced pituitary-adrenal response in depression. Lancet I: 55
Holsboer F, Bardeleben U v, Gerken A, Stalla GK, Müller OA (1984f) Blunted corticotropin and normal Cortisol response to human corticotropin releasing factor (h —CRF) in depression. New Engl J Med 311: 1127
Holsboer F (1985) Die Entwicklung endokrinologischer Tests in der Depressions-Forschung am Beispiel des Dexamethason-Suppressions-Test. In: Hippius H, Matussek N (Hrsg) Advances in Pharmacotherapy. S Karger AG, Basel (Differentialtherapie der Depression — Möglichkeiten und Grenzen, Vol II, pp 101 – 119)
Holsboer F, Benkert O (1985) Neuroendokrinologische und endokrinologische Forschung bei depressiven Patienten. Nervenarzt 56: 1 – 11
Holsboer F, Gerken A, Bardeleben U v, Grimm W, Stalla GK, Müller OA (1985a) Relationship between pituitary responses to human corticotropin-releasing factor and thyrotropin-releasing hormone in depressives and normal controls. Europ J Pharmacol 110: 153 – 154
Holsboer F, Wiedemann K, Gerken A, Boll E (to be published) The plasma dexamethasone variable in depression — test retest studies and early biophase kinetics. Psychiat Res
Johnson GF, Hunt G, Kerr K, Caterson I (1984) Dexamethasone suppression test (DST) and plasma dexamethasone levels in depressed patients. Psychiat Res 13: 305 – 313
Kendell RE (1976) The classification of depressions: a review of contemporary confusion. Brit J Psychiat 129: 15–28
King D, Dowdy S, Jack R, Gardner R, Edwards P (1982) the dexamethasone suppression test as a predictor of sleep deprivation antidepressant effect. Psychiat Res 7: 93 – 99
Laakmann G, Benkert O (1978) Neuroendokrinologie und Psychopharmaka. Arzneim Forsch/Drug Res 28: 1277–1280
Labrie F, Giguere V, Proulx L, Lefevre G (1984) Interactions between CRF epinephrine vasopressin and glucocorticoids in the control of ACTH secretion. J Steroid Biochem 20: 153–160
Langer G, Resch F, Aschauer H, Keshavan MS, Koinig G, Schönbeck G, Dittrich R (1984) TSH-response patterns to TRH stimulation may indicate therapeutic mechanisms of antidepressant and neuroleptic drugs. Neuropsychobiol 11: 213 – 218
Loosen PT, Prange AJ jr (1982) Serum thyrotropin response to thyrotropin-releasing hormone in psychiatric patients: a review. Amer J Psychiat 139: 405–416
Matussek N (1978) Neuroendokrinologische Untersuchungen bei depressiven Syndromen. Nervenarzt 49: 569–575
Mezey E, Kiss JZ, Skirboll LR, Goldstein M, Axelrod J (1984) Increase of corticotropinreleasing factor staining in rat paraventricular nucleus neurones by depletion of hypothalamic adrenaline. Nature 310: 140–141
Morley JE (1981) Neuroendocrine control of thyrotropin secretion. Endocrine Reviews 2: 396–436
Nasrallah HA, Coryell WH (1982) Dexamethasone nonsuppression predicts the antidepressant effects of sleep deprivation. Psychiat Res 6: 61 – 64
Peselow ED, Goldring N, Fieve RR, Wright R (1983) The dexamethasone suppression test in depressed outpatients and normal control subjects. Amer J Psychiat 140: 245 – 247
Philipp M, Maier W, Holsboer F (to be published) Psychopathological correlates of plasma Cortisol after dexamethasone suppression: a polydiagnostic approach. Psychoneuroendocrinol
Re RE, Kourides IA, Ridway EC, Weintraub BD, Maloof F (1976) The effect of glucocorticoid administration on human pituitary secretion of thyrotropin and prolactin. J Clin Endocrinol Metab 43: 338–346
Rubin RT, Poland RE, Blodgett ALN, Winston RA, Forster B, Carroll BJ (1980) Cortisol dynamics and dexamethasone pharmacokinetics in primary endogenous depression: preliminary findings. Progr in Psychoneuroendocrinol: 223 – 234
Rush J, Giles DE, Roffwarg HP, Parker CR (1982) Sleep EEG and dexamethasone suppression test findings in outpatients with unipolar major depressive illness. Biol Psychiat 17: 327 – 341
Sachar EJ (1975) Neuroendocrine abnormalities in depressive illness. In: Sachar EJ (ed) Topics in psychoneuroendocrinology. Grune & Stratton, New York San Francisco London, p 135–156
Sachar, EJ, (1978) Neuroendocrine responses to psychotropic drugs. In: Lipton MA, DiMascio A, Killam KF (eds) Psychopharmacology: a generation of progress. Raven Press, New York, p 499–507
Stokes PE, Stoll PM, Koslow SH, Maas JW, Davis JM, Swann AC, Robins E (1984) Pretreatment DSt and hypothalamic-pituitary-adrenocortical function in depressed patients and comparison groups. Arch Gen Psychiat 41: 257 – 267
Sutton RE, Koob GF, Le Moal M, Rivier J, Vale W (1982) Corticotropin releasing factor produces behavioral activation in rats. Nature 297: 331 – 333
Swanson LW, Sawchenko PE, Rivier J, Vale W (1983) Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: an immunohistochemical study. Neuroendocrinol 36: 165 – 186
Thomas EB, Levine S, Arnold WJ (1968) Effects of maternal deprivation and incubations rearing upon adrenocortical activity in the adult rat. Develop Psychobiol 1: 21–23
Trachsler E, Höchli D, Luckner N v, Woggon B (1985) Dexamethasone suppression test before and after partial sleep deprivation in depressed schizophenic and schizoaffective patients. Pharmacopsychiat 18: 110–111
Valentino RJ, Foote SL, Aston-Jones G (1983) Corticotropin-releasing factor activates noradrenergic neurons of the locus coeruleus. Brain Res 270: 363 – 367
Waldmeier PC, Baumann PA, Hauser K, Maitre L, Storni A (1982) Oxaprotiline, a noradrenaline uptake inhibitor with an active and an inactive enantiomer. Biochem Pharmacol 31:2169–2176
Wilens TE, Ritchie JC, Carroll BJ (1984) Comparison of plasma Cortisol and corticosterone in the dexamethasone suppression test for melancholia. Psychoneuroendocrinol 9: 45 – 55
Winokur A, Caroff SN, Amsterdam JD, Maislin G (1984) Administration of thyrotropin-releasing hormone at weekly intervals results in a diminished thyrotropin response. Biol Psychiat 5: 695–702
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Holsboer, F. (1986). Klinischer Nutzen psychoneuroendokrinologischer Untersuchungen. In: Heimann, H., Gaertner, H.J. (eds) Das Verhältnis der Psychiatrie zu ihren Nachbardisziplinen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70952-4_7
Download citation
DOI: https://doi.org/10.1007/978-3-642-70952-4_7
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-16179-0
Online ISBN: 978-3-642-70952-4
eBook Packages: Springer Book Archive