Iodoazomycin Riboside [l-(5′-iodo-5′- deoxyribofuranosyl)-2-nitroimidazolel, a Hypoxic Cell Marker In Vivo Evaluation in Experimental Tumors

  • L. I. Wiebe
  • D. C. Jette
  • J. D. Chapman
  • R. J. Flanagan
  • B. E. Meeker


Radiosensitizers labelled with nuclides which emit gamma rays have been proposed to have clinical value in the detection of radioresistant hypoxic cell populations in tumors [1]. Such a diagnostic procedure would be of value for radiation and/or chemotherapy treatment planning in oncology, and could aid the study and treatment of ischemic tissue in the myocardium and in the brain. However, the sensitizers 4-[82Br]-bromomisonidazole (BrMISO) [2] and l-[2-(2-[131I]iodophenoxy)-ethyl]-2-nitroimidazole (IPENI) [3] failed to undergo selective uptake in experimental tumor models. In both cases, and especially with IPENI, the test substances were more lipophilic than hypoxic cell markers used previously [4]. Recent efforts with tritiated misonidazole to label hypoxic cell fractions in human tumors have provided clinical data which support the concept that hypoxic cells may be detected by scintigraphic methods [5].


Sugar HPLC Ethyl Adenocarcinoma Iodine 


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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • L. I. Wiebe
    • 1
  • D. C. Jette
  • J. D. Chapman
  • R. J. Flanagan
  • B. E. Meeker
  1. 1.Faculty of Pharmacy and Pharmaceutical SciencesUniversity of AlbertaEdmontonCanada

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