Skip to main content
SpringerLink
Log in

Uptake of 11C-Aminocyclopentane Carboxylic Acid (ACPC) and 13N-Ammonia in Malignant Tumors A Comparative Clinical Study

  • Conference paper
Book cover Nuclear Medicine in Clinical Oncology

Abstract

Positron emission tomography (PET) can be used advantageously in oncological patients to study the in vivo biochemical properties in tumors and to monitor their metabolic response to therapy [1]. Among the potential agents which are available for this purpose are 11C-aminocyclopentane carboxylic acid or ACPC (a non-metabolized amino acid) and 13N-ammonia, both of which show tumor affinity in humans [2-5].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Beaney RP (1984) Positron emission tomography in the study of human tumors. Semin Nucl Med 14:324–341

    Article  PubMed  CAS  Google Scholar 

  2. Hubner KF, Andrews GA, Washburn L, et al. (1977) Tumor location with 1-amino- cyclopentane (11C) carboxylic acid: preliminary clinical trials with single-photon detection. J Nucl Med 18:1215–1221

    PubMed  CAS  Google Scholar 

  3. Hübner KF, Strauss S, Washburn LC, et al. (1981) Tumor detection with 1-amino- cyclopentane and 1-aminocyclopentane C-11-carboxylic acid using positron emission computerized tomography. Clin Nucl Med 6:249–252

    Article  PubMed  Google Scholar 

  4. Schelstraete K, Simons M, Deman J, et al. (1982) Uptake of 13N-ammonia by human tumours as studied by positron emission tomography. Br J Radiol 55:797–804

    Article  PubMed  CAS  Google Scholar 

  5. Schelstraete K, Deman J, Vermeulen FL, et al. (1985) Kinetics of 13N-ammonia incorporation in human tumours. Nucl Med Comm 6:461–470

    Article  CAS  Google Scholar 

  6. Phelps ME, Hoffman EJ, Huang S-C, et al. (1976) Tomographic images of blood pool and perfusion in brain and heart. J Nucl Med 17:603–612

    PubMed  CAS  Google Scholar 

  7. Berlinguet L, Bégin N, Babineau LM (1962) Autoradiographic studies of distribution of 1-aminocyclopentane carboxylic acid in normal and cancerous mice. Can J Biochem 40:1111–1114

    Article  PubMed  CAS  Google Scholar 

  8. Sterling WR, Henderson JF, Mandel HG, et al. (1962) The metabolism of 1-amino- cyclopentane-carboxylic acid in normal and neoplastic tissues. Biochem Pharmacol 11:135–145

    Article  PubMed  CAS  Google Scholar 

  9. Siegers G, Vandecasteele C, Sambre J (1980) Cyclotron production of 13N-labelled ammonia for medical use. J Radioanal Chem 59:585–587

    Article  Google Scholar 

  10. Sambre J, Vandecasteele C, Goethals P, et al. (1985) Routine production of H11CN and (11C)-1-aminocyclopentane carboxylic acid. Int J Appl Radiot Isot 36:275–278

    Article  CAS  Google Scholar 

  11. Reiman RE, Huvos AG, Benua RS, et al. (1981) Quotient imaging with N-13 1-Glutamate in osteogenic sarcoma: correlation with tumor viability. Cancer 48:1976–1981

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiotherapy and Nuclear Medicine, University Hospital, De Pintelaan 185, B-9000, Gent, Belgium

    K. Schelstraete

Authors
  1. K. Schelstraete
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. De Vis
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. F. L. Vermeulen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. Deman
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J. Sambre
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. P. Goethals
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. D. Van Haver
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. G. Slegers
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. C. Vandecasteele
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. A. De Schryver
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institute for Clinical and Experimental Nuclear Medicine, University of Bonn, Sigmund-Freud-Str. 25, D-5300, Bonn-Venusberg, Germany

    Cuno Winkler M.D., Ph.D. (hon.) (Professor of Nuclear Medicine) (Professor of Nuclear Medicine)

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Schelstraete, K. et al. (1986). Uptake of 11C-Aminocyclopentane Carboxylic Acid (ACPC) and 13N-Ammonia in Malignant Tumors A Comparative Clinical Study. In: Winkler, C. (eds) Nuclear Medicine in Clinical Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70947-0_36

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-70947-0_36

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-16164-6

  • Online ISBN: 978-3-642-70947-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation