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Immunoscintigraphy of Gynaecological Tumors

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Nuclear Medicine in Clinical Oncology

Abstract

Neoplasms of the female genital tract present as a wide range of abnormalities and are the second most common source of fatal cancer in women after carcinoma of the breast [7]. Because of the diversity of gynaecological tumors, the diagnosis and followup of patients remains an important clinical problem. The application of techniques for early detection and successful treatment offers great prospects for the relief of suffering and extension of life. The targeting of monoclonal antibodies to tumors offers potential for both diagnosis and therapy and will hopefully improve the management of these patients.

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References

  1. Armitage NC, Perkins AC, Pimm MV, Farrands PA, Baldwin RW, Hardcastle JD (1984) The localisation of an anti-tumour monoclonal antibody (791T/36) in gastrointestinal tumours. Br J Surg 71:407–412

    Article  PubMed  CAS  Google Scholar 

  2. Armitage NC, Perkins AC, Pimm MV, Wastie ML, Baldwin RW, Hardcastle JD (1985) Imaging of primary and metastatic colorectal cancer using an 111In-labelled antitumour monoclonal antibody 791T/36. Nucl Med Commun (In press)

    Google Scholar 

  3. Epenetos AA, Mather S, Granowska M, Nimmon CC, Hawkins LR, Britton KE, Shepherd J, Taylor-Papadimitriou J, Durbin H, Malpas JS, Bodmer WF (1982) Targeting of iodine- 123-labelled tumour associated monoclonal antibodies to ovarian, breast and gastrointestinal tumours. Lancet 2:999–1004

    Article  PubMed  CAS  Google Scholar 

  4. Farrands PA, Perkins AC, Pimm MV, Hardy JG, Embleton MJ, Baldwin RW, Hardcastle JD (1982) Radioimmunodetection of human colorectal cancers by an anti-tumour monoclonal antibody. Lancet 2:396–400

    Google Scholar 

  5. Farrands PA, Perkins AC, Sulley L, Hopkins JS, Pimm MV, Baldwin RW, Hardcastle JD (1983) Localization of human osteosarcoma by anti-tumour monoclonal antibody 79IT/ 36. J Joint and Bone Surg 65-B:638–640

    Google Scholar 

  6. Goldenberg DM, DeLand FH (1982) History and status of tumour imaging with radiolabelled antibodies. J Biol Response Mod 1:121–136

    Google Scholar 

  7. Kraus FT (1977) Female genitalia. In: Anderson WAD, Kissane JM (eds) Pathology, vol 2. Mosby, St Louis

    Google Scholar 

  8. Mach J-P, Buchegger F, Forni M, Ritschard J, Berche C, Lumbroso J-D, Schreyer M, Giraroet C, Accolla RS, Carrel S (1981) Use of radiolabelled monoclonal anti-CEA antibodies for the detection of human carcinomas by external photoscanning and tomoscintigraphy. Immunol Today 2:239–249

    Article  Google Scholar 

  9. Perkins AC, Whalley DR, Hardy JG (1984) Physical approach for the reduction of dual radionuclide image subtraction artefacts in immunoscintigraphy. Nucl Med Commun 5:501–512

    Article  PubMed  CAS  Google Scholar 

  10. Perkins AC, Pimm MV, Birch MK (1985) The preparation and characterisation of 111Inlabelled 791T/36 monoclonal antibody for tumour immunoscintigraphy. Eur J Nucl Med 10:296–301

    Article  PubMed  CAS  Google Scholar 

  11. Pimm MV, Embleton MJ, Perkins AC, Price HR, Robins RA, Robinson GR, Baldwin RW (1982) In vivo localisation of antiosteogenic sarcoma 79IT monoclonal antibody in osteogenic sarcoma xenografts. Int J Cancer 30:75–85

    Article  PubMed  CAS  Google Scholar 

  12. Symonds EM, Perkins AC, Pimm MV, Baldwin RW, Hardy JG, Williams DA (1985) Clinical implications for immunoscintigraphy in patients with ovarian malignancy: a preliminary study using monoclonal antibody 791T/36. Br J Obstet Gynecol 92:270–276

    Article  CAS  Google Scholar 

  13. Williams MR, Perkins AC, Campbell FC, Pimm MV, Hardy JG, Wastie ML, Blamey RW, Baldwin RW (1984) The use of monoclonal antibody 791T/36 in the immunoscintigraphy of primary and metastatic carcinoma of the breast. Clin Oncol 10:375–381

    PubMed  CAS  Google Scholar 

  14. Witesbky E (1929) Disponibilität und Spezifítät alkohollöslicher Strukturen von Organen und bösartigen Geschwülsten. Z Immunitaetsforsch 62:35–73

    Google Scholar 

  15. Pimm MV, Perkins AC, Armitage NC, Baldwin RW (1985) The production of antimouse- IgG antibodies in patients receiving labelled monoclonal antibody for diagnostic immunoscintigraphy. J Nucl Med 26:1011–1023

    PubMed  CAS  Google Scholar 

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© 1986 Springer-Verlag Berlin Heidelberg

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Perkins, A.C., Powell, M.C., Pimm, M.V., Wastie, M.L., Symonds, E.M., Baldwin, R.W. (1986). Immunoscintigraphy of Gynaecological Tumors. In: Winkler, C. (eds) Nuclear Medicine in Clinical Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70947-0_27

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  • DOI: https://doi.org/10.1007/978-3-642-70947-0_27

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-16164-6

  • Online ISBN: 978-3-642-70947-0

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