Abstract
Neoplasms of the female genital tract present as a wide range of abnormalities and are the second most common source of fatal cancer in women after carcinoma of the breast [7]. Because of the diversity of gynaecological tumors, the diagnosis and followup of patients remains an important clinical problem. The application of techniques for early detection and successful treatment offers great prospects for the relief of suffering and extension of life. The targeting of monoclonal antibodies to tumors offers potential for both diagnosis and therapy and will hopefully improve the management of these patients.
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Armitage NC, Perkins AC, Pimm MV, Farrands PA, Baldwin RW, Hardcastle JD (1984) The localisation of an anti-tumour monoclonal antibody (791T/36) in gastrointestinal tumours. Br J Surg 71:407–412
Armitage NC, Perkins AC, Pimm MV, Wastie ML, Baldwin RW, Hardcastle JD (1985) Imaging of primary and metastatic colorectal cancer using an 111In-labelled antitumour monoclonal antibody 791T/36. Nucl Med Commun (In press)
Epenetos AA, Mather S, Granowska M, Nimmon CC, Hawkins LR, Britton KE, Shepherd J, Taylor-Papadimitriou J, Durbin H, Malpas JS, Bodmer WF (1982) Targeting of iodine- 123-labelled tumour associated monoclonal antibodies to ovarian, breast and gastrointestinal tumours. Lancet 2:999–1004
Farrands PA, Perkins AC, Pimm MV, Hardy JG, Embleton MJ, Baldwin RW, Hardcastle JD (1982) Radioimmunodetection of human colorectal cancers by an anti-tumour monoclonal antibody. Lancet 2:396–400
Farrands PA, Perkins AC, Sulley L, Hopkins JS, Pimm MV, Baldwin RW, Hardcastle JD (1983) Localization of human osteosarcoma by anti-tumour monoclonal antibody 79IT/ 36. J Joint and Bone Surg 65-B:638–640
Goldenberg DM, DeLand FH (1982) History and status of tumour imaging with radiolabelled antibodies. J Biol Response Mod 1:121–136
Kraus FT (1977) Female genitalia. In: Anderson WAD, Kissane JM (eds) Pathology, vol 2. Mosby, St Louis
Mach J-P, Buchegger F, Forni M, Ritschard J, Berche C, Lumbroso J-D, Schreyer M, Giraroet C, Accolla RS, Carrel S (1981) Use of radiolabelled monoclonal anti-CEA antibodies for the detection of human carcinomas by external photoscanning and tomoscintigraphy. Immunol Today 2:239–249
Perkins AC, Whalley DR, Hardy JG (1984) Physical approach for the reduction of dual radionuclide image subtraction artefacts in immunoscintigraphy. Nucl Med Commun 5:501–512
Perkins AC, Pimm MV, Birch MK (1985) The preparation and characterisation of 111Inlabelled 791T/36 monoclonal antibody for tumour immunoscintigraphy. Eur J Nucl Med 10:296–301
Pimm MV, Embleton MJ, Perkins AC, Price HR, Robins RA, Robinson GR, Baldwin RW (1982) In vivo localisation of antiosteogenic sarcoma 79IT monoclonal antibody in osteogenic sarcoma xenografts. Int J Cancer 30:75–85
Symonds EM, Perkins AC, Pimm MV, Baldwin RW, Hardy JG, Williams DA (1985) Clinical implications for immunoscintigraphy in patients with ovarian malignancy: a preliminary study using monoclonal antibody 791T/36. Br J Obstet Gynecol 92:270–276
Williams MR, Perkins AC, Campbell FC, Pimm MV, Hardy JG, Wastie ML, Blamey RW, Baldwin RW (1984) The use of monoclonal antibody 791T/36 in the immunoscintigraphy of primary and metastatic carcinoma of the breast. Clin Oncol 10:375–381
Witesbky E (1929) Disponibilität und Spezifítät alkohollöslicher Strukturen von Organen und bösartigen Geschwülsten. Z Immunitaetsforsch 62:35–73
Pimm MV, Perkins AC, Armitage NC, Baldwin RW (1985) The production of antimouse- IgG antibodies in patients receiving labelled monoclonal antibody for diagnostic immunoscintigraphy. J Nucl Med 26:1011–1023
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© 1986 Springer-Verlag Berlin Heidelberg
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Perkins, A.C., Powell, M.C., Pimm, M.V., Wastie, M.L., Symonds, E.M., Baldwin, R.W. (1986). Immunoscintigraphy of Gynaecological Tumors. In: Winkler, C. (eds) Nuclear Medicine in Clinical Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70947-0_27
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DOI: https://doi.org/10.1007/978-3-642-70947-0_27
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