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Scintigraphy of Lymphokinetics and Lymphatic Neoplasia

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Nuclear Medicine in Clinical Oncology

Abstract

Lymph node (LN) concentration of radioactive colloidal gold was first detected some decades ago [40, 66, 70]. Clinical applications were promoted by zum Winkel [72–74]. The original concepts to scan (metastatic) LN, control the radiation field, and stage malignant lymphonodular diseases [10, 15, 24, 26, 32, 36, 38, 45, 46, 52, 59, 67, 71 – 74] were partly replaced [2, 23, 36, 38, 54–56]. The change in indications was induced by the development of new radiopharmaceuticals, high-resolution gamma cameras, and computers, which paved the way for visualizing lymphokinetics, and thus improving the detection of lymphatic malignancies.

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References

  1. Abramson DI, Dobrin PB (1984) Blood vessels and lymphatics in organ system. Academic Press, New York

    Google Scholar 

  2. Altmeyer P, Munz D, Steinhoff W, Hör G, Holzmann H (1981) Szintigraphische Identifìzierung der Lymphdrainage maligner Rumpfmelanome. Akt Derm 7:127

    Google Scholar 

  3. Anderson KC, Leonard RCG, Canellos GP (1983) High dose gallium imaging in lymphoma. Am J Med 75:327

    Article  PubMed  CAS  Google Scholar 

  4. Andrews GA, Hübner KF, Greenlaw RH (1978) Ga-67 citrate imaging in malignant lymphoma: Final report of cooperative group. J Nucl Med 19:1013

    PubMed  CAS  Google Scholar 

  5. Ariel IM, Resnick MI (1964) The intralymphatic administration of radioactive isotopes and cancer chemotherapeutic drugs. Surgery 55:355

    PubMed  CAS  Google Scholar 

  6. Bekerman C, Port RB, Pang E (1978) Scintigraphic evaluation of childhood malignancies by 67Ga-citrate. Radiology 127:719

    PubMed  CAS  Google Scholar 

  7. Bekerman C, Hoffer PB, Bitran JD (1985) The role of gallium-67 in the clinical evaluation of cancer. Semin Nucl Med 15:72

    Article  Google Scholar 

  8. Botsch H (1983) Galliumszintigraphie (Diagnostik bei entzundlichen Erkrankungen und Tumoren). Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  9. Brascho DJ, Durant JR, Green LE (1977) The accuracy of retroperitoneal ultrasonography in Hodgkin’s disease and non-Hodgkin’s lymphoma. Radiology 125:485

    PubMed  CAS  Google Scholar 

  10. Breit A, Czempiel H, Koemig-Kron K (1969) Die Lymphszintigraphie in der Tumortherapie (Erfahrung an über 800 Tumorpatienten). Strahlentherapie 138:74

    PubMed  CAS  Google Scholar 

  11. Breslow A (1975) Tumor thickness, level of invasion, and node dissection in stage I cutaneous melanoma. Ann Surg 182:572

    Article  PubMed  CAS  Google Scholar 

  12. Chiappa S, Uslenghi C, Bonadonna G, Musumeci R (1970) Endolymphatic radiotherapy in malignant lymphomas-long-term results. Lymphology 1:13

    Google Scholar 

  13. Coates G, Bush RS, Aspin N (1973) A study of ascites using lymphoscintigraphy with 99mTc sulfur colloid. Radiology 107:577

    PubMed  CAS  Google Scholar 

  14. Collier BD, Palmer DW, Wilson JF et al. (1983) Internal mammary lymphoscintigraphy in patients with breast cancer. Radiology 147:845

    PubMed  CAS  Google Scholar 

  15. Deckart H, Liming M, Gebert G, Henze E (1971) Möglichkeiten und Grenzen der abdominellen Lymphszintigraphie im Vergleich zur Lymphographie in der Beurteilung maligner Lymphoblastosen. Dtsch Gesundheitswes 9:391

    Google Scholar 

  16. Dionne L, Friede J, Blais R (1983) Internal mammary lymphoscintigraphy in breast carcinoma-a surgeon’s perspective. Semin Nucl Med 13:35

    Article  PubMed  CAS  Google Scholar 

  17. Duson GL, Thrall H, Stevenson JS, Pinsky SM (1983) 99mTc minicolloid for radionuclide lymphography. Radiology 109:387

    Google Scholar 

  18. Edeling CJ (1983) Ga-67 in pediatric oncology. Clin Nucl Med 8:205

    Article  PubMed  CAS  Google Scholar 

  19. Ege GN (1977) Internal mammary lymphoscintigraphy in breast carcinoma: a study of 1072 patients. Int J Radiat Oncol Biol Phys 2:755

    Article  PubMed  CAS  Google Scholar 

  20. Fairbanks VF, Tauxe WN, Kiely JM, Miller WE (1972) Scintigraphic visualization of abdominal lymph nodes with 99mTc pertechnetate-labeled sulfur colloid. J Nucl Med 13:185

    PubMed  CAS  Google Scholar 

  21. Fawwaz RA, Winchell HS, Frye F, Hemphill W, Lawrence JH (1969) Localization of 58Co and 65Zn — hematoporphyrin complexes in canine lymph nodes. J Nucl Med 10:581

    PubMed  CAS  Google Scholar 

  22. Fawwaz RA, Wang TST, Srivastava SC et al. (1984) Potential of palladium-109-labeled antimelanoma monoclonal antibody for tumor therapy. J Nucl Med 25:796

    PubMed  CAS  Google Scholar 

  23. Fee HJ, Robinson DS, Sample WF et al. (1978) The determination of lymph shed by colloidal gold scanning in patients with malignant melanoma: a preliminary study. Surgery 84:626

    PubMed  CAS  Google Scholar 

  24. Fernholz HJ (1967) Lymphoszintigraphie im Kopf-Hals-Bereich. ROFO 4:106

    Google Scholar 

  25. Földi M, Casley-Smith JR (1983) Lymphangiology. Schattauer, Stuttgart, p 723

    Google Scholar 

  26. Frühling J (1981) Lymph and lymphatic pathophysiology. Radiopharmacol 2:223

    Google Scholar 

  27. Gates GF, Dore EK, Kanchanapoom V (1972) Thoracic duct leakage in neonatal chylo- thorax visualized by 198Au lymphangiography. Radiology 105:619

    PubMed  CAS  Google Scholar 

  28. Handmaker H, Ömara RE (1977) Gallium imaging in pediatrics. J Nucl Med 18:1057

    PubMed  CAS  Google Scholar 

  29. Hay JB, Hobbs BB (1977) The flow of blood to lymph nodes and its relation to lymphocyte traffic and the immune response. J Exp Med 145:31

    Article  PubMed  CAS  Google Scholar 

  30. Henkin RE, Polycyn RE, Quinn JL (1974) Scanning treated Hodgkin’s disease with 67Ga citrate. Radiology 110:151

    PubMed  CAS  Google Scholar 

  31. Herman TS, Jones SE (1978) Systematic restaging in patients with Hodgkin’s disease — a southwest oncology group study. Cancer 42:1976

    Article  PubMed  CAS  Google Scholar 

  32. Höfer R, Benzer H (1967) Die indirekte Lymphographie der Lungen. In: Fellinger K, Höfer R (eds) Radioaktive Isotope in Klinik und Forschung. Urban und Schwarzenberg, München p 410

    Google Scholar 

  33. Hör G, Glaubitt D, Grebe SF, Hampe J, Haubold U et al. (1972) Tumorszintigraphie mit 67Ga. In: Pabst HW, Hör G (eds) Nuklearmedizin — Klinische Leistungsfáhigkeit und technische Entwicklung. Schattauer, Stuttgart, p 318

    Google Scholar 

  34. Hör G, Kempken K, Kriegel H, Langhammer H et al. (1974) Munich report on 67Ga: a review of our experiences in nuclear biology, experimental and clinical nuclear medicine after four years use. Proc. Ist. World Congr. Nucl. Med. Berl., Tokyo 1974 (book of abstr.)

    Google Scholar 

  35. Hör G, Maul FD, Standke R, Munz D (1981) Scintigraphy in oncology. In: IAEA (ed) Medical radionuclide imaging 1980, Vienna, p 487

    Google Scholar 

  36. Hör G (1985) Nuklearmedizinisch-onkologische Einführung. In: Holzmann H, Altmeyer P, Hör G, Hahn K (eds) Dermatologie und Nuklearmedizin. Springer, Berlin Heidelberg New York Tokyo, p 113

    Google Scholar 

  37. Hoffer P (1980) Status of gallium-67 in tumor detection. J Nucl Med 21:394

    PubMed  CAS  Google Scholar 

  38. Holzmann H, Altmeyer P, Hör G, Hahn K (eds) (1985) Dermatologie und Nuklearmedizin. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  39. Hübner KF, King P, Gibbs WD, Partain CL, Washburn LC et al. (1981) Clinical investigations with carbon-11-labelled amino acids using positron emission computerized tomography in patients with neoplastic diseases. Medical radionuclide imaging 1980. IAEA, Vienna, p 515

    Google Scholar 

  40. Hultbom KA, Jonsson L (1955) The use of calloidal 198Au for the detection of lymph nodes in radical excision of the breast. Acta Radiol 43:132

    Google Scholar 

  41. Illig L: Lokale Lymphoszintigraphie in der Diagnostik der malignen Melanome der Haut. In: Holzmann H, Altmeyer P, Hör G, Hahn K (eds) Dermatologie und Nuklearmedizin. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  42. Ito Y, Otsuka N, Nagai K, Muranaka A et al. (1982) Lymphoscintigraphy by subcutaneous injection of 67Ga-citrate. Eur J Nucl Med 7:260

    Article  PubMed  CAS  Google Scholar 

  43. Jung H, Munz DL, Hör G, Frenkel G (1983) Lymphabfluβuntersuchungen mit 99mTc- Antimontrisulfld-Kolloid und 67Ga-Zitrat bei Malignomen im Gesichtsschädel- und Mundhöhlenbereich. Dtsch Z Mund-Kiefer-Gesichts-Chir 7:445

    Google Scholar 

  44. Kaplan WD, Anderson KC, Leonard RCF et al. (1983) High dose gallium in the evaluation of lymphoma (Abstr.). J Nucl Med 24:50

    Google Scholar 

  45. Kappert A (1985) Lehrbuch und Atlas der Angiologie. Erkrankungen der Arterien, Venen, Kapillaren und Lymphgefäβe. Huber, Bern

    Google Scholar 

  46. Langhammer H, Hör G, Pabst HW (1970) Zur diagnostischen Diskrepanz von abdominaler Lymphknotenszintigraphie und röntgenologischer Lymphographie. Rontgenblätter 23:261

    Google Scholar 

  47. Langhammer H, Büll U, Kucharczyk D, Hör G, Frey KW, Pabst HW (1974) Zur Treffsicherheit der abdominalen Lymphknotenszintigraphie in der Tumordiagnostik. Med Welt 25:358

    PubMed  CAS  Google Scholar 

  48. Larson SM, Carrasquillo JA (1984) Nuclear oncology 1984. Semin Nucl Med 14:268

    Article  PubMed  CAS  Google Scholar 

  49. Lepanto PB, Rosenstock J, Littman P (1976) Gallium-67 scans in children with solid tumors. Am J Rontgenol 126:179

    CAS  Google Scholar 

  50. Lofferer O, Mostbeck A: Nuclear medicine techniques in the diagnosis and differential diagnosis of swollen arms and legs. In: (25)

    Google Scholar 

  51. Mansfield CM, Park CH (1985) Contribution of radionuclide imaging to radiation oncology. Semin Nucl Med 15:28

    Article  PubMed  CAS  Google Scholar 

  52. Maul FD, Wenisch HJC, Schumm P-M, Usadel KH, Bittner G et al. (1984) Zur szintigraphischen Differenzierung maligner und benigner Schilddrüsentumoren mit 201T1. In: Verhandlungen der Deutschen Gesellschaft für innere Medizin, vol 90. Bergmann, München, p 1026

    Google Scholar 

  53. Maul FD, Altmeyer P, Bittner G, Wanner U et al. (1985) Die Thallium-201-Szintigraphie in der Diagnostik des metastasierenden malignen Melanoms. In: [38] p. 198

    Google Scholar 

  54. Menon M, Menon S, Strauss HW, Catalona WJ (1977) Demonstration of the existence of canine prostatic lymphatics by radioisotope techniques. J Urol 118:274

    PubMed  CAS  Google Scholar 

  55. Mostbeck A, Partsch H, Kahn P (1985) Quantitative Isotopenlymphographie. In: Holzmann H, Altmeyer P, Hör G, Hahn K (eds) Dermatologie und Nuklearmedizin. Springer, Berlin Heidelberg New York Tokyo, p 426

    Google Scholar 

  56. Munz DL, Altmeyer P, Holzmann H, Encke A, Hör G (1982) Der Stellenwert der Lymphoszintigraphie in der Behandlung maligner Melanome der Haut. Dtsch Med Wochenschr 107:86

    Article  PubMed  CAS  Google Scholar 

  57. Munz DL (1983) Experimentelle und klinische Untersuchungen über die regionäre Lymphdrainage der Haut mit 99mTc markiertem Antimontrisulfid-kolloid — Bedeutung für das maligne Hautmelanom. Habilitationsschrift, Universität Frankfurt

    Google Scholar 

  58. Munz DL, Kötter R, Kornemann I, Brandhorst I, Hör G (1984) Bone marrow scanning versus bone scanning in the early diagnosis of neoplastic involvement of the skeletal system: A comparative parallel study. In: Schmidt HAE, Adam WE (eds) Nuklearmedizin. Schattauer, Stuttgart, p 664

    Google Scholar 

  59. Ochi H, Sawa H, Fukada T et al. (1982) Thallium-201-Chloride thyroid scintigraphy to evaluate benign and/or malignant nodules. Cancer 50:236

    Article  PubMed  CAS  Google Scholar 

  60. Pabst HW, Langhammer H (1980) Klinische Bedeutung des szintigraphischen Geschwulstnachweises mit tumoraffinen Testsubstanzen. Fortschr Med 98:653

    PubMed  CAS  Google Scholar 

  61. Peters PE (1970) Zur Funktion der Lymphknotenbarriere des Menschen — Untersuchung mit 51Cr-markierten Erythrozyten. ROFO 113:1

    Article  Google Scholar 

  62. Potchen EJ, Welch MJ (1968) Radioisotopic assessment of extravascular albumin as an index of lymph transport. Lymphology 1:58

    Google Scholar 

  63. Richman SD, Appelbaum F, Levenson SM (1975) 67Ga radionuclide imaging in Burkitt’s lymphoma. Radiology 117:639

    PubMed  CAS  Google Scholar 

  64. Rosenblum I, Stadler A, Wiznitzer T, Baron J (1982) Radionuclide mammalymphography in the preoperative investigation of suspected breast cancer. In: Schmidt HAE, Rösler H (eds) Nuklearmedizin. Schattauer, Stuttgart, p 830

    Google Scholar 

  65. Savioli M, Mango L, Spagnoli F, Cavallaro A (1983) 201Tl scintigraphy of lymph node metastases in thyroid carcinoma: A case report. Tumor Diagn 3:138

    Google Scholar 

  66. Schenk P (1966) Szintigraphische Darstellung des parasternalen Lymphsystems. Strahlentherapie 130:4

    Google Scholar 

  67. Seitzman DM, Wright R, Halaby FA, Freeman JH (1963) Radioactive lymph angiography as a therapeutic adjunct. Am J Rontgenol 89:140

    CAS  Google Scholar 

  68. Sherman AJ, Ter-Pogossian M, Tocus EC (1953) Lymph node concentration of radioactive colloidal gold following interstitial injection. Cancer 6:1238

    Article  PubMed  CAS  Google Scholar 

  69. Siegl H, Wascher H (1967) Die Szintigraphie der zervikalen Lymphbahnen. Monatsschr Ohrenheilk Laryngol Rhinol 101:409

    CAS  Google Scholar 

  70. Sugarbaker EV, McBride CM (1976) Melanoma of the trunk: the results of surgical excision and anatomic guidelines for predicting nodal metastasis. Surgery 80:22

    PubMed  CAS  Google Scholar 

  71. Thompson CH, Stacker SA, Salehi N et al. (1984) Immunoscintigraphy for detection of lymph node metastases from breast cancer. Lancet 11:1245

    Article  Google Scholar 

  72. Turner DA, Fordham EW, Ali A (1978) Gallium-67 imaging in the management of Hodgkin’s disease and other malignant lymphomas. Semin Nucl Med 8:205

    Article  PubMed  CAS  Google Scholar 

  73. Walker LA (1950) Localization of radioactive colloids in lymph nodes. J Lab Clin Med 36:440

    PubMed  CAS  Google Scholar 

  74. Winkler C (1985) Nuklearmedizinische Tumordiagnostik. In: Hundeshagen H (ed) Nuklearmedizin, Part 3, Diagnostik n, Handbuch der medizinischen Radiologie. Springer, Berlin Heidelberg New York Tokyo, p 407

    Google Scholar 

  75. Zum Winkel K, Becker J, Jahns E, Scheurlen H, Herzfeld U (1967) Indikationsstellung und Dosimetrie bei der endolymphatischen Therapie mit J131-Lipiodol. Strahlentherapie 133:4

    Google Scholar 

  76. Zum Winkel K (1972) Lymphologie mit Radionukliden. Hoffmann, Berlin

    Google Scholar 

  77. Zum Winkel K, Herbst H (1974) Möglichkeiten und Grenzen der Lymphszintigraphie. Dtsch Ärztebl 10:69

    Google Scholar 

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  1. Zentrum der Radiologie und Dermatologie, Klinikum der Johann-Wolfgang-Goethe-Universität, Theodor-Stern-Kai 7, D-6000, Frankfurt am Main 70, Germany

    G. Hör

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  1. G. Hör
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  2. D. L. Munz
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Editors and Affiliations

  1. Institute for Clinical and Experimental Nuclear Medicine, University of Bonn, Sigmund-Freud-Str. 25, D-5300, Bonn-Venusberg, Germany

    Cuno Winkler M.D., Ph.D. (hon.) (Professor of Nuclear Medicine) (Professor of Nuclear Medicine)

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© 1986 Springer-Verlag Berlin Heidelberg

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Hör, G. et al. (1986). Scintigraphy of Lymphokinetics and Lymphatic Neoplasia. In: Winkler, C. (eds) Nuclear Medicine in Clinical Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70947-0_16

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  • DOI: https://doi.org/10.1007/978-3-642-70947-0_16

  • Publisher Name: Springer, Berlin, Heidelberg

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