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Role of Metabolism in Pesticide Selectivity and Toxicity

  • Conference paper
Toxicology of Pesticides

Part of the book series: NATO ASI Series ((ASIH,volume 13))

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Abstract

Ideally, pesticides will be selectively toxic to target organisms and non-toxic to non-target or desirable organisms. Theoretically, this might be achieved by several means. First, a pesticidal chemical might be designed or selected which uniquely attacks a functional or structural bio-system that is peculiar to the pest organism and which is either absent in or less critical to the desirable organism. Examples of this would include: the use of red squill as a rodenticide, particularly useful because rats do not effectively vomit the material whereas other mammals do; or the use of chitin synthetase inhibitors which are selectively toxic to invertebrates with exoskeleton and nontoxic, or generally much less toxic, to mammalian organisms; or the use of juvenile hormones which affect the peculiar metamorphic development of insects.

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Author information

Authors and Affiliations

  1. Department of Environmental Health, SC-34, School of Public Health and Community Medicine, University of Washington, Seattle, WA, 98195, USA

    S. D. Murphy Ph.D.

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  1. S. D. Murphy Ph.D.
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Editors and Affiliations

  1. Department of Environmental Health, University of Washington, 98195, Seattle, WA, USA

    Lucio G. Costa  & Sheldon D. Murphy  & 

  2. Institute of Experimental Sciences, University of Milan, Via Balzaretti 9, I-20133, Milan, Italy

    Corrado L. Galli

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© 1987 Springer-Verlag Berlin Heidelberg

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Murphy, S.D. (1987). Role of Metabolism in Pesticide Selectivity and Toxicity. In: Costa, L.G., Galli, C.L., Murphy, S.D. (eds) Toxicology of Pesticides. NATO ASI Series, vol 13. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70898-5_3

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  • DOI: https://doi.org/10.1007/978-3-642-70898-5_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70900-5

  • Online ISBN: 978-3-642-70898-5

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