Abstract
The organophosphate insecticide, parathion, is a potent inhibitor of acetylcholinesterase both in the central and peripheral nervous systems. Acute exposure to this pesticide can cause a number of physical symptoms which are ameliorated as tolerance develops (Costa et al., 1982). There is, however, evidence of continuing behavioral deficits in humans following chronic exposure (Clark, 1971). These effects include impairment in concentration, decreased cognitive abilities, memory impairment, depression and irritability (Levin and Rodnitsky, 1976).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Almli, C.R. and R.S. Fisher. Infant rats: sensorimotor ontogeny and effects of substantia nigra destruction. Brain Res.Bull.2(6):425–459, 1977.
Beninger, R.J. and B.A. Wirsching. Effects of altered cholinergic function on working and reference memory in the rat. Can. J. Physiol. Pharmacol. 64:376–382, 1985.
Clark, G. Organophosphate insecticides and behavior, a review. Aerospace Med. 42(7):735–740, 1971.
Costa, L.G., B.W. Schwab and S.D. Murphy. Tolerance to anticholinesterase compounds in mammals. Toxicology 25:79–97, 1982.
Coyle, J.T. and H.I. Yamamura. Neurochemical aspects of the ontogenesis of cholinergic neurons in the rat brain. Brain Res. 118:429, 1976.
Dobbing, J. The Later Development of the brain and its vulnerability. In: J. Davis and J. Dobbing, eds. Scientific Foundations of Pediatrics, 565–575, 1974.
Dorner, G. Hormones and brain differentiation. Elsevier, Amsterdam, 243–263, 1976.
Douglas, R. Cues for Spontaneous Alternation. J.Comp.Physiol.Psychol. 62(2):171–183, 1966.
Khera, K.S. and D.J. Clegg. Perinatal toxicity of pesticides. Canad.Med.Assoc.J. 100:167–172, 1969.
Kokkinidis, L. and H. Anisman. Dissociation of the effects of scopolamine and d-amphetamine on a spontaneous alternation task. Pharm.Biochem.Behav. 5(3): 293–297, 1976.
Leathwood, P. Influence of early undernutrition on behavioral development and learning in rodents. In: G. Gottlieb, ed. Early Influences, 187–209, 1978.
Levin, H.S. and R.L. Rodnitzky. Behavioral effects of organophosphate pesticides in man. Clin.Toxicol. 9(3):391–405, 1976.
Olton, D. The use of animal models to evaluate the effects of neurotoxins on cognitive processes. Neurobehav.Toxicol.Teratol. 5(6):635–640, 1983.
Richardson, D.L., A.G. Karczmar and C.L. Scudder. Effects of pre-natal cholinergic drug treatment on post-natal behavior and brain chemistry in mice. Fed.Proc. 31:596, 1972.
Robens, J.F. Teratologic studies in carbaryl, diazinon, noria, disulfiram and thiram in small laboratory aninmals. Toxicol.Appl.Pharmacol. 15:152–163, 1969.
Spyker, J.M. and D.L. Avery. Neurobehavioral effects of prenatal exposure to the organophosphate diazinon in mice. J. Toxicol and Env. Health. 3:989–1002, 1977.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Stamper, C.R., Balduini, W., Murphy, S.D., Costa, L.G. (1987). Behavioral and Biochemical Effects of Early Postnatal Parathion Exposure in the Rat. In: Costa, L.G., Galli, C.L., Murphy, S.D. (eds) Toxicology of Pesticides. NATO ASI Series, vol 13. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70898-5_26
Download citation
DOI: https://doi.org/10.1007/978-3-642-70898-5_26
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-70900-5
Online ISBN: 978-3-642-70898-5
eBook Packages: Springer Book Archive