Insect Aging pp 200-206 | Cite as

Protein Synthesis in Relation to Insect Aging: An Overview

  • L. Levenbook


Nearly 40 years ago, V.B. Wigglesworth (1948) stated: “Insects…are so varied in form, so rich in species, and adapted to such diverse conditions of life that they afford unrivalled opportunities for physiological study…. They are extremely tolerant of operation; they are so varied in form and habit that some species suited to the problem in hand can surely be found; and their small size makes it possible for the observer to be constantly aware of the whole while focusing his attention upon the part.” One “problem in hand” for which insects are particularly well suited is that of aging, a function of the insect’s life span. The latter varies widely among insect taxa, ranging from about a day for some adult mayflies, up to two years for certain roaches, and as long as 15 years for well-nourished ant queens.


Protein Synthesis Chain Elongation Accessory Gland Musca Domestica Mech Ageing 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Baker GT, Schmidt T (1976) Changes in 80 S ribosomes from Drosophila melanogaster with age. Experientia 32:1505–1506PubMedCrossRefGoogle Scholar
  2. Baker GT, Zschunke RE, Podgorski EM Jr (1979) Alteration in thermal stability of ribosomes from Drosophila melanogaster with age. Experientia 35:1053–1054PubMedCrossRefGoogle Scholar
  3. Baumann P, Chen PS (1969) Alterung und Proteinsynthese bei Drosophila melanogaster. Rev Suisse Zool 75:1051–1055Google Scholar
  4. Beckendorf GW, Stephen WP (1970) The effect of aging on the multiple molecular esterase forms taken from tissues of Periplaneta americana (L). Biochim Biophys Acta 201:101–108PubMedCrossRefGoogle Scholar
  5. Burns AL, Kaulenas MS (1979) Analysis of the translational capacity of the male accessory gland during aging of Acheta domesticas. Mech Ageing Dev 11:153–169PubMedCrossRefGoogle Scholar
  6. Chen PS (1972) Amino acid pattern and rate of protein synthesis in aging Drosophila. In: Rockstein M, Baker GT III (eds) Molecular genetic mechanisms in development and aging. Academic Press, London New York, p 199Google Scholar
  7. Clarke JM, Maynard Smith J (1966) Increase in the rate of protein synthesis with age in Drosophila subobscura. Nature (London) 209:627–629CrossRefGoogle Scholar
  8. Dingley F, Maynard Smith J (1969) Absence of life shortening effect of amino-acid analogues on Drosophila. Exp Gerontol 4:145–149PubMedCrossRefGoogle Scholar
  9. Dunn GR, Wilson TG, Jacobson KG (1969) Age-dependent changes in alcohol dehydrogenase in Drosophila. J Exp Zool 171:185–190PubMedCrossRefGoogle Scholar
  10. Hall JC (1969) Age-dependent enzyme changes in Drosophila melanogaster. Exp Gerontol 4:207–222PubMedCrossRefGoogle Scholar
  11. Harrison BJ, Holliday R (1967) Senescence and the fidelity of protein synthesis in Drosophila. Nature (London) 213:990–992CrossRefGoogle Scholar
  12. Heslop JP (1967) Effect of age on [14 C] valine turnover into locust wing protein. Biochem J 104:5P–6PGoogle Scholar
  13. Hosbach HA, Kubli E (1979a) Transfer RNA in aging Drosophila. I. Extent of aminoacetylation. Mech Ageing Dev 10:131–140PubMedCrossRefGoogle Scholar
  14. Hosbach HA, Kubli E (1979b) Transfer RNA in aging Drosophila: II. Isoacceptor patterns. Mech Ageing Dev 10:141–149PubMedCrossRefGoogle Scholar
  15. Jit I, Sharma SP (1983) Age related protein changes in the banana fruit fly. Exp Gerontol 18:365–373PubMedCrossRefGoogle Scholar
  16. Laidlaw SA, Moldave K (1981) Protein synthesis and aging. In: Schimke RT (ed) Biological mechanisms in aging. NIH Publ No 81–2194, Bethesda MD, p 326Google Scholar
  17. Lang CA, Lau HY, Jefferson DJ (1965) Protein and nucleic acid changes during growth and aging in the mosquito. Biochem J 95:372–377PubMedGoogle Scholar
  18. Levenbook L, Krishna I (1971) Effect of ageing on amino acid turnover and rate of protein synthesis in the blowfly Phormia regina. J Insect Physiol 17:9–12PubMedCrossRefGoogle Scholar
  19. Massie HR, Baird MB, McMahon MM (1975a) Changes in the structure of the DNA of Drosophila melanogaster during development and aging. Mech Ageing Dev 4:113–122PubMedCrossRefGoogle Scholar
  20. Massie HR, Baird MB, McMahon (1975b) Loss of mitochondrial DNA with aging in Drosophila melanogaster. Gerontología 21:231–238PubMedCrossRefGoogle Scholar
  21. Massie HR, Baird MB, Williams TR (1975c) Lack of increase in DNA crosslinking in Drosophila melanogaster. Gerontología 21:73–80PubMedCrossRefGoogle Scholar
  22. Owenby RK, Stulberg MP, Jacobson KB (1979) Alteration of the Q family on transfer RNAs in adult Drosophila melanogaster. Mech Ageing Dev 11:91 – 103PubMedCrossRefGoogle Scholar
  23. Parker J, Flanagon J, Murphy J, Gallant J (9181) On the accuracy of protein synthesis in Drosophila melanogaster. Mech Ageing Dev 16:127–139CrossRefGoogle Scholar
  24. Poison CDA, Webster GC (1982) Age related DNA fragmentation in two varieties of Drosophila melanogaster, Phaseolus (cotyledons), and three tissues of the mouse. Exp Gerontol 17:11 – 17CrossRefGoogle Scholar
  25. Richardson A (1981) The relationship between aging and protein synthesis. In: Florini JR (ed) CRC handbook of biochemistry in aging. CRC Press, Boca Raton, p 79Google Scholar
  26. Richardson A, Birchenall-Sparks MC (1983) Age-related changes in protein synthesis. In: Rothstein M (ed) Review of biological research in aging, Alan R Liss, New York, p 255Google Scholar
  27. Rockstein M, Baker GT (1974) Effects of X-irradiation of pupae on aging of the thoracic flight muscle of the adult housefly Musca domestica L. Mech Ageing Dev 3:271 – 278CrossRefGoogle Scholar
  28. Schmidt T, Baker GT (1979) Analysis of ribosomal proteins from adult Drosophila melanogaster in relation to age. Mech Agein Dev 11:105–112CrossRefGoogle Scholar
  29. Schrodinger E (1945) What is life? Cambridge Univ Press, CambridgeGoogle Scholar
  30. Sharma SP, Jit I, Rai N (1984) Age related changes in nucleic acids and protein in Callosobruchus maculatus Fabr. (Coleoptera). Gerontology 30:26–29PubMedCrossRefGoogle Scholar
  31. Utsumi K, Natori S (1980) Changes in head proteins of Sarcophaga peregrina with age. FEBS Lett 111:419–422PubMedCrossRefGoogle Scholar
  32. Wattiaux JM, Libion-Mannaert M, Delcour J (1971) Protein turnover and protein synthesis following actinomycin-D injection as a function of agein Drosophila melanogaster. Gerontología 17:289–299PubMedCrossRefGoogle Scholar
  33. Webster GC, Webster SL (1979) Decreased protein synthesis by microsomes from aging Drosophila melanogaster. Exp Gerontol 14:343–348PubMedCrossRefGoogle Scholar
  34. Webster GC, Webster SL (1981) Aminoacetylation of tRNA by cell-free preparations from aging Drosophila melanogaster. Expt Gerontol 16:487–494CrossRefGoogle Scholar
  35. Webster GC, Webster SL (1982) Effects of age on the post-initiation stages of protein synthesis. Mech Agein Dev 18:369–378CrossRefGoogle Scholar
  36. Webster GC, Webster SL (1983) Decline in synthesis of elongation factor one (EF-1) precedes the decreased synthesis of total protein in aging Drosophila melanogaster. Mech Ageing Dev 22:121–128PubMedCrossRefGoogle Scholar
  37. Webster GC, Webster SL (1984) Specific disappearance of translatable messenger RNA for elongation factor one in aging Drosophila melanogaster. Mech Ageing Dev 24:335–342PubMedCrossRefGoogle Scholar
  38. Webster GC, Beachell VT, Webster SL (1980) Differential decrease in protein synthesis by microsomes from aging Drosophila melanogaster. Exp Gerontol 15:495–497PubMedCrossRefGoogle Scholar
  39. Webster GC, Webster SL, Landis WA (1981) The effect of age on the initiation of protein synthesis in Drosophila melanogaster. Mech Ageing Dev 16:71–79PubMedCrossRefGoogle Scholar
  40. Wigglesworth VB (1948) The insect as a medium for the study of physiology. Proc R Soc London Ser B 135:430–446CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • L. Levenbook
    • 1
  1. 1.National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, Laboratory of Physical BiologyNational Institutes of HealthBethesdaUSA

Personalised recommendations