The study of nuclear changes with age is primarily concerned with alterations in chromatin structure and function. This relationship is of fundamental importance to both developmental biology and gerontology. Understanding the modulation of chromatin structure is essential to an understanding of the control of gene expression in eukaryotes and of the control of cellular differentiation and senescence.
KeywordsCage Fractionation Disulfide Estradiol Tral
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- Browder LW (1980) Developmental biology. Saunders, Philadelphia, p 158Google Scholar
- Brown SW (1966) Heterochromatin. Science 151:417–425Google Scholar
- Chaturvedi MM, Kanungo MS (1983) Analysis of chromatin of brain of young and old rats by micrococcal nuclease and DNAse. I. Biochem Int 6:357–363Google Scholar
- Clark AM, Rockstein M (1964) Aging in insects. In: Physiology of insects, vol II, chap6. Academic Press, London New YorkGoogle Scholar
- Hancock R, Hughes ME (1982) Organization of DNA in the interphase nucleus. Biol Cell 44:201–212Google Scholar
- Panno JP (1984) Computer analysis of age-related chromatin condensation in the somatic cells of the housefly Musca domestia. MSc Thesis, Simon Fraser UnivGoogle Scholar
- Panno JP, Nair KK (1986) Age-related chromatin condensation in flight muscle nuclei of the adult male housefly, Musca domestica. Exp Gerontol (in press)Google Scholar
- Porter KR, Bonneville MA (1973) Fine structure of cells and tissues. Lea and Febiger, PhiladelphiaGoogle Scholar
- Sadopogal A, Bonner J (1970) Proteins of interphase and metaphase chromosomes compared. Biochem Biophys Acta 207:227–239Google Scholar
- Sherwood EM, Bartels PH, Wied GL (1976) Feature selection in cell image analysis: Use of the ROC curve. Acta Cytol 20:254–260Google Scholar
- Stryer L (1981) Biochemistry, 2nd edn. Freeman, San Francisco, p597Google Scholar
- Vidal B, Schluter G, Moore GW (1973) Cell nucleus pattern recognition: Influence of staining. Acta Cytol 17:510–515Google Scholar
- Vogelstein B, Purdoll DM, Coffey DS (1980) Supercoiled loops and eucaryotic DNA replication. Cell 22:79–85Google Scholar