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Time-Resolved Fluorescence of Hematoporphyrin Derivative in Tumor Cells and Animal Tissues

  • H. Schneckenburger
  • J. Feyh
  • A. Götz
  • D. Jocham
  • E. Unsöld
Conference paper

Abstract

Hematoporphyrin derivative (Hpd), a complex mixture of porphyrins with tumor-localizing and photosensitizing properties, is used increasingly for diagnosis /1,2/ and photodynamic therapy (PDT) /3/ of cancer. Tumor diagnosis is based on the detection of fluorescent Hpd components. These components have overlapping emission spectra, but can be differentiated on the basis of their decay times in the nanosecond range /4,5/. PDT has so far been correlated with a cytotoxic effect due to the formation of singlet oxygen (after intermolecular energy transfer Hpd→02 /6/) or Hpd radicals /7/.

Keywords

Fluorescent Component Fluorescence Decay Curve Amelanotic Melanoma Hematoporphyrin Derivative Intermolecular Energy Transfer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin, Heidelberg 1986

Authors and Affiliations

  • H. Schneckenburger
    • 1
  • J. Feyh
    • 2
  • A. Götz
    • 2
  • D. Jocham
    • 3
  • E. Unsöld
    • 1
  1. 1.Gesellschaft für Strahlen- und Umweltforschung mbH MünchenAbt. Angewandte OptikNeuherbergGermany
  2. 2.Institut für Chirurgische ForschungGermany
  3. 3.Urologische Klinik und Poliklinik der Universität München, Klinikum GroßhadernMünchen 70Germany

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