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Glutamate and GABA Receptors of Insect Muscles: Biochemical Identification and Interactions with Insecticides

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Approaches to New Leads for Insecticides

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

Abstract

Because of the continuous development of insect resistance to insecticides it is important to develop new insecticides which have different structures and different modes of action. The standard approach used by the insecticide industry has been to synthesize chemicals of varying structures and screen them for toxicity to in-sects. After the proven success of a compound, scientists study its mechanism of action and search for its molecular target. It may be more profitable to reverse the sequence and exploit the wealth of structures of drugs that are known to act on vital proteins in the insect body, as models for synthesis of new generations of insecticides.

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Author information

Authors and Affiliations

  1. Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland, 21201, USA

    A. T. Eldefrawi

Authors
  1. M. E. Eldefrawi
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  2. I. M. Abalis
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  3. M. T. Filbin
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  4. A. T. Eldefrawi
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Editor information

Editors and Affiliations

  1. Schering AG, Agriculture Research, P.O. Box 650311, 1000, Berlin 65, Germany

    Harald C. von Keyserlingk , Albert Jäger  & Christoph von Szczepanski ,  & 

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© 1985 Springer-Verlag Berlin Heidelberg 1985

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Eldefrawi, M.E., Abalis, I.M., Filbin, M.T., Eldefrawi, A.T. (1985). Glutamate and GABA Receptors of Insect Muscles: Biochemical Identification and Interactions with Insecticides. In: von Keyserlingk, H.C., Jäger, A., von Szczepanski, C. (eds) Approaches to New Leads for Insecticides. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70821-3_9

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  • DOI: https://doi.org/10.1007/978-3-642-70821-3_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70823-7

  • Online ISBN: 978-3-642-70821-3

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