Can Mode of Action Studies Guide Chemical Synthesis?
Chemical industry has been exploring alternative means of finding new insecticides to supplement traditional screening of chemicals. The need to reexamine the means of finding active compounds was brought about partly by a decreased success rate coming from straightforward bioassay screens (Menn 1983) and partly by the realization that much activity could well have been missed in the past. This is particularly true of behavior-modifying chemicals when screens are designed only to detect toxicity.
KeywordsLactone Benzimidazole Cholinesterase Carbamate Rotenone
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