Can Mode of Action Studies Guide Chemical Synthesis?
Chemical industry has been exploring alternative means of finding new insecticides to supplement traditional screening of chemicals. The need to reexamine the means of finding active compounds was brought about partly by a decreased success rate coming from straightforward bioassay screens (Menn 1983) and partly by the realization that much activity could well have been missed in the past. This is particularly true of behavior-modifying chemicals when screens are designed only to detect toxicity.
KeywordsNeuromuscular Junction Burst Discharge Nerve Impulse Flight Muscle Musca Domestica
Unable to display preview. Download preview PDF.
- Adams ME (1978) Neurophysiological correlates of pyrethroid and DDT-type insecticide poisoning in the house fly Musca domestica L. Ph D Dissertation, Univ California, RiversideGoogle Scholar
- Bradflsch GA, Miller TA (1985) Behavioral and electrophysiological investigation of 1-(7-ethoxy)- geranyl-2-methyl benzimidazole on the house fly, Musca domestica. Pestic Sci (in press)Google Scholar
- Matsumura F, Ghiasuddin SM (1983) Evidence for similarities between cyclodiene type insecticides and picrotoxinin in the action mechanisms. J Environ Sci Health 18B: 1–14Google Scholar
- Menn J J (1983) Present insecticides and approaches to discovery of environmentally acceptable chemicals for pest management. In: Whitehead DL, Bowers WS (eds) Natural products for innovative pest management. Plenum Press, New York London, p 5Google Scholar
- Miller TA, Salgado VL, Irving SN (1983) The kdr factor in pyrethroid resistance. In: Georghiou GP, Saito T (eds) Pest resistance to pesticides: Challenges and prospects. Plenum Press, New York London, p 353Google Scholar
- Mulloney B (1969) Interneurons in the central nervous system of flies and the start of flight. J Comp Physiol 64: 243–253Google Scholar
- Omer SM, Georghiou GP, Irving SN (1980) DDT/pyrethroid resistance interrelationships in Anopheles stephensi. Mosquito News 40: 200–209Google Scholar
- Sparks TC, Shour MH, Wellemeyer EG (1982) Temperature-toxicity relationships of pyrethroids on three lepidopterans. J Econ Entomol 75: 643–646Google Scholar
- Usherwood PNR, Grundfest H (1965) Peripheral inhibition in skeletal muscle of insects. J Neuro- physiol 28: 497–518Google Scholar