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Homology Among Oncogenes

  • Chapter
Retroviruses 4

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 123))

Abstract

At the heart of current research in cancer is the finding that genes whose products are directly implicated in oncogenesis have counterparts in normal cells (Bishop 1983; Hunter 1984). Such cancer genes, termed oncogenes, were first garnered via the agency of retroviruses, since they constitute an integral part of the genomes of several acutely transforming retroviruses (Bishop and Varmus 1982). The first viral oncogene identified was src, the transforming gene of Rous sarcoma virus (RSV) (Stehelin et al. 1976). The genome of RSV contained src sequences in addition to the genes required for replication and virion formation. However, all other acutely transforming retroviruses identified to date are unable to support their replication, because transforming sequences are acquired at the expense of viral genes whose products are essential for propagation. Consequently all acutely transforming retroviruses are defective for replication (Bishop and Varmus 1982; Verma 1983).

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  1. Molecular Biology and Virology Laboratory, Salk Institute for Biological Studies, P.O. Box 85800, San Diego, CA, 92138-9216, USA

    C. Van Beveren & I. M. Verma

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  1. C. Van Beveren
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  1. School of Medicine, Department of Microbiology, University of Southern California, 2025 Zonal Avenue HMR 401, 90033, Los Angeles, CA, USA

    Peter K. Vogt

  2. The Wistar Institute, 36th Street at Spruce, 19104, Philadelphia, PA, USA

    Hilary Koprowski

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Van Beveren, C., Verma, I.M. (1986). Homology Among Oncogenes. In: Vogt, P.K., Koprowski, H. (eds) Retroviruses 4. Current Topics in Microbiology and Immunology, vol 123. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70810-7_4

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  • DOI: https://doi.org/10.1007/978-3-642-70810-7_4

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