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The Viral Tyrosine Protein Kinases

  • Chapter
Retroviruses 4

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 123))

Abstract

The acutely transforming retroviruses have revealed the existence of more than twenty different genes with oncogenic potential. Seven of these — src, abl, yes, erbB, fps (fes), fgr, fms, and ros — encode proteins with intrinsic tyrosine protein kinase activity. The inappropriate phosphorylation of cellular proteins is likely to play a central and crucial role in the malignant transformation of cells in which these genes are expressed.

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  1. Molecular Biology and Virology Laboratory, The Salk Institute, P.O. Box 85800, San Diego, CA, 92138, USA

    B. M. Sefton

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  1. School of Medicine, Department of Microbiology, University of Southern California, 2025 Zonal Avenue HMR 401, 90033, Los Angeles, CA, USA

    Peter K. Vogt

  2. The Wistar Institute, 36th Street at Spruce, 19104, Philadelphia, PA, USA

    Hilary Koprowski

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Sefton, B.M. (1986). The Viral Tyrosine Protein Kinases. In: Vogt, P.K., Koprowski, H. (eds) Retroviruses 4. Current Topics in Microbiology and Immunology, vol 123. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70810-7_3

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  • DOI: https://doi.org/10.1007/978-3-642-70810-7_3

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