Tachyphylaxis and Local Anesthetics
Tachyphylaxis is frequently associated with long, continued local anesthesia . It is manifested clinically as a reduction in the spread and intensity of nerve blockade, becoming with observable with repeated injections. However, studies of single nerves or nerve fibers in vitro do not show any such effect. Nerve block obtained with a local anesthetic can be reversed and reinstituted almost indefinitely by washing out and rebathing the preparation with drug, with no apparent evidence of resistance to the action of the drug. Therefore, when increasing resistance to repeated injections occurs clinically, it may be profitable to seek other causes for what may be termed “pseudotachyphylaxis”.
KeywordsCatheter Adrenaline Dura Bupivacaine Cough
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- 1.Bromage PR (1978) Epid ural Analgesia. Saunders, Philadelphia, p 100.Google Scholar