Hemodynamic Effects and Mechanism of Action of Dihydroergotamine in Epidural Anesthesia

  • M. Zimpfer
Conference paper
Part of the Anaesthesiologie und Intensivmedizin / Anaesthesiology and Intensive Care Medicine book series (A+I, volume 176)


Relative cardiovascular stability has been found to be one of the major advantages of epidural anesthesia and, depending on the nature of the case, a moderate degree of hypotension may be tolerated before a correction becomes necessary. However, if the arterial pressure declines, it may be difficult to compensate for the dilated vascular bed resulting from sympathetic paralysis by means of fluid substitution alone. Impairment of circulatory compensatory mechanisms, activated by a decrease in perfusion pressure, may necessitate immediate treatment if the venous return is restricted by a loss of effective blood volume from hemorrhage or by postural pooling in regions of vasodilatation.


Pulmonary Artery Pressure Epidural Anesthesia Hemodynamic Effect Femoral Flow Total Peripheral Resistance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Bergenwald L, Ecklund B, Kaijser L, Klingenström P (1972) Haemodynamic effects of dihydroergotamine during spinal anaesthesia in man. Acta Anaesth Scand 12:235–239CrossRefGoogle Scholar
  2. 2.
    Bergmann H (1972) 20 Jahre Spinalanaesthesie, ein klinischer Erfahrungsbericht. Anaesthesist 21: 133–141PubMedGoogle Scholar
  3. 3.
    Bonica JJ, Kennedy WF, Akamatsu TJ, Gerbrrshagen H (1972) Circulatory effects of peridural block III. Effects of acute blood loss. Anesthesiology 36:219–227PubMedCrossRefGoogle Scholar
  4. 4.
    Bromage PR (1978) Epidural Analgesia. Saunders, PhiladelphiaGoogle Scholar
  5. 5.
    Castenfors J, Lindblad LE, Mortasawi A (1975) Effects of dihydroergotamine on peripheral circulation during epidural anaesthesia in man. Acta Anaesth Scand 19:79–84PubMedCrossRefGoogle Scholar
  6. 6.
    Clark BJ, Chu D, Aellig WH (1978) In: Berde B, Schild HO (eds) Ergot alkaloids and related compounds. Springer, Berlin Heidelberg New York, p 65 (Handbook of experimental pharmacology, vol 49)Google Scholar
  7. 7.
    Innes IR (1962) Identification of the smooth muscle excitatory receptors for ergot alkaloids. Br J Pharmacol Chemother 19:120–128PubMedCrossRefGoogle Scholar
  8. 8.
    Kennedy WF Jr, Bonica JJ, Akamatsu TJ, Ward RJ, Martin WE, Grinstein A (1968) Cardiovascular and respiratory effects of subarachnoid block in the presence of acute blood loss. Anesthesiology 29:29–35PubMedCrossRefGoogle Scholar
  9. 9.
    Mellander S, Nordenfelt I (1970) Comparative effects of dihydroergotamine and noradrenaline on resistance, exchange and capacitance function in the peripheral circulation. Clin Sci 39:183–201PubMedGoogle Scholar
  10. 10.
    Müller-Schweinitzer E, Stürmer E (1974) Investigations on the mode of action of ergotamine in the isolated femoral vein of the dog. Br J Pharmacol 51:441–446PubMedCrossRefGoogle Scholar
  11. 11.
    Zimpfer M, Fitzal S, Tonczar L (1979) Aufhebung des Blutdruckabfalls bei Spinalanaesthesie durch Dihydroergotamin (DHE). Region Anaesth 2:43–47Google Scholar
  12. 12.
    Zimpfer M, Fitzal S, Ilias W, Raberger G, Stanek B (1980) Cardiovascular effects of dihydroergotamine in high epidural analgesia and mild acute hypovolemia. Region Anaesth 5:11–14Google Scholar
  13. 13.
    Zimpfer M, Schwarz M, Stanek B, Raberger G (1981) Cardiovascular effects of dihydroergotamine during epidural anaesthesia in dogs. Pharmacology 23:305–309PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • M. Zimpfer

There are no affiliations available

Personalised recommendations