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Microcirculatory Function in Pathophysiological Conditions

  • Conference paper
Book cover Organfunktion und Stoffwechsel in der perioperativen Phase

Abstract

The physiological function of the microcirculation is to supply nutrients to and remove waste products from the tissues. Three physiological variables are of primary importance for this overall function of the microcirculation:

  1. 1.

    Local and overall distribution of vascular resistance, which determines the magnitude and distribution of blood flow and intravascular blood volume

  2. 2.

    The size of the surface area available for exchange of substances between blood and tissue

  3. 3.

    The permeability of the vascular wall to the materials exchanged

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References

  1. Appelgren KL, Lewis DH (1972) Capillary flow and capillary transport in dog skeletal muscle in hemorrhagic shock. Eur Surg Res 4:29–45

    Article  PubMed  CAS  Google Scholar 

  2. Bagge U, Amundson B, Lauritzen C (1980) White blood cell deformability and plugging of skeletal muscle capillaries in hemorrhagic shock. Acta Physiol Scand 108:159–163

    Article  PubMed  CAS  Google Scholar 

  3. Colantuoni A, Bertuglia S, Intaglietta M (1984) Effects of anaesthesia on the spontaneous activity of the microvasculature. Int J Microcirc Clin Exp 3:13–28

    PubMed  CAS  Google Scholar 

  4. Dahlberg JB, Lewis DH (1973) Effect of hemorrhagic shock on capillary transport in dog skeletal muscle. Bibl Anat 12:297–302

    PubMed  CAS  Google Scholar 

  5. Engler RL, Schmid-Schönbein GW, Pavelec RS (1983) Leukocyte capillary plugging in myocardial ischemia and reperfusion in the dog. Am J Pathol 111:98–111

    PubMed  CAS  Google Scholar 

  6. Funk W, Endrich B, Messmer K, Intaglietta M (1983) Spontaneous arteriolar vasomotion as a determinant of peripheral vascular resistance. Int J Microcirc Clin Exp 2:11–25

    PubMed  CAS  Google Scholar 

  7. Johansson B, Bohr DF (1966) Rhythmic activity in smooth muscle from small subcutaneous arteries. Am J Physiol 210:801–806

    PubMed  CAS  Google Scholar 

  8. Johnson PC, Intaglietta M (1976) Contributions of pressure and flow sensitivity to autoregulation in mesenteric arterioles. Am J Physiol 213:1686–1698

    Google Scholar 

  9. Lindbom L (1983) Microvascular blood flow distribution in skeletal muscle. Acta Physiol Scand [Suppl] 525

    Google Scholar 

  10. Longnecker DE, Harris, PD (1980) Microcirculatory actions of general anesthetics. Fed Proc 39:1580–1583

    PubMed  CAS  Google Scholar 

  11. Reneman RS, Slaaf DW, Lindbom L, Tangelder GJ, Arfors KE (1980) Muscle blood flow disturbances produced by simultaneously elevated venous and total muscle tissue pressure. Microvasc Res 20:307–318

    Article  PubMed  CAS  Google Scholar 

  12. Schmid-Schönbein H (1976) Critical closing pressure or yield shear stress as a cause of disturbed peripheral circulation. Acta Chir Scand 465:10–19

    Google Scholar 

  13. Siegel G (1983) Principles of vascular rhythmogenesis. Prog Appl Microcirc 3:40–62

    Google Scholar 

  14. Smedegard G (1985) Mediators of vascular permeability in inflammation. Prog Appl Microcirc 7:96–112

    Google Scholar 

  15. Vanhoutte PM (1978) Heterogeneity in vascular smooth muscle. In: Kaley G, Altura BM (eds) Microcirculation, vol 2. University Park Press, Baltimore, pp 181–309

    Google Scholar 

  16. Zweifach BW (1961) Functional behaviour of the microcirculation. Thomas, Springfield

    Google Scholar 

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© 1985 Springer-Verlag Berlin Heidelberg

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Gaehtgens, P. (1985). Microcirculatory Function in Pathophysiological Conditions. In: Reinhart, K., Eyrich, K. (eds) Organfunktion und Stoffwechsel in der perioperativen Phase. Anaesthesiologie und Intensivmedizin / Anaesthesiology and Intensive Care Medicine, vol 180. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70798-8_1

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  • DOI: https://doi.org/10.1007/978-3-642-70798-8_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-15925-4

  • Online ISBN: 978-3-642-70798-8

  • eBook Packages: Springer Book Archive

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