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The Effect of Age on Rat Liver Drug Metabolism

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Drugs and Aging

Abstract

The elderly use drugs more often than do young persons. In the Netherlands, about 80% of people older than 80 years regularly use drugs, which is high in comparison with the 20% of the 20– to 30–year olds. In addition, the elderly use more drugs simultaneously (Smith 1979). Furthermore, the incidence of adverse drug reactions in the elderly is about 2–3 times higher than in young people (Seidl et al. 1966; Hurwitz et al. 1969; Smidt and McQueen 1972). This high incidence of adverse drug reactions in old age may be due to age-related changes in drug interactions, compliance, pharmacodynamics, and pharmacokinetics. Changes in the pharmacokinetics of drug handling with age might be due to changes in absorption, volume of distribution, metabolism, and excretion. Our attention here will be concentrated on the effect of age on the drug metabolizing capacity of the liver. Many studies on this subject have been performed in rats during the past several years. These studies will be reviewed. Age-related changes in many anatomical, histopathological, biochemical, and physiological factors which may be relevant to changes in the drug metabolizing activity of the rat liver with age will also be considered.

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Author information

Authors and Affiliations

  1. TNO Institute for Experimental Gerontology, P.O. Box 5815, 2280 HV, Rijswijk, The Netherlands

    C. F. A. Van Bezooijen, G. J. M. J. Horbach & C. F. Hollander

Authors
  1. C. F. A. Van Bezooijen
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  2. G. J. M. J. Horbach
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  3. C. F. Hollander
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Editor information

Editors and Affiliations

  1. Universität Erlangen-Nürnberg, Flurstraße 17, D-8500, Nürnberg, Germany

    Dieter Platt (Direktor des Instituts für Gerontologie) (Direktor des Instituts für Gerontologie)

  2. 2. Medizinischen Klinik Klinikum Nürnberg, Flurstraße 17, D-8500, Nürnberg, Germany

    Dieter Platt (Direktor des Instituts für Gerontologie) (Direktor des Instituts für Gerontologie)

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© 1986 Springer-Verlag Berlin Heidelberg

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Van Bezooijen, C.F.A., Horbach, G.J.M.J., Hollander, C.F. (1986). The Effect of Age on Rat Liver Drug Metabolism. In: Platt, D. (eds) Drugs and Aging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70788-9_4

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  • DOI: https://doi.org/10.1007/978-3-642-70788-9_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70790-2

  • Online ISBN: 978-3-642-70788-9

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