Abstract
Studies into the mechanisms of biological aging are, for the most part, motivated by the desire to manipulate the aging process. Intervention into the aging process may be aimed at different but somehow related goals, e.g., prolonging mean and/ or maximum life span, lowering the rate of aging, extending the vigorous years of life, or alleviating the deficiencies of old age. However, the type of study needed for assessing the effect of intervention into the multicellular aging process is in contrast to the usual pharmacological test procedures since the complex process to be measured does not at present allow for the development of simple, well-de-fined models. Obviously, the normal aging2 of the organism does not simply emerge from changes in a particular type of molecule, cell, organ, or functional system, but is probably a systemic process shaped by numerous interactions in a biological hierarchy (Witten 1983). If we use a comparatively simple, well-defined test model, like collagen aging or the clonal aging of mitotieally active cells, we will see the effects of intervention on the molecules or cells but we will not be able to predict what consequences this will have on the aging pattern of the organism as a whole. However, it is this complex pattern of effects that will determine the medical success of intervention.
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© 1986 Springer-Verlag Berlin Heidelberg
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Hofecker, G., Skalicky, M., Niedermüller, H., Kment, A. (1986). Long-Term Effects of Heterologous Fetal Testis Material on the Biological Age of the Male Rat. In: Platt, D. (eds) Drugs and Aging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70788-9_16
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DOI: https://doi.org/10.1007/978-3-642-70788-9_16
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