Abstract
Physiological changes accompanying old age are nowadays well known, especially the reduction in renal function, i.e., in glomerular filtration rate, which is reflected by a decrease of creatinine or inulin clearance. One of the compounds whose pharmacokinetics are correlated with renal function is the relatively cardioselective, hydrophilic β-receptor antagonist atenolol (Fig. 1), which is widely used in the treatment of hypertension. It was shown to be effective in elderly patients; therefore the pharmacokinetic behavior and the corresponding effects of the drug should be known in old age.
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© 1986 Springer-Verlag Berlin Heidelberg
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Spahn, H., Mühlberg, W., Mutschler, E., Platt, D. (1986). Age-Dependent Pharmacokinetics of Atenolol in Patients with Multiple Diseases. In: Platt, D. (eds) Drugs and Aging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70788-9_15
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DOI: https://doi.org/10.1007/978-3-642-70788-9_15
Publisher Name: Springer, Berlin, Heidelberg
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