Pharmacokinetics of Acebutolol in the Elderly

  • W. Möhrke
  • E. Mutschler
  • W. Mühlberg
  • D. Platt
Conference paper

Abstract

β- Blockers are used as first-line drugs in the treatment of hypertension. Acebutolol has also been shown to be effective and safe in an elderly population (Guerin et al. 1981). After absorption acebutolol is metabolized by hydrolysis of the amide group to the amine (metabolite I) and conjugated to diacetolol (metabolite II). A second minor metabolic pathway involves the reduction of the acetyl moiety (metabolite III) (Fig. 1).

Keywords

Hydrolysis HPLC Urea Creatinine Amide 

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • W. Möhrke
    • 1
  • E. Mutschler
    • 2
  • W. Mühlberg
    • 4
  • D. Platt
    • 3
    • 4
  1. 1.Röhm PharmaWeiterstadtGermany
  2. 2.Pharmakologisches Institut für NaturwissenschaftlerJ.W. Goethe-UniversitätFrankfurtGermany
  3. 3.Institut für GerontologieUniversität Erlangen-NürnbergGermany
  4. 4.2. Medizinische KlinikKlinikum NürnbergNürnbergGermany

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