Pharmacokinetics of Acebutolol in the Elderly
β- Blockers are used as first-line drugs in the treatment of hypertension. Acebutolol has also been shown to be effective and safe in an elderly population (Guerin et al. 1981). After absorption acebutolol is metabolized by hydrolysis of the amide group to the amine (metabolite I) and conjugated to diacetolol (metabolite II). A second minor metabolic pathway involves the reduction of the acetyl moiety (metabolite III) (Fig. 1).
KeywordsHydrolysis HPLC Urea Creatinine Amide
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