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Neurotransmitter Alterations in the Aging Brain

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Proof of Therapeutical Effectiveness of Nootropic and Vasoactive Drugs

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Abstract

This review of neurotransmitter alterations in aging brain is intended to focus on studies of human and animal material where one or more measurements were made of these special brain substances. There are several reasons to study neurotransmitter substances in aging nervous system: 1. neurotransmitters provide the means for communication between neurons in the CNS, and therefore, play a key role in the efficient processing of sensory, motor and integrative neural signals, as well as controlling the endocrine systems of the body [68–70]; 2. the loss of a particular neurotransmitter, dopamine, shows a strong correlation with age in man and animals, and is etiological for the age-related disease, Parkinsonism; 3. the means for detecting transmitters are easily adapted for quantitative analysis, allowing age vs transmitter level correlations, and 4. the potential for pharmacological intervention on brain aging is based, in part, on the known structure and metabolism of the neurotransmitters [41, 46].

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    F. E. Bloom

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    Heinz Heidrich

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Rogers, J., Shoemaker, W.J., Bloom, F.E. (1986). Neurotransmitter Alterations in the Aging Brain. In: Heidrich, H. (eds) Proof of Therapeutical Effectiveness of Nootropic and Vasoactive Drugs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70786-5_6

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