A Placebo-Controlled Study with Nicergoline in Patients with Organic Brain Syndrome, Suffering from Cochlear and Vestibular Disturbances

  • N. Martucci
  • V. Manna
  • A. Battaglia


According to Agnoli [1], a clinical classification of aging brain syndromes can be proposed as follows:
  1. 1.

    Physiological aging brain

  2. 2.

    Pathological aging brain, including

  3. (a)

    organic brain syndrome (memory disturbances; extrapyramidal disorders; pseudobulbar syndrome; psychiatric symptoms, mainly depression; somatic symptoms such as dizziness and tinnitus)

  4. (b)

    chronic cerebrovascular disorders

  5. (c)

    multi-infarct dementia

  6. (d)

    Alzheimer-type senile dementia

The organic brain syndrome manifests itself with slight recent memory disturbances and other psychiatric findings. It is also associated with mild extrapyramidal symptoms (extrapyramidal hypertonus and mild resting tremor), with pseudobulbar symptoms (short-step gait, involuntary laughing and crying, dysphagia), with psychiatric symptoms (mild mood depression, anxiety, confusion and sleep disturbances) and subjective symptoms including dizziness, tinnitus, fatigue and headache [2].


Ergot Alkaloid Senile Dementia Hamilton Rating Scale Memory Disturbance Organic Brain Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Agnoli A, Denaro A, Ruggeri S (1982) Definition and therapy of chronic cerebro-vascular diseases. Pathol Biol 30: 312–317PubMedGoogle Scholar
  2. 2.
    Mayer-Gross W, Slater E, Roth M (1963) Psichiatria Clinica, Sansoni Edizioni Scientifiche, FirenzeGoogle Scholar
  3. 3.
    Arrigo A, Moglia A, Borsotti L, Massarini M, Alfonsi E, Battaglia A, Sacchetti G (1982) A double-blind, placebo-controlled, crossover trial with nicergoline in patients with senile de¬mentia. Int J Clin Pharm Res [Suppl 1] 11: 33–41Google Scholar
  4. 4.
    Moglia A, Arrigo A, Battaglia A, Sacchetti G (1984) Psychopharmacology of senile dementia: placebo controlled clinical studies with nicergoline. International Congress on “Function in the Ageing Brain from Physiological Ageing to Dementia”. Saint Germain en Laye, 12-14/ 4 /84Google Scholar
  5. 5.
    Guerrini M, Acciavatti A, Pecchi S, Cappelli R, Sacchetti G, Forconi S, Di Perri T (1981) Haemorheological and haemodynamic effects of single i.v. nicergoline in patients with peripheral vascular disease. A double-blind, cross-over study against placebo. International Symposium Aging Brain and Ergot Alkaloids. Roma, 28–30 October, 1981Google Scholar
  6. 6.
    Goga J A, Hambacher WO (1977) Psychologic and behavioural assessment of geriatric patients: a review. J Am Geriat Soc 25: 232–237PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • N. Martucci
    • 1
  • V. Manna
    • 1
  • A. Battaglia
    • 2
  1. 1.Department of NeurologyUniversity of L’AquilaL’AquilaItaly
  2. 2.Medical Department, Pharmaceutical DivisionFarmitalia Carlo ErbaMilanoItaly

Personalised recommendations